Search Results - "Zimmer, Luc"

Contribution of Clinical Neuroimaging to the Understanding of the Pharmacology of Methylphenidate by Zimmer, Luc

“…Methylphenidate (MPH) is currently the most widely used molecule in the pharmacologic treatment of attention-deficit hyperactivity disorder (ADHD). Although…”
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Electrophilic Trifluoromethylthiolation of Carbonyl Compounds by Alazet, Sébastien, Zimmer, Luc, Billard, Thierry

“…A general method for the α‐trifluoromethylthiolation of carbonyl compounds, without prefunctionalization, has been developed. Aldehydes, ketones, esters,…”
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Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes by Alazet, Sébastien, Zimmer, Luc, Billard, Thierry

“…Pin the tail on the alkyne: CF3S‐ or CF3CF2S‐alkynes can be simply and quickly obtained by mixing terminal alkynes with a trifluoromethanesulfenamide reagent…”
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Editorial: In vivo functional neuroimaging for pharmacology by Vidal, Benjamin, Zimmer, Luc

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Is There a Role for GPCR Agonist Radiotracers in PET Neuroimaging? by Colom, Matthieu, Vidal, Benjamin, Zimmer, Luc

“…Positron emission tomography (PET) is a molecular imaging modality that enables in vivo exploration of metabolic processes and especially the pharmacology of…”
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Towards in vivo imaging of functionally active 5-HT1A receptors in schizophrenia: concepts and challenges by Razakarivony, Oriane, Newman-Tancredi, Adrian, Zimmer, Luc

“…The serotonin 5-HT 1A receptor has attracted wide attention as a target for treatment of psychiatric disorders. Although this receptor is important in the…”
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Anti-CD20 therapies in multiple sclerosis: From pathology to the clinic by de Sèze, Jérôme, Maillart, Elisabeth, Gueguen, Antoine, Laplaud, David A, Michel, Laure, Thouvenot, Eric, Zephir, Hélène, Zimmer, Luc, Biotti, Damien, Liblau, Roland

“…The immune system plays a significant role in multiple sclerosis. While MS was historically thought to be T cell-mediated, multiple pieces of evidence now…”
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Oxytocin and Serotonin Brain Mechanisms in the Nonhuman Primate by Lefevre, Arthur, Richard, Nathalie, Jazayeri, Mina, Beuriat, Pierre-Aurélien, Fieux, Sylvain, Zimmer, Luc, Duhamel, Jean-René, Sirigu, Angela

“…Oxytocin (OT) is increasingly studied for its therapeutic potential in psychiatric disorders, which are associated with the deregulation of several…”
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Single subanesthetic dose of ketamine produces delayed impact on brain [ 18 F]FDG PET imaging and metabolic connectivity in rats by Chaib, Sarah, Bouillot, Caroline, Bouvard, Sandrine, Vidal, Benjamin, Zimmer, Luc, Levigoureux, Elise

“…Ketamine, a glutamate NMDA receptor antagonist, is suggested to act very rapidly and durably on the depressive symptoms including treatment-resistant patients…”
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Identification of factors associated with hospitalization in an outpatient population with mental health conditions: a case-control study by Lebrat, Matthieu, Megard, Rachel, Dananché, Cédric, Zimmer, Luc, Plasse, Julien, Franck, Nicolas

“…Addressing relevant determinants for preserved person-centered rehabilitation in mental health is still a major challenge. Little research focuses on factors…”
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[18F]MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain by Aznavour, Nicolas, Zimmer, Luc

“…Serotonin (5-hydroxytryptamine, 5-HT) and its various receptors are involved in numerous CNS functions and psychiatric disorders. 5-HT(1A), the…”
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NMDA antagonist agents for the treatment of symptoms in autism spectrum disorder: a systematic review and meta-analysis by Dessus-Gilbert, Marie-Lou, Nourredine, Mikail, Zimmer, Luc, Rolland, Benjamin, Geoffray, Marie-Maude, Auffret, Marine, Jurek, Lucie

“…This systematic review and meta-analysis aimed to assess the efficacy of NMDA antagonists in ASD (Autism Spectrum Disorder) on the core (communication and…”
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Impaired Local and Long-Range Brain Connectivity and Visual Response in a Genetic Rat Model of Hyperactivity Revealed by Functional Ultrasound by Droguerre, Marine, Vidal, Benjamin, Valdebenito, Marco, Mouthon, Franck, Zimmer, Luc, Charvériat, Mathieu

“…Attention-Deficit hyperactivity disorder (ADHD) is a central nervous system (CNS) disorder frequently associated with other psychiatric disorders…”
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A multi-atlas based method for automated anatomical rat brain MRI segmentation and extraction of PET activity by Lancelot, Sophie, Roche, Roxane, Slimen, Afifa, Bouillot, Caroline, Levigoureux, Elise, Langlois, Jean-Baptiste, Zimmer, Luc, Costes, Nicolas

“…Preclinical in vivo imaging requires precise and reproducible delineation of brain structures. Manual segmentation is time consuming and operator dependent…”
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3D-printed dual holder system for simultaneous rat PET scanning: design and influence on quantification by Bouillot, Caroline, Daligault, Sébastien, Bolbos, Radu, Costes, Nicolas, Zimmer, Luc

“…Background The low throughout of small animal positron emission tomography (PET) images acquisitions represents a substantial limitation. The aims of this…”
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Pharmaco-fUS for Characterizing Drugs for Alzheimer’s Disease – The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine by Vidal, Benjamin, Droguerre, Marine, Valdebenito, Marco, Zimmer, Luc, Hamon, Michel, Mouthon, Franck, Charvériat, Mathieu

“…Donepezil (DPZ) is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer’s disease (AD). Beyond the…”
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Multimodal imaging study of the 5-HT1A receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia by Chaib, Sarah, Vidal, Benjamin, Bouillot, Caroline, Depoortere, Ronan, Newman-Tancredi, Adrian, Zimmer, Luc, Levigoureux, Elise

“…[Display omitted] •Hemiparkinsonian (HPK) rats show a specific L-DOPA-induced brain metabolic pattern.•NLX-112 attenuated or reversed the cerebral effects of…”
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[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations by Colom, Matthieu, Vidal, Benjamin, Fieux, Sylvain, Redoute, Jérôme, Costes, Nicolas, Lavenne, Franck, Mérida, Inés, Irace, Zacharie, Iecker, Thibaud, Bouillot, Caroline, Billard, Thierry, Newman-Tancredi, Adrian, Zimmer, Luc

“…Introduction Serotonin is involved in a variety of physiological functions and brain disorders. In this context, efforts have been made to investigate the in…”
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Bayesian Estimation of the ntPET Model in Single-Scan Competition PET Studies by Irace, Zacharie, Mérida, Inés, Redouté, Jérôme, Fonteneau, Clara, Suaud-Chagny, Marie-Françoise, Brunelin, Jérôme, Vidal, Benjamin, Zimmer, Luc, Reilhac, Anthonin, Costes, Nicolas

“…This paper proposes an innovative method, named b-ntPET, for solving a competition model in PET. The model is built upon the state-of-the-art method called…”
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Enhanced anxiety observed in cocaine withdrawn rats is associated with altered reactivity of the dorsomedial prefrontal cortex by El Hage, Cynthia, Rappeneau, Virginie, Etievant, Adeline, Morel, Anne-Laure, Scarna, Hélène, Zimmer, Luc, Bérod, Anne

“…Discontinuation of drug intake in cocaine abusers commonly produces a variety of adverse withdrawal symptoms among which anxiety and depression-related…”
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