Search Results - "Zimmerman, Jacquelyn"

Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy by Li, Keyu, Tandurella, Joseph A., Gai, Jessica, Zhu, Qingfeng, Lim, Su Jin, Thomas, Dwayne L., Xia, Tao, Mo, Guanglan, Mitchell, Jacob T., Montagne, Janelle, Lyman, Melissa, Danilova, Ludmila V., Zimmerman, Jacquelyn W., Kinny-Köster, Benedict, Zhang, Tengyi, Chen, Linda, Blair, Alex B., Heumann, Thatcher, Parkinson, Rose, Durham, Jennifer N., Narang, Amol K., Anders, Robert A., Wolfgang, Christopher L., Laheru, Daniel A., He, Jin, Osipov, Arsen, Thompson, Elizabeth D., Wang, Hao, Fertig, Elana J., Jaffee, Elizabeth M., Zheng, Lei

“…Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates optimization and maintenance of activated effector T cells (Teff). We…”
Get full text

Solving for Chemotherapeutic Sensitivity: Adapting “Black Box” Methods to Study Patient-Derived Tumor Organoids by Seppälä, Toni T., Zimmerman, Jacquelyn W., Burkhart, Richard A.

Get full text

Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer by Seppälä, Toni T., Zimmerman, Jacquelyn W., Sereni, Elisabetta, Plenker, Dennis, Suri, Reecha, Rozich, Noah, Blair, Alex, Thomas, Dwayne L., Teinor, Jonathan, Javed, Ammar, Patel, Hardik, Cameron, John L., Burns, William R., He, Jin, Tuveson, David A., Jaffee, Elizabeth M., Eshleman, James, Szabolcs, Annamaria, Ryan, David P., Ting, David T., Wolfgang, Christopher L., Burkhart, Richard A.

“…OBJECTIVE:PDAC patients who undergo surgical resection and receive effective chemotherapy have the best chance of long-term survival. Unfortunately, we lack…”
Get full text

Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response by Seppälä, Toni T, Zimmerman, Jacquelyn W, Suri, Reecha, Zlomke, Haley, Ivey, Gabriel D, Szabolcs, Annamaria, Shubert, Christopher R, Cameron, John L, Burns, William R, Lafaro, Kelly J, He, Jin, Wolfgang, Christopher L, Zou, Ying S, Zheng, Lei, Tuveson, David A, Eshlemann, James R, Ryan, David P, Kimmelman, Alec C, Hong, Theodore S, Ting, David T, Jaffee, Elizabeth M, Burkhart, Richard A

“…Patient-derived organoids (PDO) are a promising technology to support precision medicine initiatives for patients with pancreatic ductal adenocarcinoma (PDAC)…”
Get full text

Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion by Jeong, Yea Ji, Knutsdottir, Hildur, Shojaeian, Fatemeh, Lerner, Michael G, Wissler, Maria F, Henriet, Elodie, Ng, Tammy, Datta, Shalini, Navarro-Serer, Bernat, Chianchiano, Peter, Kinny-Köster, Benedict, Zimmerman, Jacquelyn W, Stein-O'Brien, Genevieve, Gaida, Matthias M, Eshleman, James R, Lin, Ming-Tseh, Fertig, Elana J, Ewald, Andrew J, Bader, Joel S, Wood, Laura D

“…Pancreatic ductal adenocarcinoma (PDAC) frequently presents with metastasis, but the molecular programs in human PDAC cells that drive invasion are not well…”
Get full text

Patient-derived Organoid Pharmacotyping As A Predictive Tool for Therapeutic Selection in Pancreatic Ductal Adenocarcinoma by Nicolson, Norman G, Tandurella, Joseph A, Wu, Lawrence W, Patel, Jignasha, Morris, Eli, Seppälä, Toni T, Guinn, Samantha, Zlomke, Haley, Shubert, Christopher R, Lafaro, Kelly J, Burns, William R, Cameron, John L, He, Jin, Fertig, Elana J, Jaffee, Elizabeth M, Zimmerman, Jacquelyn W, Burkhart, Richard A

“…We integrate a new approach to chemosensitivity data for clinically-relevant regimen matching, and demonstrate the relationship with clinical outcomes in a…”
Get full text

Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression by Zabransky, Daniel J, Chhabra, Yash, Fane, Mitchell E, Kartalia, Emma, Leatherman, James M, Hüser, Laura, Zimmerman, Jacquelyn W, Delitto, Daniel, Han, Song, Armstrong, Todd D, Charmsaz, Soren, Guinn, Samantha, Pramod, Sneha, Thompson, Elizabeth D, Hughes, Steven J, O'Connell, Jennifer, Egan, Josephine M, Jaffee, Elizabeth M, Weeraratna, Ashani T

“…Pancreatic cancer is more prevalent in older individuals and often carries a poorer prognosis for them. The relationship between the microenvironment and…”
Get full text

Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma by Wehrli, Marc, Guinn, Samantha, Birocchi, Filippo, Kuo, Adam, Sun, Yi, Larson, Rebecca C, Almazan, Antonio J, Scarfò, Irene, Bouffard, Amanda A, Bailey, Stefanie R, Anekal, Praju Vikas, Montero Llopis, Paula, Nieman, Linda T, Song, Yuhui, Xu, Katherine H, Berger, Trisha R, Kann, Michael C, Leick, Mark B, Silva, Harrison, Salas-Benito, Diego, Kienka, Tamina, Grauwet, Korneel, Armstrong, Todd D, Zhang, Rui, Zhu, Qingfeng, Fu, Juan, Schmidts, Andrea, Korell, Felix, Jan, Max, Choi, Bryan D, Liss, Andrew S, Boland, Genevieve M, Ting, David T, Burkhart, Richard A, Jenkins, Russell W, Zheng, Lei, Jaffee, Elizabeth M, Zimmerman, Jacquelyn W, Maus, Marcela V

“…Targeting solid tumors with chimeric antigen receptor (CAR) T cells remains challenging due to heterogenous target antigen expression, antigen escape, and the…”
Get full text

Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS by Johnson, Jeanette A. I., Tsang, Ashley P., Mitchell, Jacob T., Zhou, David L., Bowden, Julia, Davis-Marcisak, Emily, Sherman, Thomas, Liefeld, Ted, Loth, Melanie, Goff, Loyal A., Zimmerman, Jacquelyn W., Kinny-Köster, Ben, Jaffee, Elizabeth M., Tamayo, Pablo, Mesirov, Jill P., Reich, Michael, Fertig, Elana J., Stein-O’Brien, Genevieve L.

“…Non-negative matrix factorization (NMF) is an unsupervised learning method well suited to high-throughput biology. However, inferring biological processes from…”
Get full text

Molecular mechanisms of Polyphyllin I-induced apoptosis and reversal of the epithelial–mesenchymal transition in human osteosarcoma cells by Chang, Junli, Wang, Hongshen, Wang, Xianyang, Zhao, Yongjian, Zhao, Dongfeng, Wang, Chenglong, Li, Yimian, Yang, Zhilie, Lu, Sheng, Zeng, Qinghua, Zimmerman, Jacquelyn, Shi, Qi, Wang, Yongjun, Yang, Yanping

“…Osteosarcoma is a most common highly malignant bone tumor in children and adolescents. Polyphyllin I (PPI) is an ethanol extraction from Paris polyphylla Smith…”
Get full text

Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma by Guinn, Samantha, Kinny-Köster, Benedict, Tandurella, Joseph A, Mitchell, Jacob T, Sidiropoulos, Dimitrios N, Loth, Melanie, Lyman, Melissa R, Pucsek, Alexandra B, Zabransky, Daniel J, Lee, Jae W, Kartalia, Emma, Ramani, Mili, Seppälä, Toni T, Cherry, Christopher, Suri, Reecha, Zlomke, Haley, Patel, Jignasha, He, Jin, Wolfgang, Christopher L, Yu, Jun, Zheng, Lei, Ryan, David P, Ting, David T, Kimmelman, Alec, Gupta, Anuj, Danilova, Ludmila, Elisseeff, Jennifer H, Wood, Laura D, Stein-O'Brien, Genevieve, Kagohara, Luciane T, Jaffee, Elizabeth M, Burkhart, Richard A, Fertig, Elana J, Zimmerman, Jacquelyn W

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by an immunosuppressive tumor microenvironment enriched with…”
Get full text

Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development by Chu, Nina J, Anders, Robert A, Fertig, Elana J, Cao, Minwei, Hopkins, Alexander C, Keenan, Bridget P, Popovic, Aleksandra, Armstrong, Todd D, Jaffee, Elizabeth M, Zimmerman, Jacquelyn W

“…Almost all pancreatic ductal adenocarcinomas (PDA) develop following KRAS activation, which triggers epithelial transformation and recruitment of desmoplastic…”
Get full text

Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection by Delitto, Daniel, Zabransky, Daniel J., Chen, Fangluo, Thompson, Elizabeth D., Zimmerman, Jacquelyn W., Armstrong, Todd D., Leatherman, James M., Suri, Reecha, Lopez-Vidal, Tamara Y., Huff, Amanda L., Lyman, Melissa R., Guinn, Samantha R., Baretti, Marina, Kagohara, Luciane T., Ho, Won Jin, Azad, Nilofer S., Burns, William R., He, Jin, Wolfgang, Christopher L., Burkhart, Richard A., Zheng, Lei, Yarchoan, Mark, Zaidi, Neeha, Jaffee, Elizabeth M.

