Search Results - "Zimbres, Flávia M."

Molecular Modeling Applied to Nucleic Acid-Based Molecule Development by Krüger, Arne, Zimbres, Flávia M, Kronenberger, Thales, Wrenger, Carsten

“…Molecular modeling by means of docking and molecular dynamics (MD) has become an integral part of early drug discovery projects, enabling the screening and…”
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Aptamers: Novel Molecules as Diagnostic Markers in Bacterial and Viral Infections? by Wrenger, Carsten, Ulrich, Henning, Tárnok, Attila, Zimbres, Flávia M.

“…Worldwide the entire human population is at risk of infectious diseases of which a high degree is caused by pathogenic protozoans, worms, bacteria, and virus…”
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Aptamer-Based Imaging of Polyisoprenoids in the Malaria Parasite by Zimbres, Flavia M, Merino, Emilio F, Butschek, Grant J, Butler, Joshua H, Ducongé, Frédéric, Cassera, Maria B

“…Dolichols are isoprenoid end-products of the mevalonate and 2 -methyl-D-erythritol-4-phosphate pathways. The synthesis of dolichols is initiated with the…”
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Cephalotane‐Type Norditerpenoids from Cephalotaxus fortunei var. alpina by Ge, Zhan‐Peng, Zhou, Bin, Zimbres, Flavia M., Cassera, Maria B., Zhao, Jin‐Xin, Yue, Jian‐Min

“…Comprehensive Summary A chemical investigation of the 95% EtOH extract of the seeds of Cephalotaxus fortunei var. alpina led to the isolation of nine new…”
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Oxidative Stress Control by Apicomplexan Parasites by Wrenger, Carsten, Liebau, Eva, Izui, Natália M., Stegehake, Dirk, Zimbres, Flávia M., Meissner, Kamila Anna, Kronenberger, Thales, Bosch, Soraya S., Schettert, Isolmar

“…Apicomplexan parasites cause infectious diseases that are either a severe public health problem or an economic burden. In this paper we will shed light on how…”
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Two Terpenoid Derivatives with Different 3/5/6/6/5‐Fused Pentacyclic Skeletons from Hedyosmum orientale by Fan, Yao‐Yue, Zheng, Cheng‐Yu, Zhou, Bin, Zimbres, Flavia M., Cassera, Maria B., Yue, Jian‐Min

“…Comprehensive Summary Chemical investigation of Hedyosmum orientale led to the identification of two terpenoid derivatives, dyosmunoids A and B (1 and 2)…”
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Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum : A Druggable Target? by Wrenger, Carsten, Sauer, Frank M., Coronado, Monika A., Schettert, Isolmar, Zimbres, Flávia M., Meissner, Kamila Anna, Kronenberger, Thales, Lindner, Jasmin

“…Malaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the…”
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In vitro activity of extracts and isolated polyphenols from West African medicinal plants against Plasmodium falciparum by Ndjonka, Dieudonné, Bergmann, Bärbel, Agyare, Christian, Zimbres, Flávia M., Lüersen, Kai, Hensel, Andreas, Wrenger, Carsten, Liebau, Eva

“…The aim of the study was to screen 11 selected traditional medicinal plants from West Africa for their in vitro antiplasmodial activity in order to determine…”
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Picomolar antimalarial agent from a Chinese medicinal plant by Zhou, Bin, Zimbres, Flavia M., Butler, Joshua H., Xu, Cheng-Hui, Haney, Reagan S., Wu, Yan, Cassera, Maria B., Yue, Jian-Min

“…In our long-term efforts searching for antimalarial agents from Chinese medicinal plants, seven novel dimeric sesquiterpenoids ( 1 – 7 ) with significant…”
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Limonoids from Cipadessa baccifera by Yu, Jin-Hai, Zhang, Hua, Zhou, Bin, Zimbres, Flavia M, Dalal, Seema, Liu, Qun-Fang, Cassera, Maria B, Yue, Jian-Min

“…Eighteen new limonoids, including eight methyl angolensates (1–8) and 10 cipadesins (9–18), were isolated from the leaves of Cipadessa baccifera. Their…”
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Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum by Zimbres, Flavia M., Valenciano, Ana Lisa, Merino, Emilio F., Florentin, Anat, Holderman, Nicole R., He, Guijuan, Gawarecka, Katarzyna, Skorupinska-Tudek, Karolina, Fernández-Murga, Maria L., Swiezewska, Ewa, Wang, Xiaofeng, Muralidharan, Vasant, Cassera, Maria Belen

“…The cis -polyisoprenoid lipids namely polyprenols, dolichols and their derivatives are linear polymers of several isoprene units. In eukaryotes, polyprenols…”
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Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach by Alpizar-Sosa, Edubiel A., Zimbres, Flavia M., Mantilla, Brian S., Dickie, Emily A., Wei, Wenbin, Burle-Caldas, Gabriela A., Filipe, Laura N. S., Van Bocxlaer, Katrien, Price, Helen P., Ibarra-Meneses, Ana V., Beaudry, Francis, Fernandez-Prada, Christopher, Whitfield, Philip D., Barrett, Michael P., Denny, Paul W.

“…The lack of effective vaccines and the development of resistance to the current treatments highlight the urgent need for new anti-leishmanials. Sphingolipid…”
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Structurally intriguing rearranged bicyclogermacrene-type sesquiterpenoid from Aphania oligophylla by Zhou, Bin, Wu, Yan, Zimbres, Flavia M., Cassera, Maria B., Yue, Jian-Min

“…Aphanoid A featuring an unprecedented tricyclo[6.3.1.03,5]dodecane scaffold, was isolated from Aphania oligophylla, which is biosynthetically formed from the…”
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