Search Results - "Zilbermintz, Leeor"

Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting by Zilbermintz, Leeor, Leonardi, William, Jeong, Sun-Young, Sjodt, Megan, McComb, Ryan, Ho, Chi-Lee C., Retterer, Cary, Gharaibeh, Dima, Zamani, Rouzbeh, Soloveva, Veronica, Bavari, Sina, Levitin, Anastasia, West, Joel, Bradley, Kenneth A., Clubb, Robert T., Cohen, Stanley N., Gupta, Vivek, Martchenko, Mikhail

“…A longstanding and still-increasing threat to the effective treatment of infectious diseases is resistance to antimicrobial countermeasures. Potentially, the…”
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Trypanosoma brucei Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity by Brown, Robert W B, Sharma, Aabha I, Villanueva, Miguel Rey, Li, Xiaomo, Onguka, Ouma, Zilbermintz, Leeor, Nguyen, Helen, Falk, Ben A, Olson, Cheryl L, Taylor, Joann M, Epting, Conrad L, Kathayat, Rahul S, Amara, Neri, Dickinson, Bryan C, Bogyo, Matthew, Engman, David M

“…Dynamic post-translational modifications allow the rapid, specific, and tunable regulation of protein functions in eukaryotic cells. -acylation is the only…”
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Repurposing FDA approved drugs against the human fungal pathogen, Candida albicans by Kim, Kevin, Zilbermintz, Leeor, Martchenko, Mikhail

“…The high cost and prolonged timeline of new drug discovery and development are major roadblocks to creating therapies for infectious diseases. Candida albicans…”
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Bithionol blocks pathogenicity of bacterial toxins, ricin and Zika virus by Leonardi, William, Zilbermintz, Leeor, Cheng, Luisa W., Zozaya, Josue, Tran, Sharon H., Elliott, Jeffrey H., Polukhina, Kseniya, Manasherob, Robert, Li, Amy, Chi, Xiaoli, Gharaibeh, Dima, Kenny, Tara, Zamani, Rouzbeh, Soloveva, Veronica, Haddow, Andrew D., Nasar, Farooq, Bavari, Sina, Bassik, Michael C., Cohen, Stanley N., Levitin, Anastasia, Martchenko, Mikhail

“…Diverse pathogenic agents often utilize overlapping host networks and hub proteins within these networks represent attractive targets for broad-spectrum drugs…”
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Cross-inhibition of pathogenic agents and the host proteins they exploit by Zilbermintz, Leeor, Leonardi, William, Tran, Sharon H., Zozaya, Josue, Mathew-Joseph, Alyssa, Liem, Spencer, Levitin, Anastasia, Martchenko, Mikhail

“…The major limitations of pathogen-directed therapies are the emergence of drug-resistance and their narrow spectrum of coverage. A recently applied approach…”
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ITrypanosoma brucei/I Acyl-Protein Thioesterase-like Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity by Brown, Robert W. B, Sharma, Aabha I, Villanueva, Miguel Rey, Li, Xiaomo, Onguka, Ouma, Zilbermintz, Leeor, Nguyen, Helen, Falk, Ben A, Olson, Cheryl L, Taylor, Joann M, Epting, Conrad L, Kathayat, Rahul S, Amara, Neri, Dickinson, Bryan C, Bogyo, Matthew, Engman, David M

“…Dynamic post-translational modifications allow the rapid, specific, and tunable regulation of protein functions in eukaryotic cells. S-acylation is the only…”
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In Vivo Activity of Repurposed Amodiaquine as a Host-Targeting Therapy for the Treatment of Anthrax by Martchenko Shilman, Mikhail, Bartolo, Gloria, Alameh, Saleem, Peterson, Johnny W, Lawrence, William S, Peel, Jennifer E, Sivasubramani, Satheesh K, Beasley, David W. C, Cote, Christopher K, Demons, Samandra T, Halasahoris, Stephanie A, Miller, Lynda L, Klimko, Christopher P, Shoe, Jennifer L, Fetterer, David P, McComb, Ryan, Ho, Chi-Lee C, Bradley, Kenneth A, Hartmann, Stella, Cheng, Luisa W, Chugunova, Marina, Kao, Chiu-Yen, Tran, Jennifer K, Derbedrossian, Aram, Zilbermintz, Leeor, Amali-Adekwu, Emiene, Levitin, Anastasia, West, Joel

“…Anthrax is caused by Bacillus anthracis and can result in nearly 100% mortality due in part to anthrax toxin. Antimalarial amodiaquine (AQ) acts as a…”
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