Search Results - "Zile, Michael R."

Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association by Chow, Sheryl L, Maisel, Alan S, Anand, Inder, Bozkurt, Biykem, de Boer, Rudolf A, Felker, G Michael, Fonarow, Gregg C, Greenberg, Barry, Januzzi, James L, Kiernan, Michael S, Liu, Peter P, Wang, Thomas J, Yancy, Clyde W, Zile, Michael R

“…BACKGROUND AND PURPOSE:Natriuretic peptides have led the way as a diagnostic and prognostic tool for the diagnosis and management of heart failure (HF). More…”
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Cardiac macrophages promote diastolic dysfunction by Hulsmans, Maarten, Sager, Hendrik B, Roh, Jason D, Valero-Muñoz, María, Houstis, Nicholas E, Iwamoto, Yoshiko, Sun, Yuan, Wilson, Richard M, Wojtkiewicz, Gregory, Tricot, Benoit, Osborne, Michael T, Hung, Judy, Vinegoni, Claudio, Naxerova, Kamila, Sosnovik, David E, Zile, Michael R, Bradshaw, Amy D, Liao, Ronglih, Tawakol, Ahmed, Weissleder, Ralph, Rosenzweig, Anthony, Swirski, Filip K, Sam, Flora, Nahrendorf, Matthias

“…Macrophages populate the healthy myocardium and, depending on their phenotype, may contribute to tissue homeostasis or disease. Their origin and role in…”
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Membrane-Associated Matrix Proteolysis and Heart Failure by Spinale, Francis G, Janicki, Joseph S, Zile, Michael R

“…The extracellular matrix (ECM) is a complex entity containing a large portfolio of structural proteins, signaling molecules, and proteases. Changes in the…”
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Prognostic Implications of Changes in N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Heart Failure by Zile, Michael R., MD, Claggett, Brian L., PhD, Prescott, Margaret F., PhD, McMurray, John J.V., MD, Packer, Milton, MD, Rouleau, Jean L., MD, Swedberg, Karl, MD, Desai, Akshay S., MD, Gong, Jianjian, PhD, Shi, Victor C., MD, Solomon, Scott D., MD

“…Abstract Background Natriuretic peptides (NP) have prognostic value in heart failure (HF), although the clinical importance of changes in NP from baseline is…”
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Impaired Systolic Function by Strain Imaging in Heart Failure With Preserved Ejection Fraction by Kraigher-Krainer, Elisabeth, MD, Shah, Amil M., MD, MPH, Gupta, Deepak K., MD, Santos, Angela, MD, Claggett, Brian, PhD, Pieske, Burkert, MD, Zile, Michael R., MD, Voors, Adriaan A., MD, Lefkowitz, Marty P., MD, Packer, Milton, MD, McMurray, John J.V., MD, Solomon, Scott D., MD

“…Objectives This study sought to determine the frequency and magnitude of impaired systolic deformation in heart failure with preserved ejection fraction…”
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Relevance of Changes in Serum Creatinine during a Heart Failure Trial of Decongestive Strategies: Insights From the DOSE Trial by Brisco, Meredith A., MD, MSCE, Zile, Michael R., MD, Hanberg, Jennifer S., BA, Wilson, F. Perry, MD, MSCE, Parikh, Chirag R., MD, PhD, Coca, Steven G., DO MS, Tang, W.H. Wilson, MD, Testani, Jeffrey M., MD, MTR

“…Highlights • The validity of using changes in serum creatinine as surrogate endpoints for outcomes in heart failure was examined in 301 patients in the DOSE…”
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Natriuretic Peptides, 6-Min Walk Test, and Quality-of-Life Questionnaires as Clinically Meaningful Endpoints in HF Trials by Ferreira, João Pedro, MD, PhD, Duarte, Kevin, Msc, Graves, Todd L., PhD, Zile, Michael R., MD, Abraham, William T., MD, Weaver, Fred A., MD, Lindenfeld, JoAnn, MD, Zannad, Faiez, MD, PhD

“…Abstract The Expedited Access for Premarket Approval and De Novo Medical Devices Intended for Unmet Medical Need for Life Threatening or Irreversibly…”
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Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure by Damman, Kevin, Gori, Mauro, Claggett, Brian, Jhund, Pardeep S., Senni, Michele, Lefkowitz, Martin P., Prescott, Margaret F., Shi, Victor C., Rouleau, Jean L., Swedberg, Karl, Zile, Michael R., Packer, Milton, Desai, Akshay S., Solomon, Scott D., McMurray, John J.V.

“…The purpose of this study was to evaluate the renal effects of sacubitril/valsartan in patients with heart failure and reduced ejection fraction. Renal…”
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Health-Related Quality of Life Outcomes in PARADIGM-HF by Lewis, Eldrin F, Claggett, Brian L, McMurray, John J V, Packer, Milton, Lefkowitz, Martin P, Rouleau, Jean L, Liu, Jiankang, Shi, Victor C, Zile, Michael R, Desai, Akshay S, Solomon, Scott D, Swedberg, Karl

“…Patients with heart failure and reduced ejection fraction have impaired health-related quality of life (HRQL) with variable responses to therapies that target…”
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Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry by Tromp, Jasper, Tay, Wan Ting, Ouwerkerk, Wouter, Teng, Tiew-Hwa Katherine, Yap, Jonathan, MacDonald, Michael R, Leineweber, Kirsten, McMurray, John J V, Zile, Michael R, Anand, Inder S, Richards, A Mark, Lam, Carolyn S P

