Search Results - "Zimmer, Derek"

Amylin modulates the mesolimbic dopamine system to control energy balance by Mietlicki-Baase, Elizabeth G, Reiner, David J, Cone, Jackson J, Olivos, Diana R, McGrath, Lauren E, Zimmer, Derek J, Roitman, Mitchell F, Hayes, Matthew R

“…Amylin acts in the CNS to reduce feeding and body weight. Recently, the ventral tegmental area (VTA), a mesolimbic nucleus important for food intake and…”
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Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance by Reiner, David J, Mietlicki-Baase, Elizabeth G, McGrath, Lauren E, Zimmer, Derek J, Bence, Kendra K, Sousa, Gregory L, Konanur, Vaibhav R, Krawczyk, Joanna, Burk, David H, Kanoski, Scott E, Hermann, Gerlinda E, Rogers, Richard C, Hayes, Matthew R

“…Astrocytes are well established modulators of extracellular glutamate, but their direct influence on energy balance-relevant behaviors is largely understudied…”
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Glucagon-Like Peptide-1 Receptor Activation in the Ventral Tegmental Area Decreases the Reinforcing Efficacy of Cocaine by Schmidt, Heath D, Mietlicki-Baase, Elizabeth G, Ige, Kelsey Y, Maurer, John J, Reiner, David J, Zimmer, Derek J, Van Nest, Duncan S, Guercio, Leonardo A, Wimmer, Mathieu E, Olivos, Diana R, De Jonghe, Bart C, Hayes, Matthew R

“…Cocaine addiction continues to be a significant public health problem for which there are currently no effective FDA-approved treatments. Thus, there is a…”
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Endogenous Glucagon-like Peptide-1 Receptor Signaling in the Nucleus Tractus Solitarius is Required for Food Intake Control by Alhadeff, Amber L, Mergler, Blake D, Zimmer, Derek J, Turner, Christopher A, Reiner, David J, Schmidt, Heath D, Grill, Harvey J, Hayes, Matthew R

“…Alhough the glucagon-like peptide-1 (GLP-1) system is critical to energy balance control and is a target for obesity pharmacotherapies, the…”
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Amylin Acts in the Lateral Dorsal Tegmental Nucleus to Regulate Energy Balance Through Gamma-Aminobutyric Acid Signaling by Reiner, David J, Mietlicki-Baase, Elizabeth G, Olivos, Diana R, McGrath, Lauren E, Zimmer, Derek J, Koch-Laskowski, Kieran, Krawczyk, Joanna, Turner, Christopher A, Noble, Emily E, Hahn, Joel D, Schmidt, Heath D, Kanoski, Scott E, Hayes, Matthew R

“…Abstract Background The pancreatic- and brain-derived hormone amylin promotes negative energy balance and is receiving increasing attention as a promising…”
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Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress by DELIBEGOVIC, Mirela, ZIMMER, Derek, KAUFFMAN, Caitlin, RAK, Kimberly, HONG, Eun-Gyoung, CHO, You-Ree, KIM, Jason K, KAHN, Barbara B, NEEL, Benjamin G, BENCE, Kendra K

“…Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress Mirela…”
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Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice by Tsou, Ryan C, Zimmer, Derek J, De Jonghe, Bart C, Bence, Kendra K

“…Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed tyrosine phosphatase implicated in the negative regulation of leptin and insulin receptor…”
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Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation by Hayes, Matthew R., Leichner, Theresa M., Zhao, Shiru, Lee, Grace S., Chowansky, Amy, Zimmer, Derek, De Jonghe, Bart C., Kanoski, Scott E., Grill, Harvey J., Bence, Kendra K.

