Search Results - "Zilbershtein, Timur M."

Decene formation in ethylene trimerization reaction catalyzed by Cr–pyrrole system by Zilbershtein, Timur M., Kardash, Vladislav A., Suvorova, Vladlena V., Golovko, Anatoly K.

“…•Isomeric decenes were formed in accordance with metallacyclic mechanism.•There are hexene-dependent and hexene-independent decene formation…”
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Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O, Parkhill, Eric Q, Vasilevich, Natalya I, Glushkov, Andrei I, Zilbershtein, Timur M, Ivanov, Alexei V, Cole, Andrew G, Henderson, Ian, Zautke, Nathan A, Brunn, Sandra A, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W, Zablocki, Jeff

“…We identified a series of structurally novel SCD (Delta9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the…”
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Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Zilbershtein, Timur M., Migulin, Vasily A., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., McGregor, Malcolm J., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…Two structurally distinct series of SCD (Δ9 desaturase) inhibitors (1 and 2) have been previously reported by our group. In the present work, we merged the…”
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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., Zilbershtein, Timur M., Mayboroda, Elena I., Boze, Melanie A., Cole, Andrew G., Henderson, Ian, Zautke, Nathan A., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…We discovered a structurally novel SCD inhibitor CVT-11,563 (IC50 119nM, HEPG2 assay), selective against Δ5 and Δ6 desaturases, with excellent PK parameters…”
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Decene formation in ethylene trimerization reaction catalyzed by Cr―pyrrole system by ZILBERSHTEIN, Timur M, KARDASH, Vladislav A, SUVOROVA, Vladlena V, GOLOVKO, Anatoly K

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Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, ZILBERSHTEIN, Timur M, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, MIGULIN, Vasily A, VASILEVICH, Natalya I, PARKHILL, Eric Q, GLUSHKOV, Andrei I, MCGREGOR, Malcolm J, BRUNN, Sandra A, CHU, Nancy, JIA HAO

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Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, PARKHILL, Eric Q, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, VASILEVICH, Natalya I, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, IVANOV, Alexei V, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A, BRUNN, Sandra A

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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, VASILEVICH, Natalya I, BRUNN, Sandra A, CHU, Nancy, JIA HAO, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, PARKHILL, Eric Q, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, MAYBORODA, Elena I, BOZE, Melanie A, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A

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