Search Results - "Zimmerman, Erik S."

Structural assembly of cullin-RING ubiquitin ligase complexes by Zimmerman, Erik S, Schulman, Brenda A, Zheng, Ning

“…The cullin-RING ubiquitin ligases (CRLs) are the largest family of multi-subunit E3 ligases in eukaryotes, which ubiquitinate protein substrates in numerous…”
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Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System by Zimmerman, Erik S, Heibeck, Tyler H, Gill, Avinash, Li, Xiaofan, Murray, Christopher J, Madlansacay, Mary Rose, Tran, Cuong, Uter, Nathan T, Yin, Gang, Rivers, Patrick J, Yam, Alice Y, Wang, Willie D, Steiner, Alexander R, Bajad, Sunil U, Penta, Kalyani, Yang, Wenjin, Hallam, Trevor J, Thanos, Christopher D, Sato, Aaron K

“…Antibody–drug conjugates (ADCs) are a targeted chemotherapeutic currently at the cutting edge of oncology medicine. These hybrid molecules consist of a tumor…”
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Structural regulation of cullin-RING ubiquitin ligase complexes by Duda, David M, Scott, Daniel C, Calabrese, Matthew F, Zimmerman, Erik S, Zheng, Ning, Schulman, Brenda A

“…▶ Recent structural studies have revealed numerous ways in which CRL E3 ligase activities are controlled, including: ▶ Mechanisms of multimodal CRL E3 ligase…”
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HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system by DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Monteiro-Filho, Carlos M R, Argañaraz, Enrique R, Planelles, Vicente

“…HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G2…”
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HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT by Andersen, Joshua L, DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Kim, Baek, Jacquot, Guillaume, Benichou, Serge, Planelles, Vicente

“…The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage-signaling protein…”
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Activation of the ATR Pathway by Human Immunodeficiency Virus Type 1 Vpr Involves Its Direct Binding to Chromatin In Vivo by Lai, Maoyi, Zimmerman, Erik S, Planelles, Vicente, Chen, Junjie

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Human Immunodeficiency Virus Type 1 Vpr-Mediated G2 Arrest Requires Rad17 and Hus1 and Induces Nuclear BRCA1 and γ-H2AX Focus Formation by Zimmerman, Erik S., Chen, Junjie, Andersen, Joshua L., Ardon, Orly, DeHart, Jason L., Blackett, Jana, Choudhary, Shailesh K., Camerini, David, Nghiem, Paul, Planelles, Vicente

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Genomic atlas of the human plasma proteome by Sun, Benjamin B., Maranville, Joseph C., Peters, James E., Stacey, David, Staley, James R., Blackshaw, James, Burgess, Stephen, Jiang, Tao, Paige, Ellie, Surendran, Praveen, Oliver-Williams, Clare, Kamat, Mihir A., Prins, Bram P., Wilcox, Sheri K., Zimmerman, Erik S., Chi, An, Bansal, Narinder, Spain, Sarah L., Wood, Angela M., Morrell, Nicholas W., Bradley, John R., Janjic, Nebojsa, Roberts, David J., Ouwehand, Willem H., Todd, John A., Soranzo, Nicole, Suhre, Karsten, Paul, Dirk S., Fox, Caroline S., Plenge, Robert M., Danesh, John, Runz, Heiko, Butterworth, Adam S.

“…Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control…”
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Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress In Vitro and In Vivo by ZIMMERMAN, Erik S, SHERMAN, Michael P, GRANT, Robert M, DE NORONHA, Carlos M. C, WEYRICH, Andrew S, GREENE, Warner C, PLANELLES, Vicente, BLACKETT, Jana L, NEIDLEMAN, Jason A, KREIS, Christophe, MUNDT, Pamela, WILLIAMS, Samuel A, WARMERDAM, Maria, KAHN, James, HECHT, Frederick M

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Induction of G2 Arrest and Binding to Cyclophilin A Are Independent Phenotypes of Human Immunodeficiency Virus Type 1 Vpr by ARDON, Orly, ZIMMERMAN, Erik S, ANDERSEN, Joshua L, DEHART, Jason L, BLACKETT, Jana, PLANELLES, Vicente

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The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration by DEHART, Jason L, ANDERSEN, Joshua L, ZIMMERMAN, Erik S, ARDON, Orly, DONG SUNG AN, BLACKETT, Jana, KIM, Baek, PLANELLES, Vicente

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A General Sequence Processing and Analysis Program for Protein Engineering by Stafford, Ryan L, Zimmerman, Erik S, Hallam, Trevor J, Sato, Aaron K

“…Protein engineering projects often amass numerous raw DNA sequences, but no readily available software combines sequence processing and activity correlation…”
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Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress InVitro and In Vivo by Zimmerman, Erik S., Sherman, Michael P., Blackett, Jana L., Neidleman, Jason A., Kreis, Christophe, Mundt, Pamela, Williams, Samuel A., Warmerdam, Maria, Kahn, James, Hecht, Frederick M., Grant, Robert M., de Noronha, Carlos M. C., Weyrich, Andrew S., Greene, Warner C., Planelles, Vicente

“…ABSTRACT The human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) causes cell cycle arrest in G 2 . Vpr-expressing cells display the hallmarks of…”
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Induction of G 2 Arrest and Binding to Cyclophilin A Are Independent Phenotypes of Human Immunodeficiency Virus Type 1 Vpr by Ardon, Orly, Zimmerman, Erik S., Andersen, Joshua L., DeHart, Jason L., Blackett, Jana, Planelles, Vicente

“…ABSTRACT Cyclophilin A (CypA) is a member of a family of cellular proteins that share a peptidyl prolyl cis-trans isomerase (PPIase) activity. CypA was…”
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Induction of G sub(2) Arrest and Binding to Cyclophilin A Are Independent Phenotypes of Human Immunodeficiency Virus Type 1 Vpr by Ardon, Orly, Zimmerman, Erik S, Andersen, Joshua L, DeHart, Jason L, Blackett, Jana, Planelles, Vicente

“…Cyclophilin A (CypA) is a member of a family of cellular proteins that share a peptidyl prolyl cis-trans isomerase (PPIase) activity. CypA was previously…”
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Human Immunodeficiency Virus Type 1 Vpr-Mediated G sub(2) Arrest Requires Rad17 and Hus1 and Induces Nuclear BRCA1 and gamma -H2AX Focus Formation by Zimmerman, Erik S, Chen, Junjie, Andersen, Joshua L, Ardon, Orly, Dehart, Jason L, Blackett, Jana, Choudhary, Shailesh K, Camerini, David, Nghiem, Paul, Planelles, Vicente

“…Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to…”
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Human Immunodeficiency Virus Type 1 Vpr-Mediated G 2 Arrest Requires Rad17 and Hus1 and Induces Nuclear BRCA1 and γ-H2AX Focus Formation by Zimmerman, Erik S., Chen, Junjie, Andersen, Joshua L., Ardon, Orly, DeHart, Jason L., Blackett, Jana, Choudhary, Shailesh K., Camerini, David, Nghiem, Paul, Planelles, Vicente

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