Search Results - "Zimmer, Sara L"

Probabilistic models of biological enzymatic polymerization by Hampton, Marshall, Galey, Miranda, Smoniewski, Clara, Zimmer, Sara L

“…In this study, hierarchies of probabilistic models are evaluated for their ability to characterize the untemplated addition of adenine and uracil to the 3'…”
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Circular mitochondrial-encoded mRNAs are a distinct subpopulation of mitochondrial mRNA in Trypanosoma brucei by Smoniewski, Clara M., Mirzavand Borujeni, Poorya, Petersen, Austin, Hampton, Marshall, Salavati, Reza, Zimmer, Sara L.

“…Since the first identification of circular RNA (circRNA) in viral-like systems, reports of circRNAs and their functions in various organisms, cell types, and…”
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Blastocrithidia nonstop mitochondrial genome and its expression are remarkably insulated from nuclear codon reassignment by Afonin, Dmitry A, Gerasimov, Evgeny S, Škodová-Sveráková, Ingrid, Záhonová, Kristína, Gahura, Ondřej, Albanaz, Amanda T S, Myšková, Eva, Bykova, Anastassia, Paris, Zdeněk, Lukeš, Julius, Opperdoes, Fred R, Horváth, Anton, Zimmer, Sara L, Yurchenko, Vyacheslav

“…The canonical stop codons of the nuclear genome of the trypanosomatid Blastocrithidia nonstop are recoded. Here, we investigated the effect of this recoding on…”
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Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae by Albanaz, Amanda T. S, Carrington, Mark, Frolov, Alexander O, Ganyukova, Anna I, Gerasimov, Evgeny S, Kostygov, Alexei Y, LukeÅ¡, Julius, Malysheva, Marina N, Votýpka, Jan, Zakharova, Alexandra, Záhonová, Kristína, Zimmer, Sara L, Yurchenko, Vyacheslav, Butenko, Anzhelika

“…Abstract Background Protists of the family Trypanosomatidae (phylum Euglenozoa) have gained notoriety as parasites affecting humans, domestic animals, and…”
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Kinetoplast genome of 'Leishmania' spp. is under strong purifying selection by Gerasimov, Evgeny S., Novozhilova, Tatiana S., Zimmer, Sara L., Yurchenko, Vyacheslav

“…Instability is an intriguing characteristic of many protist genomes, and trypanosomatids are not an exception in this respect. Some regions of trypanosomatid…”
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Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex by Hashimi, Hassan, Zimmer, Sara L, Ammerman, Michelle L, Read, Laurie K, Lukeš, Julius

“…Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into…”
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Gene expression to mitochondrial metabolism: Variability among cultured Trypanosoma cruzi strains by Kalem, Murat C, Gerasimov, Evgeny S, Vu, Pamela K, Zimmer, Sara L

“…The insect-transmitted protozoan parasite Trypanosoma cruzi experiences changes in nutrient availability and rate of flux through different metabolic pathways…”
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Antibiotic-Inducible Promoter Regulated by the Cell Envelope Stress-Sensing Two-Component System LiaRS of Bacillus subtilis by MASCHER, Thorsten, ZIMMER, Sara L, SMITH, Terry-Ann, HELMANN, John D

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hosts by Ishemgulova, Aygul, Kraeva, Natalya, Hlaváčová, Jana, Zimmer, Sara L, Butenko, Anzhelika, Podešvová, Lucie, Leštinová, Tereza, Lukeš, Julius, Kostygov, Alexei, Votýpka, Jan, Volf, Petr, Yurchenko, Vyacheslav

“…Leishmania virulence factors responsible for the complicated epidemiology of the various leishmaniases remain mainly unidentified. This study is a…”
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A Global Analysis of Enzyme Compartmentalization to Glycosomes by Durrani, Hina, Hampton, Marshall, Rumbley, Jon N, Zimmer, Sara L

“…In kinetoplastids, the first seven steps of glycolysis are compartmentalized into a glycosome along with parts of other metabolic pathways. This organelle…”
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Mitochondrial RNA editing in Trypanoplasma borreli: New tools, new revelations by Gerasimov, Evgeny S., Afonin, Dmitry A., Korzhavina, Oksana A., Lukeš, Julius, Low, Ross, Hall, Neil, Tyler, Kevin, Yurchenko, Vyacheslav, Zimmer, Sara L.

