The HLA‐DRB1 risk alleles for multiple sclerosis are differentially expressed in blood cells of patients from Southern Italy

The HLA‐DRB1 risk alleles for multiple sclerosis are differentially expressed in blood cells of patients from Southern Italy

HLA gene expression has an important role in the autoimmune disease predisposition. We investigated the mRNA expression profile of the risk alleles HLA‐DRB1*15 and HLA‐DRB1*13 in a cohort of subjects both multiple sclerosis (MS) patients and healthy controls. Moreover, we explored the expression of...

Full description

Saved in:
Bibliographic Details
Published in:International journal of immunogenetics Vol. 46; no. 6; pp. 479 - 484
Main Authors: Pisapia, Laura, Cerillo, Ilaria, Farina, Federica, Zimbardo, Arianna, Barba, Pasquale, Orefice, Giuseppe, Gianfrani, Carmen, Strazzullo, Maria, Del Pozzo, Giovanna
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01-12-2019
Subjects:
Adolescent
Adult
Aged
Alleles
Autoimmune diseases
autoimmunity
Blood cells
Cohort Studies
Drb1 protein
Female
Gene expression
Gene Frequency
Heterozygote
Histocompatibility antigen HLA
HLA-DRB1 Chains - blood
HLA-DRB1 Chains - genetics
HLA‐DRB1 risk alleles
Humans
Italy
Leukocytes, Mononuclear - metabolism
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis - blood
Multiple Sclerosis - genetics
Polymorphism, Single Nucleotide
Risk Factors
RNA
single nucleotide polymorphism
Young Adult
Italy
RNA
autoimmunity
single nucleotide polymorphism
HLA-DRB1 risk alleles
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:HLA gene expression has an important role in the autoimmune disease predisposition. We investigated the mRNA expression profile of the risk alleles HLA‐DRB1*15 and HLA‐DRB1*13 in a cohort of subjects both multiple sclerosis (MS) patients and healthy controls. Moreover, we explored the expression of the allele HLA‐DRB1*11 that is very frequent in our cohort from southern Italy. We found that the expression of MS‐associated alleles in heterozygous MS patients was always higher than the nonassociated alleles. The differential risk allele expression occurred also in nonaffected subjects, though with a lower increment compared to MS patients.
Bibliography:Funding information
This work was supported by CNR‐DSB Progetto Bandiera “InterOmics” 2017 and by PO FESR 2014‐2020 “SATIN” from Regione Campania.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1744-3121
1744-313X
DOI:10.1111/iji.12450