“…Glucagon-like peptide-1 receptor (GLP-1R) activation within the nucleus tractus solitarius (NTS) suppresses food intake and body weight (BW), but the…”
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Amylin Receptor Signaling in the Ventral Tegmental Area is Physiologically Relevant for the Control of Food Intake by MIETLICKI-BAASE, Elizabeth G, RUPPRECHT, Laura E, OLIVOS, Diana R, ZIMMER, Derek J, ALTER, Mark D, PIERCE, R. Christopher, SCHMIDT, Heath D, HAYES, Matthew R

“…The ability of amylin, a pancreatic β-cell-derived neuropeptide, to promote negative energy balance has been ascribed to neural activation at the area…”
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Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress by Agouni, Abdelali, Mody, Nimesh, Owen, Carl, Czopek, Alicja, Zimmer, Derek, Bentires-Alj, Mohamed, Bence, Kendra K, Delibegović, Mirela

“…Obesity is associated with induction of the ER (endoplasmic reticulum)-stress response signalling and insulin resistance. PTP1B (protein tyrosine phosphatase…”
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Binge‐type eating disrupts dopaminergic and GABAergic signaling in the prefrontal cortex and ventral tegmental area by Corwin, Rebecca L.W., Wojnicki, Francis H.E., Zimmer, Derek J., Babbs, R. Keith, McGrath, Lauren E., Olivos, Diana R., Mietlicki‐Baase, Elizabeth G., Hayes, Matthew R.

“…Objective Binge eating is characterized by repeated intermittent bouts of compulsive overconsumption of food. Treatment is challenging given limited…”
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Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of membrane-bound Akt by Rupprecht, Laura E, Mietlicki-Baase, Elizabeth G, Zimmer, Derek J, McGrath, Lauren E, Olivos, Diana R, Hayes, Matthew R

“…Glucagon-like peptide-1 (GLP-1) receptors (GLP-1R) expressed in the nucleus tractus solitarius (NTS) are physiologically required for the control of feeding…”
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Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning by Fuentes, Federico, Zimmer, Derek, Atienza, Marybless, Schottenfeld, Jamie, Penkala, Ian, Bale, Tracy, Bence, Kendra K, Arregui, Carlos O

“…ER-bound PTP1B is expressed in hippocampal neurons, and accumulates among neurite contacts. PTP1B dephosphorylates ß-catenin in N-cadherin complexes ensuring…”
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Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor by Tsou, Ryan C, Rak, Kimberly S, Zimmer, Derek J, Bence, Kendra K

“…Abstract Protein tyrosine phosphatase 1B (PTP1B) is a known regulator of central metabolic signaling, and mice with whole brain-, leptin receptor (LepRb)…”
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Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency by De Jonghe, Bart C, Hayes, Matthew R, Zimmer, Derek J, Kanoski, Scott E, Grill, Harvey J, Bence, Kendra K

“…Leptin regulates energy balance through central circuits that control food intake and energy expenditure, including proopiomelanocortin (POMC) neurons. POMC…”
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Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance by Ozek, Ceren, Zimmer, Derek J, De Jonghe, Bart C, Kalb, Robert G, Bence, Kendra K

“…Abstract Objective Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), play a paramount role in the central…”
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Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation by Hayes, Matthew R., Leichner, Theresa M., Zhao, Shiru, Lee, Grace S., Chowansky, Amy, Zimmer, Derek, De Jonghe, Bart C., Kanoski, Scott E., Grill, Harvey J., Bence, Kendra K.

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Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure by De Jonghe, Bart C, Hayes, Matthew R, Banno, Ryoichi, Skibicka, Karolina P, Zimmer, Derek J, Bowen, Kerisha A, Leichner, Theresa M, Alhadeff, Amber L, Kanoski, Scott E, Cyr, Nicole E, Nillni, Eduardo A, Grill, Harvey J, Bence, Kendra K

“…The adipose tissue-derived hormone leptin regulates energy balance through catabolic effects on central circuits, including proopiomelanocortin (POMC) neurons…”
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Amylin acts in the lateral dorsal tegmental nucleus to regulate energy balance through GABA signaling by Reiner, David J., Mietlicki-Baase, Elizabeth G., Olivos, Diana R., McGrath, Lauren E., Zimmer, Derek J., Koch-Laskowski, Kieran, Krawczyk, Joanna, Turner, Christopher, Noble, Emily E., Hahn, Joel D., Schmidt, Heath D., Kanoski, Scott E., Hayes, Matthew R.

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PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice by Banno, Ryoichi, Zimmer, Derek, De Jonghe, Bart C, Atienza, Marybless, Rak, Kimberly, Yang, Wentian, Bence, Kendra K

“…Protein tyrosine phosphatase 1B (PTP1B) and SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) have been shown in mice to regulate metabolism via the…”
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