Search Results - "Zilberter, Y."

Pyramidal cell communication within local networks in layer 2/3 of rat neocortex by Holmgren, Carl, Harkany, Tibor, Svennenfors, Björn, Zilberter, Yuri

“…The extent to which neocortical pyramidal cells function as a local network is determined by the strength and probability of their connections. By mapping…”
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Metabolic correction by pyruvate halts acquired epilepsy in multiple rodent models by Popova, I., Malkov, A., Ivanov, A.I., Samokhina, E., Buldakova, S., Gubkina, O., Osypov, A., Muhammadiev, R.S., Zilberter, T., Molchanov, M., Paskevich, S., Zilberter, M., Zilberter, Y.

“…Metabolic intervention strategy of epilepsy treatment has been gaining broader attention due to accumulated evidence that hypometabolism, manifested in humans…”
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Dendritic release of glutamate suppresses synaptic inhibition of pyramidal neurons in rat neocortex by Zilberter, Y.

“…Dual whole-cell recordings were made in layer 2/3 of the rat neocortex in synaptically connected pyramidal cells and fast-spiking non-accommodating (FSN)…”
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Back-propagating action potentials mediate calcium signalling in dendrites of bitufted interneurons in layer 2/3 of rat somatosensory cortex by Kaiser, Katharina M. M., Zilberter, Y., Sakmann, B.

“…Bitufted interneurons in layer 2/3 of the rat (P14) somatosensory cortex have elongated apical and basal dendritic arbors that can span the entire depth of the…”
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(R)-roscovitine, a cyclin-dependent kinase inhibitor, enhances tonic GABA inhibition in rat hippocampus by Ivanov, A, Tyzio, R, Zilberter, Y, Ben-Ari, Yehezkel

“…Abstract Pharmacological agents that mediate a persistent GABAergic conductance are of considerable interest for treatment of epilepsy. (R)-roscovitine is a…”
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Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons by Harkany, Tibor, Härtig, Wolfgang, Berghuis, Paul, Dobszay, Marton B., Zilberter, Yuri, Edwards, Robert H., Mackie, Ken, Ernfors, Patrik

“…Basal forebrain cholinergic neurons project to diverse cortical and hippocampal areas and receive reciprocal projections therefrom. Maintenance of a fine‐tuned…”
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Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4 -related Alzheimer's disease by Taubes, Alice, Nova, Phil, Zalocusky, Kelly A, Kosti, Idit, Bicak, Mesude, Zilberter, Misha Y, Hao, Yanxia, Yoon, Seo Yeon, Oskotsky, Tomiko, Pineda, Silvia, Chen, Bin, Jones, Emily A Aery, Choudhary, Krishna, Grone, Brian, Balestra, Maureen E, Chaudhry, Fayzan, Paranjpe, Ishan, De Freitas, Jessica, Koutsodendris, Nicole, Chen, Nuo, Wang, Celine, Chang, William, An, Alice, Glicksberg, Benjamin S, Sirota, Marina, Huang, Yadong

“…The evident genetic, pathological, and clinical heterogeneity of Alzheimer's disease (AD) poses challenges for traditional drug development. We conducted a…”
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Breakfast and cognition: sixteen effects in nine populations, no single recipe by Zilberter, Tanya, Zilberter, Eugene Y

“…In this opinion article, we argue against the prevalent viewpoint of the universal benefits of BF by selectively highlighting issues demonstrating the…”
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Proarrhythmic response to potassium channel blockade : numerical studies of polymorphic tachyarrhythmias by STARMER, C. F, ROMASHKO, D. N, REDDY, R. S, ZILBERTER, Y. I, STAROBIN, J, GRANT, A. O, KRINSKY, V. I

“…Prompted by the results of CAST results, attention has shifted from class I agents that primarily block sodium channels to class III agents that primarily…”
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Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia by Ernfors, Patrik, Lucas, Guilherme, Hendolin, Panu, Harkany, Tibor, Agerman, Karin, Paratcha, Gustavo, Holmgren, Carl, Zilberter, Yuri, Sairanen, Mikko, Minichiello, Liliana, Castren, Eero

“…Morphine is a powerful analgesic for severe pain, and this effect is thought to be mediated by inhibitory G-protein coupled receptors (GPCRs). Here we show…”
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Effects of short-term synaptic plasticity in a local microcircuit on cell firing by Eriksson, David, Fransén, Erik, Zilberter, Yuri, Lansner, Anders