“…Tumor involvement of major vascular structures limits surgical options in pancreatic adenocarcinoma (PDAC), which in turn limits opportunities for cure…”
Get full text

Cancer-cell-derived sialylated IgG as a novel biomarker for predicting poor pathological response to neoadjuvant therapy and prognosis in pancreatic cancer by Cui, Ming, Shoucair, Sami, Liao, Quan, Qiu, Xiaoyan, Kinny-Köster, Benedict, Habib, Joseph R, Ghabi, Elie M, Wang, Junke, Shin, Eun Ji, Leng, Sean X, Ali, Syed Z, Thompson, Elizabeth D, Zimmerman, Jacquelyn W, Shubert, Christopher R, Lafaro, Kelly J, Burkhart, Richard A, Burns, William R, Zheng, Lei, He, Jin, Zhao, Yupei, Wolfgang, Christopher L, Yu, Jun

“…Neoadjuvant therapy (NAT) is increasingly applied in pancreatic ductal adenocarcinoma (PDAC); however, accurate prediction of therapeutic response to NAT…”
Get full text

PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration by Bell, Alexander T F, Mitchell, Jacob T, Kiemen, Ashley L, Lyman, Melissa, Fujikura, Kohei, Lee, Jae W, Coyne, Erin, Shin, Sarah M, Nagaraj, Sushma, Deshpande, Atul, Wu, Pei-Hsun, Sidiropoulos, Dimitrios N, Erbe, Rossin, Stern, Jacob, Chan, Rena, Williams, Stephen, Chell, James M, Ciotti, Lauren, Zimmerman, Jacquelyn W, Wirtz, Denis, Ho, Won Jin, Zaidi, Neeha, Thompson, Elizabeth, Jaffee, Elizabeth M, Wood, Laura D, Fertig, Elana J, Kagohara, Luciane T

“…This study introduces a new imaging, spatial transcriptomics (ST), and single-cell RNA-sequencing integration pipeline to characterize neoplastic cell state…”
Get more information

Fibrinogen consumption and use of heparin are risk factors for delayed bleeding during acute promyelocytic leukemia induction by Hambley, Bryan C., Norsworthy, Kelly J., Jasem, Jagar, Zimmerman, Jacquelyn W., Shenderov, Eugene, Webster, Jonathan A., Showel, Margaret M., Gondek, Lukasz P., Dalton, William B., Prince, Gabrielle, Gladstone, Douglas E., Streiff, Michael B., Pratz, Keith W., Gojo, Ivana, Ghiaur, Gabriel, Levis, Mark J., Smith, B. Douglas, DeZern, Amy E.

Get full text

Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx by Jimenez, Hugo, Wang, Minghui, Zimmerman, Jacquelyn W., Pennison, Michael J., Sharma, Sambad, Surratt, Trevor, Xu, Zhi-Xiang, Brezovich, Ivan, Absher, Devin, Myers, Richard M., DeYoung, Barry, Caudell, David L., Chen, Dongquan, Lo, Hui-Wen, Lin, Hui-Kuan, Godwin, Dwayne W., Olivier, Michael, Ghanekar, Anand, Chen, Kui, Miller, Lance D., Gong, Yijian, Capstick, Myles, D'Agostino, Ralph B., Munden, Reginald, Merle, Philippe, Barbault, Alexandre, Blackstock, Arthur W., Bonkovsky, Herbert L., Yang, Guang-Yu, Jin, Guangxu, Liu, Liang, Zhang, Wei, Watabe, Kounosuke, Blackman, Carl F., Pasche, Boris C.

“…Administration of amplitude modulated 27·12 MHz radiofrequency electromagnetic fields (AM RF EMF) by means of a spoon-shaped applicator placed on the patient's…”
Get full text

SMAD4 is a potential prognostic marker in human breast carcinomas by Liu, Nan-nan, Xi, Yue, Callaghan, Michael U., Fribley, Andrew, Moore-Smith, Lakisha, Zimmerman, Jacquelyn W., Pasche, Boris, Zeng, Qinghua, Li, Yu-lin

“…SMAD4 is a downstream mediator of transforming growth factor beta. While its tumor suppressor function has been investigated as a prognostic biomarker in…”
Get full text

Balancing Therapy with Thrombopoietin Receptor Agonists and Splenectomy in Refractory Immune Thrombocytopenic Purpura: A Case of Postsplenectomy Thrombocytosis Requiring Plateletpheresis by Zimmerman, Jacquelyn, Brodsky, R. A., Norsworthy, Kelly J.

“…Immune thrombocytopenic purpura (ITP) causes thrombocytopenia through the autoimmune destruction of platelets. Corticosteroids remain the first line of…”
Get full text

Immune-Related Adverse Events Requiring Hospitalization: Spectrum of Toxicity, Treatment, and Outcomes by Balaji, Aanika, Zhang, Jiajia, Wills, Beatriz, Marrone, Kristen A, Elmariah, Hany, Yarchoan, Mark, Zimmerman, Jacquelyn W, Hajjir, Khalid, Venkatraman, Deepti, Armstrong, Deborah K, Laheru, Daniel A, Mehra, Ranee, Ho, Won Jin, Reuss, Joshua E, Heng, Joseph, Vellanki, Paz, Donehower, Ross C, Holdhoff, Matthias, Naidoo, Jarushka

“…Immune checkpoint inhibitors (ICIs) cause immune-related adverse events (irAEs). The proportion of patients who are hospitalized for irAEs and their spectrum,…”
Get full text