Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles

The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrati...

Full description

Saved in:

Bibliographic Details
Published in:	Bioorganic & medicinal chemistry Vol. 18; no. 18; pp. 5123 - 5125
Main Authors:	Pürstinger, Gerhard, De Palma, Armando M., Zimmerhofer, Günther, Huber, Simone, Ladurner, Sophie, Neyts, Johan
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 15-09-2008 Elsevier
Subjects:	5-Nitro-2-phenoxybenzonitriles Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Combinatorial Chemistry Techniques Coxsackievirus B3 CVB 3 Enterovirus Enterovirus B, Human - drug effects Enterovirus inhibitors Humans MDL-860 Medical sciences Molecular Structure Nitriles - chemical synthesis Nitriles - chemistry Nitriles - pharmacology Pharmacology. Drug treatments Structure-Activity Relationship 5-Nitro-2-phenoxybenzonitriles Antiviral CVB 3 Enterovirus inhibitors MDL-860 Nitro compound Nitrile Ether Picornaviridae Benzene derivatives Enterovirus In vitro Virus Structure activity relation Chlorine Organic compounds Coxsackievirus B3 Chemical synthesis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-894X 0968-0896 1464-3405 1464-3391
DOI:	10.1016/j.bmcl.2008.07.099