“…Comorbidities are common in patients with heart failure (HF) and complicate treatment and outcomes. We identified patterns of multimorbidity in Asian patients…”
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Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial by Seferovic, Jelena P, MD, Claggett, Brian, PhD, Seidelmann, Sara B, MD, Seely, Ellen W, MD, Packer, Milton, MD, Zile, Michael R, MD, Rouleau, Jean L, MD, Swedberg, Karl, MD, Lefkowitz, Martin, MD, Shi, Victor C, MD, Desai, Akshay S, MD, McMurray, John J V, MD, Solomon, Scott D, MD

“…Summary Background Diabetes is an independent risk factor for heart failure progression. Sacubitril/valsartan, a combination angiotensin receptor-neprilysin…”
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Diastolic Heart Failure — Abnormalities in Active Relaxation and Passive Stiffness of the Left Ventricle by Zile, Michael R, Baicu, Catalin F, Gaasch, William H

“…This hemodynamic study provides convincing evidence that heart failure in patients with a normal left ventricular ejection fraction is due to abnormal…”
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Mitochondrial biogenesis induced by the β2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury by Arif, Ehtesham, Solanki, Ashish K, Srivastava, Pankaj, Rahman, Bushra, Fitzgibbon, Wayne R, Deng, Peifeng, Budisavljevic, Milos N, Baicu, Catalin F, Zile, Michael R, Megyesi, Judit, Janech, Michael G, Kwon, Sang-Ho, Collier, Justin, Schnellmann, Rick G, Nihalani, Deepak

“…Podocytes have limited ability to recover from injury. Here, we demonstrate that increased mitochondrial biogenesis, to meet the metabolic and energy demand of…”
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Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization by Desai, Akshay S., MD, MPH, Claggett, Brian L., PhD, Packer, Milton, MD, Zile, Michael R., MD, Rouleau, Jean L., MD, Swedberg, Karl, MD, Shi, Victor, MD, Lefkowitz, Martin, MD, Starling, Randall, MD, Teerlink, John, MD, McMurray, John J.V., MD, Solomon, Scott D., MD

“…Abstract Background Patients with heart failure (HF) are at high risk for hospital readmission in the first 30 days following HF hospitalization. Objectives…”
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Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis by McDonald, Lindsay T, Zile, Michael R, Zhang, Yuhua, Van Laer, An O, Baicu, Catalin F, Stroud, Robert E, Jones, Jeffrey A, LaRue, Amanda C, Bradshaw, Amy D

“…Myocardial fibrosis and the resultant increases in left ventricular stiffness represent pivotal consequences of chronic pressure overload (PO) that impact both…”
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Left ventricle function and post-transcriptional events with exercise training in pigs by Samani, Stephanie L, Barlow, Shayne C, Freeburg, Lisa A, Jones, Traci L, Poole, Marlee, Sarzynski, Mark A, Zile, Michael R, Shazly, Tarek, Spinale, Francis G

“…Standardized exercise protocols have been shown to improve overall cardiovascular fitness, but direct effects on left ventricular (LV) function, particularly…”
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Serum potassium in the PARADIGM‐HF trial by Ferreira, João Pedro, Mogensen, Ulrik M., Jhund, Pardeep S., Desai, Akshay S., Rouleau, Jean‐Lucien, Zile, Michael R., Rossignol, Patrick, Zannad, Faiez, Packer, Milton, Solomon, Scott D., McMurray, John J.V.

“…Aims The associations between potassium level and outcomes, the effect of sacubitril–valsartan on potassium level, and whether potassium level modified the…”
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Systolic and Diastolic Mechanics in Stress Cardiomyopathy by Medeiros, Keith, O’Connor, Mark J, Baicu, Catalin F, Fitzgibbons, Timothy P, Shaw, Peter, Tighe, Dennis A, Zile, Michael R, Aurigemma, Gerard P

“…BACKGROUND—Stress cardiomyopathy (SCM) is a peculiar form of reversible left ventricular dysfunction seen predominantly in women and occurs in response to…”
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Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium by Toba, Hiroe, de Castro Brás, Lisandra E, Baicu, Catalin F, Zile, Michael R, Lindsey, Merry L, Bradshaw, Amy D

“…Secreted protein acidic and rich in cysteine (SPARC) is a collagen-binding matricellular protein highly expressed during fibrosis. Fibrosis is a prominent…”
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Comparing LCZ696 With Enalapril According to Baseline Risk Using the MAGGIC and EMPHASIS-HF Risk Scores by Simpson, Joanne, MBChB, Jhund, Pardeep S., MBChB, PhD, Silva Cardoso, Jose, PhD, Martinez, Felipe, MD, Mosterd, Arend, MD, Ramires, Felix, MD, Rizkala, Adel R., PharmD, Senni, Michele, MD, Squire, Iain, MD, Gong, Jianjian, PhD, Lefkowitz, Martin P., MD, Shi, Victor C., MD, Desai, Akshay S., MD, Rouleau, Jean L., MD, Swedberg, Karl, MD, Zile, Michael R., MD, McMurray, John J.V., MD, Packer, Milton, MD, Solomon, Scott D., MD

“…Abstract Background Although most patients in the PARADIGM-HF (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity…”
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