Search Results - "Zimarino, Carlo"

Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells by Zimarino, Carlo, Moody, William, Davidson, Sarah E., Munir, Hafsa, Shields, Jacqueline D.

“…Myeloid-derived suppressor cells (MDSCs) are a heterogeneous immune population with diverse immunosuppressive functions in solid tumors. Here, we explored the…”
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Generation of Fcabs targeting human and murine LAG-3 as building blocks for novel bispecific antibody therapeutics by Everett, Katy L., Kraman, Matthew, Wollerton, Francisca P.G., Zimarino, Carlo, Kmiecik, Katarzyna, Gaspar, Miguel, Pechouckova, Sarka, Allen, Natalie L., Doody, Jacqueline F., Tuna, Mihriban

“…•Phage display was used to generate Fcabs targeting human and murine LAG-3.•These Fcabs block LAG-3 binding to its target and induce activity in a T cell…”
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Abstract 5651: A LAG-3/PD-L1 bispecific antibody inhibits tumor growth in two syngeneic colon carcinoma models by Kraman, Matthew, Kmiecik, Katarzyna, Zimarino, Carlo, Everett, Katy, Faroudi, Mustapha, Wydro, Mateusz, Doody, Jacqueline

“…Combining immunotherapeutic antibodies in cancer treatment has shown benefits over single agents. An alternative to combining two antibodies is the development…”
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Abstract 2719: Dual blockade of PD-L1 and LAG-3 with FS118, a unique bispecific antibody, induces CD8+ T-cell activation and modulates the tumor microenvironment to promote antitumor immune responses by Kraman, Matthew, Fosh, Natalie, Kmiecik, Katarzyna, Everett, Katy, Zimarino, Carlo, Faroudi, Mustapha, Wydro, Mateusz, Koers, Alexander, Young, Lesley, Gliddon, Daniel, Morrow, Michelle, Doody, Jacqueline, Tuna, Mihriban, Brewis, Neil

“…Background Despite advances with therapies targeting the PD-1/PD-L1 pathway, many patients are refractory or relapse following treatment. LAG-3 expression on…”
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1353 Targeting complement factor H mediated tumor immune and complement evasion as a next generation approach by Kraman, Matthew, Zimarino, Carlo, Minns, Danielle, Dias, Jorge, Povall, Chelsea, Graves, Helen, Holub, Bradley, Minter, Ralph, Galson, Jacob, Osbourn, Jane, Finch, Donna

“…BackgroundThe complement system plays a crucial part in innate immunity, aiding the destruction of pathogens and removing anomalous cells. Complement Factor H…”
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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one by Zhang, Xiaonan, Lorent, Julie, Uemura, Marc, Tawbi, Hussein, Woodman, Scott, Bernatchez, Chantale, Logan, Theodore, Gu, Xuemin, Khushalani, Nikhil, Toth, Kyle, Carpentier, Sabrina, Galon, Jérôme, Haydu, Lauren E, Kline, Douglas, Workman, Creg, Ansa-Addo, Ephraim A, Maroto, Miguel, Chagin, Karen, Mackall, Crystal, Bennett, Alan D, Felber, Barbara, Assadipour, Yasmine, Gokuldass, Aishwarya, Hammill, Joanne, Bramson, Jonathan, Yu, Zhiya, Soon-Shiong, Patrick, Ruella, Marco, Hegde, Meenakshi, Hovgaard, Dorrit, Nguyen, Sang, Xue, Allen, Veerapathran, Anandaraman, Gunset, Gertrude, Angell, Helen K, Hodgson, Darren R, Ayers, Mark, Levitan, Diane, Liu, Fang, Yung-Jue Bang, Schalper, Kurt, Topalian, Suzanne, Conlon, Kevin, Delcommenne, Marc, Chin-Fu, Hsiao, Backert, Linus, Howells-Ferreira, Ana, Siraj, Ali, White, Eileen, Sun, Yongming, Glenn, Sean, Ehrmann, Jon M, Korman, Alan J, Reuben, Alex, Amin, Asim, Steingrimsson, Arni, Tufman, Amanda, Berger, Frank, Handy, John, Tian, Zhigang, Kulkarni, Anupriya, Edward El Rassi, Clayburgh, Daniel R, Hagberg, Hans, Zimarino, Carlo, De Bono, Johann, Özcan Met, Grossenbacher, Steven, Richards, Jon, Le, Dung T, Lee, Jean K, Leighl, Natasha, Copeland, Larry, Nam, Kijoeng, Pegram, Mark D, Juhler-Nøttrup, Trine, Tran, Ben, Qin, Zhen, Khattri, Arun, Shah, Jatin, Matsumoto, Morio, Yimer, Habte, MacKinnon, Andy, Whiting, Sam, Sondel, Paul M, Heery, Christopher R, Esteller, Manel, Park, Johanna, Leland, Pamela, Hastings, William D, Dranoff, Glenn, Bose, Nandita, Crocker, Andrea, Hartnett, Jim, Cong, Mei, Rachida-Siham Bel Aiba, Spranger, Stefani, Shukla, Sachet A, Boussiotis, Vassiliki A, Moran, Amy E

“…Adoptive Cellular TherapyO1 IL-15 primes an mTOR-regulated gene-expression program to prolong anti-tumor capacity of human natural killer cellsAndreas…”
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