Search Results - "Zigman, W"

Obesity, diabetes and their metabolic correlates in middle‐aged adults with Down syndrome by Luchsinger, J. A., Pang, D., Krinsky‐McHale, S. J., Schupf, N., Lee, J. H., Silverman, W., Zigman, W. B.

“…Background Obesity in adults without Down syndrome is associated with an adverse metabolic profile including high prevalence of pre‐diabetes and diabetes, high…”
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Change in plasma Aβ peptides and onset of dementia in adults with Down syndrome by SCHUPF, N, ZIGMAN, W. B, TANG, M.-X, PANG, D, MAYEUX, R, MEHTA, P, SILVERMAN, W

“…Objective: To examine changes in levels of plasma amyloid- beta (A beta ) peptides, A beta 42 and A beta 40, in relation to onset of Alzheimer disease (AD) in…”
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Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down Syndrome by Prasher, V. P., Sajith, S. G., Rees, S. D., Patel, A., Tewari, S., Schupf, N., Zigman, W. B.

“…Objective Virtually all adults with Down syndrome (DS) have neuropathological manifestations of Dementia in Alzheimer's disease (DAD) but not all develop…”
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Plasma β-amyloid and duration of Alzheimer's disease in adults with Down syndrome by Prasher, V. P., Sajith, S. G., Mehta, P., Zigman, W. B., Schupf, N.

“…Objectives To investigate the relation of plasma levels of Aβ peptides (Aβ1‐40 and Aβ1‐42) and apolipoprotein E (APOE) genotype to dementia status, and the…”
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An improved method for detecting telomere size differences in T-lymphocyte interphases from older people with Down syndrome with and without mild cognitive impairment by Jenkins, E. C., Ye, L., Marchi, E., Krinsky-McHale, S. J., Zigman, W. B., Schupf, N., Silverman, W. P.

“…Abstract Telomere size (quantified by fluorescence intensity and physical lengths) in short-term T-lymphocyte cultures from adults with Down syndrome (DS) with…”
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Early menopause in women with Down's syndrome by Schupf, N., Zigman, W., Kapell, D., Lee, J. H., Kline, J., Levin, B.

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Elevated plasma amyloid β-peptide 1–42 and onset of dementia in adults with Down syndrome by Schupf, Nicole, Patel, Bindu, Silverman, Wayne, Zigman, Warren B., Zhong, Nan, Tycko, Benjamin, Mehta, Pankaj D., Mayeux, Richard

“…We compared levels of plasma amyloid β-peptides Aβ1–42 and Aβ1–40 in 108 demented and nondemented adults with Down syndrome (DS) and 64 adults from the general…”
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The epidemiology of Alzheimer disease in intellectual disability: results and recommendations from an international conference by Zigman, W., Schupf, N., Haveman, M., Silverman, W.

“…Among adults with intellectual disability, virtually everyone with Down's syndrome (DS) over the age of 40 years has neuropathology currently viewed to be…”
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Dementia of the Alzheimer's type and accelerated aging in Down syndrome by Devenny, D A, Wegiel, J, Schupf, N, Jenkins, E, Zigman, W, Krinsky-McHale, S J, Silverman, W P

“…This case study, of a woman with Down syndrome and dementia of the Alzheimer's type (DAT), follows the course of her decline over an 11-year period until death…”
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Alzheimer neuropathology in mentally retarded adults : statistical independence of regional amyloid plaque and neurofibrillary tangle densities by SILVERMAN, W, POPOVITCH, E, SCHUPF, N, ZIGMAN, W. B, RABE, A, SERSEN, E, WISNIEWSKI, H. M

“…The densities of neurofibrillary tangles (NFT) and neuritic plaques (NP) were assessed quantitatively in the brains of 303 mentally retarded adults 23 to 90…”
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Prevalence of Dementia in Adults with and without Down Syndrome by Zigman, Warren B

“…Comparison of adults with mental retardation either with or without Down syndrome and under or over 50 years of age found a significantly higher rate of…”
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Early menopause in women with Down's syndrome by Schupf, N., Zigman, W., Kapell, D., Lee, J. H., Kline, J., Levin, B.

“…We used the AAMR's Adaptive Behavior Scale to ascertain current menstrual status in a population‐based sample of 157 women with Down's syndrome (DS) and 187…”
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Prevalence of Chronic Medical Conditions in Adults with Mental Retardation: Comparison with the General Population by Kapell, Deborah, Nightingale, Beryle, Rodriguez, Ana, Lee, Joseph H, Zigman, Warren B, Schupf, Nicole

“…A study interviewed caregivers and reviewed medical records of 278 adults with mental retardation with and without Down syndrome. The adults with mental…”
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Plasma Delta b-amyloid and duration of Alzheimer's disease in adults with Down syndrome by Prasher, V P, Sajith, S G, Mehta, P, Zigman, W B, Schupf, N

“…Objectives To investigate the relation of plasma levels of A peptides (A1-40 and A1-42) and apolipoprotein E (APOE) genotype to dementia status, and the…”
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Plasma [beta]-amyloid and duration of Alzheimer's disease in adults with Down syndrome by Prasher, V P, Sajith, S G, Mehta, P, Zigman, W B, Schupf, N

“…To investigate the relation of plasma levels of Aβ peptides (Aβ1-40 and Aβ1-42) and apolipoprotein E (APOE) genotype to dementia status, and the duration of…”
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Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome by Schupf, Nicole, Lee, Joseph H, Wei, Michelle, Pang, Deborah, Chace, Constance, Cheng, Rong, Zigman, Warren B, Tycko, Benjamin, Silverman, Wayne

“…Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). Two tightly linked polymorphisms (PvuII and XbaI) in the…”
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Behavioral Capabilities and Mortality Risk in Adults with and without Down Syndrome by Stauss, David, Zigman, Warren B

“…Adults with mental retardation (n=22,740) were studied to investigate age-related changes in functioning and their relation to subsequent mortality…”
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Premature regression of adults with Down syndrome by Zigman, W B, Schupf, N, Lubin, R A, Silverman, W P

“…Adaptive skills of 2,144 individuals with Down syndrome were compared to a similar group of 4,172 developmentally disabled people without Down syndrome…”
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Change in plasma Aß peptides and onset of dementia in adults with Down syndrome by Schupf, N, Zigman, W B, Tang, M-X, Pang, D, Mayeux, R, Mehta, P, Silverman, W

“…To examine changes in levels of plasma amyloid-β (Aβ) peptides, Aβ42 and Aβ40, in relation to onset of Alzheimer disease (AD) in adults with Down syndrome…”
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Physical and environmental design characteristics of community residences by Janicki, M P, Zigman, W B

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