“…[Display omitted] The kinetoplastids are unicellular flagellates that derive their name from the ‘kinetoplast’, a region within their single mitochondrion…”
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The Remarkable Metabolism of Vickermania ingenoplastis : Genomic Predictions by Opperdoes, Fred R, Butenko, Anzhelika, Zakharova, Alexandra, Gerasimov, Evgeny S, Zimmer, Sara L, Lukeš, Julius, Yurchenko, Vyacheslav

“…A recently redescribed two-flagellar trypanosomatid is insensitive to the classical inhibitors of respiration and thrives under anaerobic conditions. Using…”
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Revisiting Trypanosome Mitochondrial Genome Mysteries: Broader and Deeper by Zimmer, Sara L.

“…What do the products of a genome do, and when and why are they needed? For the protein products of the trypanosomatid parasites’ mitochondrial genomes, the…”
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Additive and transcript-specific effects of KPAP1 and TbRND activities on 3' non-encoded tail characteristics and mRNA stability in Trypanosoma brucei by Zimmer, Sara L, McEvoy, Sarah M, Menon, Sarita, Read, Laurie K

“…Short, non-encoded oligo(A), oligo(U), or A/U tails can impact mRNA stability in kinetoplastid mitochondria. However, a comprehensive picture of the relative…”
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Mitochondrial Gene Expression Is Responsive to Starvation Stress and Developmental Transition in Trypanosoma cruzi by Shaw, Aubie K, Kalem, Murat C, Zimmer, Sara L

“…Trypanosoma cruzi parasites causing Chagas disease are passed between mammals by the triatomine bug vector. Within the insect, T. cruzi epimastigote-stage…”
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Role of PIP39 in oxidative stress response appears conserved in kinetoplastids by Durrani, Hina, Bjork, James A., Zimmer, Sara L.

“…Kinetoplastids, a group of flagellated protists that are often insect intestinal parasites, encounter various sources of oxidative stress. Such stressors…”
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Genome-Based Analysis of Chlamydomonas reinhardtii Exoribonucleases and Poly(A) Polymerases Predicts Unexpected Organellar and Exosomal Features by Zimmer, Sara L, Fei, Zhangjun, Stern, David B

“…Enzymes from several gene families modify RNA molecules at their extremities. These reactions occur in several cellular compartments and affect every class of…”
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Marked for Translation: Long A/U Tails as an Interface between Completion of RNA Editing and Ribosome Recruitment by Read, Laurie K., Zimmer, Sara L., Ammerman, Michelle L.

“…The mechanism by which ribosomes select translatable mRNAs from the complex mixture of incompletely edited mRNAs in trypanosome mitochondria has remained a…”
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Trypanosoma cruzi strain and starvation-driven mitochondrial RNA editing and transcriptome variability by Gerasimov, Evgeny S, Ramirez-Barrios, Roger, Yurchenko, Vyacheslav, Zimmer, Sara L

“…is a unicellular protistan parasitic species that is comprised of strains and isolates exhibiting high levels of genetic and metabolic variability. In the…”
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Complete minicircle genome of Leptomonas pyrrhocoris reveals sources of its non-canonical mitochondrial RNA editing events by Gerasimov, Evgeny S, Gasparyan, Anna A, Afonin, Dmitry A, Zimmer, Sara L, Kraeva, Natalya, Lukeš, Julius, Yurchenko, Vyacheslav, Kolesnikov, Alexander

“…Abstract Uridine insertion/deletion (U-indel) editing of mitochondrial mRNA, unique to the protistan class Kinetoplastea, generates canonical as well as…”
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