Search Results - "Zilfou, Jack T"

ARF Induces Autophagy by Virtue of Interaction with Bcl-xl by Pimkina, Julia, Humbey, Olivier, Zilfou, Jack T., Jarnik, Michal, Murphy, Maureen E.

“…The ARF tumor suppressor controls a well-described p53/Mdm2-dependent oncogenic stress checkpoint. In addition, ARF has recently been shown to localize to…”
Get full text

The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer by Bosco, Emily E, Wang, Ying, Xu, Huan, Zilfou, Jack T, Knudsen, Karen E, Aronow, Bruce J, Lowe, Scott W, Knudsen, Erik S

“…The retinoblastoma tumor suppressor (RB) protein is functionally inactivated in the majority of human cancers and is aberrant in one-third of all breast…”
Get full text

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway by Hartman, Tiffiney R., Liu, Dongyan, Zilfou, Jack T., Robb, Victoria, Morrison, Tasha, Watnick, Terry, Henske, Elizabeth P.

“…Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome in which severe renal cystic disease can occur. Many renal cystic diseases, including…”
Get full text

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo by Hannon, Gregory J, Lowe, Scott W, Hemann, Michael T, Fridman, Jordan S, Zilfou, Jack T, Hernando, Eva, Paddison, Patrick J, Cordon-Cardo, Carlos

“…The application of RNA interference (RNAi) to mammalian systems has the potential to revolutionize genetics and produce novel therapies. Here we investigate…”
Get full text

Suppression of Tumorigenesis by the p53 Target PUMA by Hemann, Michael T., Zilfou, Jack T., Zhao, Zhen, Burgess, Darren J., Hannon, Gregory J., Lowe, Scott W., Stillman, Bruce W.

“…The p53 tumor suppressor regulates diverse antiproliferative processes such that cells acquiring p53 mutations have impaired cell-cycle checkpoints,…”
Get full text

The ARF tumor suppressor can promote the progression of some tumors by Humbey, Olivier, Pimkina, Julia, Zilfou, Jack T, Jarnik, Michal, Dominguez-Brauer, Carmen, Burgess, Darren J, Eischen, Christine M, Murphy, Maureen E

“…p14/p19ARF (ARF) is a tumor suppressor gene that is frequently mutated in human cancer. ARF has multiple tumor suppressor functions, some of which are mediated…”
Get full text

Tumor suppressive functions of p53 by Zilfou, Jack T, Lowe, Scott W

“…The majority of human cancers acquire mutations that abrogate the p53 tumor suppressor network and, as a consequence, p53 is one of the most extensively…”
Get full text

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53 by Hoffman, William H, Biade, Siham, Zilfou, Jack T, Chen, Jiandong, Murphy, Maureen

“…Survivin is a member of the inhibitor of apoptosis family. This apoptosis inhibitor also has an evolutionarily conserved role as a mitotic spindle checkpoint…”
Get full text

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors by Lowe, Scott W, Dickins, Ross A, Hemann, Michael T, Zilfou, Jack T, Simpson, David R, Ibarra, Ingrid, Hannon, Gregory J

“…RNA interference is a powerful method for suppressing gene expression in mammalian cells. Stable knock-down can be achieved by continuous expression of…”
Get full text

The Corepressor mSin3a Interacts with the Proline-Rich Domain of p53 and Protects p53 from Proteasome-Mediated Degradation by Zilfou, Jack T., Hoffman, William H., Sank, Michael, George, Donna L., Murphy, Maureen

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Slugging It out: Fine Tuning the p53-PUMA Death Connection by Zilfou, Jack T., Spector, Mona S., Lowe, Scott W.

“…In response to DNA damage, the tumor suppressor p53 elicits a complex cellular response. In this issue of Cell, Wu et al. (2005) show that the transcription…”
Get full text

Structure−Activity Studies of Cerulenin Analogues as Protein Palmitoylation Inhibitors by Lawrence, David S, Zilfou, Jack T, Smith, Charles D

“…Activation of ras oncogenes occurs in a high percentage of tumors, making the enzymes involved in the posttranslational processing of their encoded proteins…”
Get full text

Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs by Shen, H, Chen, Z J, Zilfou, J T, Hopper, E, Murphy, M, Tew, K D

“…The aminothiol WR-1065 (the active form of amifostine) protects normal tissues from the toxic effects of certain cancer drugs, while leaving their antitumor…”
Get more information

Inhibition of Retinoblastoma Tumor Suppressor Activity by RNA Interference in Lung Cancer Lines by Reed, Michael F., Zagorski, William A., Howington, John A., Zilfou, Jack T., Knudsen, Erik S.

“…Inactivation of retinoblastoma (RB) tumor suppressor function occurs frequently in lung cancer. Short-hairpin RNA can be constructed to target specific…”
Get full text

Circumvention of P-glycoprotein-mediated Multiple Drug Resistance by Phosphorylation Modulators Is Independent of Protein Kinases by Smith, C D, Zilfou, J T

“…Expression of P-glycoprotein by tumor cells confers resistance to multiple natural product drugs because of its ability to export these compounds. This…”
Get full text

Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53 by Hoffman, William H., Biade, Siham, Zilfou, Jack T., Chen, Jiandong, Murphy, Maureen

“…Survivin is a member of the inhibitor of apoptosis family. This apoptosis inhibitor also has an evolutionarily conserved role as a mitotic spindle checkpoint…”
Get full text

Indoloquinoxaline compounds that selectively antagonize P-glycoprotein by Smith, C D, Myers, C B, Zilfou, J T, Smith, S N, Lawrence, D S

“…Tumor cells often develop drug resistance through overexpression of membrane transport proteins that effectively efflux anticancer agents. The pharmacologies…”
Get more information

ARF Induces Autophagy by Virtue of Interaction with Bcl-xlS by Pimkina, Julia, Humbey, Olivier, Zilfou, Jack T., Jarnik, Michal, Murphy, Maureen E.

“…The ARF tumor suppressor controls a well-described p53/Mdm2-dependent oncogenic stress checkpoint. In addition, ARF has recently been shown to localize to…”
Get full text

Welwitindolinone analogues that reverse P-glycoprotein-mediated multiple drug resistance by Smith, C D, Zilfou, J T, Stratmann, K, Patterson, G M, Moore, R E

“…Welwitindolinones are a family of novel alkaloids recently isolated from the blue-green alga Hapalosiphon welwitschii as a part of our effort to identify new…”
Get more information

Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins by Smith, C D, Zilfou, J T, Zhang, X, Hudes, G R, Tew, K D

“…Estramustine previously has been shown to interact with P-glycoprotein and to restore intracellular accumulation of vinblastine and paclitaxel in cells…”
Get more information