Search Results - "Zimmer, E."

Fluorine Conformational Effects in Organocatalysis: An Emerging Strategy for Molecular Design by Zimmer, Lucie E., Sparr, Christof, Gilmour, Ryan

“…Molecular design strategies that profit from the intrinsic stereoelectronic and electrostatic effects of fluorinated organic molecules have mainly been…”
Get full text

Consequences of Metabolic Disruption in Alzheimer’s Disease Pathology by Ryu, J. C., Zimmer, E. R., Rosa-Neto, P., Yoon, S. O.

“…Alzheimer’s disease (AD) is an irreversible, progressive disease that slowly destroys cognitive function, such as thinking, remembering, and reasoning, to a…”
Get full text

Alzheimer's disease master regulators analysis: search for potential molecular targets and drug repositioning candidates by Vargas, D M, De Bastiani, M A, Zimmer, E R, Klamt, F

“…Alzheimer's disease (AD) is a multifactorial and complex neuropathology that involves impairment of many intricate molecular mechanisms. Despite recent…”
Get full text

Differential Pathomechanisms of Desmoglein 1 Transmembrane Domain Mutations in Skin Disease by Zimmer, Stephanie E., Takeichi, Takuya, Conway, Daniel E., Kubo, Akiharu, Suga, Yasushi, Akiyama, Masashi, Kowalczyk, Andrew P.

“…Dominant and recessive mutations in the desmosomal cadherin, desmoglein (DSG) 1, cause the skin diseases palmoplantar keratoderma (PPK) and severe dermatitis,…”
Get full text

Pancreatic mesenchyme regulates epithelial organogenesis throughout development by Landsman, Limor, Nijagal, Amar, Whitchurch, Theresa J, Vanderlaan, Renee L, Zimmer, Warren E, Mackenzie, Tippi C, Hebrok, Matthias

“…The developing pancreatic epithelium gives rise to all endocrine and exocrine cells of the mature organ. During organogenesis, the epithelial cells receive…”
Get full text

Fluorinated Organocatalysts for the Enantioselective Epoxidation of Enals: Molecular Preorganisation by the Fluorine-Iminium Ion Gauche Effect by Tanzer, Eva-Maria, Zimmer, Lucie E., Schweizer, W. Bernd, Gilmour, Ryan

“…The fluorine‐iminium ion gauche effect is triggered upon union of a secondary β‐fluoroamine and an α,β‐unsaturated aldehyde, providing a useful strategy for…”
Get full text

Perfluorinated compounds differentially affect steroidogenesis and viability in the human adrenocortical carcinoma (H295R) in vitro cell assay by Kraugerud, Marianne, Zimmer, Karin E., Ropstad, Erik, Verhaegen, Steven

“…► We investigate steroid secretion, gene expression and cell cycle alterations in H295R cells exposed to PFOS, PFOA and PFNA. ► High dose of PFOS alters…”
Get full text

Maternal environmental enrichment protects neonatal brains from hypoxic-ischemic challenge by mitigating brain energetic dysfunction and modulating glial cell responses by Durán-Carabali, L.E., Odorcyk, F.K., Grun, L.K., Schmitz, F., Ramires Junior, O.V., de Oliveria, M.R., Campos, K.F., Hoeper, E., Carvalho, A.V.S, Greggio, S., Venturine, G.T., Zimmer, E.R, Barbé-Tuana, F., Wyse, A.T.S, Netto, C.A.

“…There is evidence that maternal milieu and changes in environmental factors during the prenatal period may exert a lasting impact on the brain health of the…”
Get full text

Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function by Hammerle, Constanze M, Sandovici, Ionel, Brierley, Gemma V, Smith, Nicola M, Zimmer, Warren E, Zvetkova, Ilona, Prosser, Haydn M, Sekita, Yoichi, Lam, Brian Y H, Ma, Marcella, Cooper, Wendy N, Vidal-Puig, Antonio, Ozanne, Susan E, Medina-Gómez, Gema, Constância, Miguel

“…The genetic mechanisms that determine the size of the adult pancreas are poorly understood. Imprinted genes, which are expressed in a parent-of-origin-specific…”
Get full text

Differential glucose and beta-hydroxybutyrate metabolism confers an intrinsic neuroprotection to the immature brain in a rat model of neonatal hypoxia ischemia by Odorcyk, F.K., Duran-Carabali, L.E., Rocha, D.S., Sanches, E.F., Martini, A.P., Venturin, G.T., Greggio, S., da Costa, J.C., Kucharski, L.C., Zimmer, E.R., Netto, C.A.