“…Effects of short-term synaptic plasticity on cell firing properties in a microcircuit formed by a reciprocally connected pyramidal cell and FSN interneuron in…”
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Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy by Minkeviciene, Rimante, Rheims, Sylvain, Dobszay, Marton B, Zilberter, Misha, Hartikainen, Jarmo, Fülöp, Lívia, Penke, Botond, Zilberter, Yuri, Harkany, Tibor, Pitkänen, Asla, Tanila, Heikki

“…Alzheimer's disease is associated with an increased risk of unprovoked seizures. However, the underlying mechanisms of seizure induction remain elusive. Here,…”
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Author Correction: Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease by Taubes, Alice, Nova, Phil, Zalocusky, Kelly A, Kosti, Idit, Bicak, Mesude, Zilberter, Misha Y, Hao, Yanxia, Yoon, Seo Yeon, Oskotsky, Tomiko, Pineda, Silvia, Chen, Bin, Aery Jones, Emily A, Choudhary, Krishna, Grone, Brian, Balestra, Maureen E, Chaudhry, Fayzan, Paranjpe, Ishan, De Freitas, Jessica, Koutsodendris, Nicole, Chen, Nuo, Wang, Celine, Chang, William, An, Alice, Glicksberg, Benjamin S, Sirota, Marina, Huang, Yadong

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Glycolysis and Oxidative Phosphorylation in Neurons and Astrocytes during Network Activity in Hippocampal Slices by Ivanov, Anton I, Malkov, Anton E, Waseem, Tatsiana, Mukhtarov, Marat, Buldakova, Svetlana, Gubkina, Olena, Zilberter, Misha, Zilberter, Yuri

“…Network activation triggers a significant energy metabolism increase in both neurons and astrocytes. Questions of the primary neuronal energy substrate (e.g.,…”
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Chronic inhibition of brain glycolysis initiates epileptogenesis by Samokhina, Evgeniya, Popova, Irina, Malkov, Anton, Ivanov, Anton I., Papadia, Daniela, Osypov, Alexander, Molchanov, Maxim, Paskevich, Svetlana, Fisahn, André, Zilberter, Misha, Zilberter, Yuri

“…Metabolic abnormalities found in epileptogenic tissue provide considerable evidence of brain hypometabolism, while major risk factors for acquired epilepsy all…”
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Adenosine receptor antagonists including caffeine alter fetal brain development in mice by Silva, Carla G, Métin, Christine, Fazeli, Walid, Machado, Nuno J, Darmopil, Sanja, Launay, Pierre-Serge, Ghestem, Antoine, Nesa, Marie-Pascale, Bassot, Emilie, Szabó, Eszter, Baqi, Younis, Müller, Christa E, Tomé, Angelo R, Ivanov, Anton, Isbrandt, Dirk, Zilberter, Yuri, Cunha, Rodrigo A, Esclapez, Monique, Bernard, Christophe

“…Consumption of certain substances during pregnancy can interfere with brain development, leading to deleterious long-term neurological and cognitive…”
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Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease by Zilberter, Misha, Ivanov, Anton, Ziyatdinova, Sofya, Mukhtarov, Marat, Malkov, Anton, Alpár, Alan, Tortoriello, Giuseppe, Botting, Catherine H., Fülöp, Lívia, Osypov, Alex A., Pitkänen, Asla, Tanila, Heikki, Harkany, Tibor, Zilberter, Yuri

“…Deficient energy metabolism and network hyperactivity are the early symptoms of Alzheimer's disease (AD). In this study, we show that administration of…”
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Open Na+ channel blockade: multiple rest states revealed by channel interactions with disopyramide and quinidine by Zilberter, Y I, Starmer, C F, Grant, A O

“…In voltage-clamp studies of atrial myocytes exposed to disopyramide or quinidine, pulse-train stimulation revealed use-dependent block that increased with…”
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Desensitization of N-methyl-D-aspartate receptors in neurons dissociated from adult rat hippocampus by Zilberter, Y, Uteshev, V, Sokolova, S, Khodorov, B

“…Desensitization of the N-methyl-D-aspartate (NMDA) receptor-channel complex was studied in isolated rat hippocampal neurons using a fast drug application…”
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Wavelet formation in excitable cardiac tissue: the role of wavefront-obstacle interactions in initiating high-frequency fibrillatory-like arrhythmias by Starobin, J.M., Zilberter, Y.I., Rusnak, E.M., Starmer, C.F.

“…High-frequency arrhythmias leading to fibrillation are often associated with the presence of inhomogeneities (obstacles) in cardiac tissue and reduced…”
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