“…Neonatal hypoxia ischemia (HI) is the main cause of newborn mortality and morbidity. Preclinical studies have shown that the immature rat brain is more…”
Get full text

Retinal Thickness Analysis by Race, Gender, and Age Using Stratus OCT by Kashani, Amir H, Zimmer-Galler, Ingrid E, Shah, Syed Mahmood, Dustin, Laurie, Do, Diana V, Eliott, Dean, Haller, Julia A, Nguyen, Quan Dong

“…Purpose To detect differences in retinal thickness among patients of different race, gender, and age using Stratus OCT. Design Cross-sectional study. Methods…”
Get full text

In vivo intervertebral disc mechanical deformation following a treadmill walking “stress test” is inversely related to T1rho relaxation time by Coppock, J.A., Zimmer, N.E., Englander, Z.A., Danyluk, S.T., Kosinski, A.S., Spritzer, C.E., Goode, A.P., DeFrate, L.E.

“…To assess the in vivo relationship between the mechanical response of intervertebral discs (IVDs) to dynamic activity and IVD biochemical composition assessed…”
Get full text

Maternal exposure to a mixture of persistent organic pollutants (POPs) affects testis histology, epididymal sperm count and induces sperm DNA fragmentation in mice by Khezri, Abdolrahman, Lindeman, Birgitte, Krogenæs, Anette K., Berntsen, Hanne F., Zimmer, Karin E., Ropstad, Erik

“…Persistent organic pollutants (POPs) are widespread throughout the environment and some are suspected to induce reproductive toxicity. As animals and humans…”
Get full text

Preparing General Education Teachers for Inclusive Settings: Integrating High-Leverage Practices and Mixed-Reality Simulation in Pre-Service Coursework by Driver, Melissa K, Zimmer, Kate E, Khan, Osman, Sadler, Jasmine V, Draper, Emily

“…Students with disabilities are increasingly being educated in general education classrooms. This exploratory study investigates the efficacy of using…”
Get full text

Preparation of a Storable Zinc Carbenoid Species and Its Application in Cyclopropanation, Chain Extension, and [2,3]-Sigmatropic Rearrangement Reactions by Voituriez, Arnaud, Zimmer, Lucie E, Charette, André B

“…The formation of a new phosphate carbenoid (n-BuO)2P(O)OZnCH2I and its application in organozinc-mediated reactions is described. This carbenoid undergoes very…”
Get full text

Enantioselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes Using gem-Dizinc Reagents by Zimmer, Lucie E, Charette, André B

“…The first asymmetric cyclopropanation of allylic alcohols using gem-dizinc carbenoids, which allows the synthesis of 1,2,3-substituted cyclopropane derivatives…”
Get full text

Prediction of long-term variation in offspring metabolism due to BPA in eggs in rainbow trout using the DEB model by Sadoul, B., Augustine, S., Zimmer, E., Bégout, M.-L., Vijayan, M.M.

“…Bisphenol A (BPA) in eggs prior to fertilization was found to induce long-term metabolic disturbances in juvenile rainbow trout (Oncorhynchus mykiss). Here we…”
Get full text

Serial serum creatinine, SDMA and urinary acute kidney injury biomarker measurements in dogs envenomated by the European adder (Vipera berus) by Harjen, Hannah J, Nicolaysen, Tove V, Negard, Tale, Lund, Hege, Sævik, Bente K, Anfinsen, Kristin P, Moldal, Elena R, Zimmer, Karin E, Rørtveit, Runa

“…Acute kidney injury (AKI) is associated with high morbidity and mortality in dogs, but diagnosis may be impaired due the insensitivity of routine renal…”
Get full text

Molecular Design Exploiting a Fluorine gauche Effect as a Stereoelectronic Trigger by Rey, Yannick P., Zimmer, Lucie E., Sparr, Christof, Tanzer, Eva-Maria, Schweizer, W. Bernd, Senn, Hans Martin, Lakhdar, Sami, Gilmour, Ryan

“…Acyclic conformational control often relies on destabilising noncovalent interactions to give rise to predictable conformer populations. Pertinent examples of…”
Get full text

Seeking to Become All Things: The Neoplatonic Soul and the Next World in Sir Thomas Browne's The Garden of Cyrus by Zimmer, Mary E

“…The relationship of Thomas Browne's The Garden to the ‘[w]orld […] after death’ has been explained in terms of generation and verdancy as symbolic of eternal…”
Get full text