Search Results - "Ziegler, K. G"

Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes by Genshaft, Alex S, Ziegler, Carly G. K., Tzouanas, Constantine N., Mead, Benjamin E., Jaeger, Alex M., Navia, Andrew W., King, Ryan P., Mana, Miyeko D., Huang, Siyi, Mitsialis, Vanessa, Snapper, Scott B., Yilmaz, Ömer H., Jacks, Tyler, Van Humbeck, Jeffrey F., Shalek, Alex K.

“…A cell’s phenotype and function are influenced by dynamic interactions with its microenvironment. To examine cellular spatiotemporal activity, we developed…”
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Publisher Correction: Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes by Genshaft, Alex S., Ziegler, Carly G. K., Tzouanas, Constantine N., Mead, Benjamin E., Jaeger, Alex M., Navia, Andrew W., King, Ryan P., Mana, Miyeko D., Huang, Siyi, Mitsialis, Vanessa, Snapper, Scott B., Yilmaz, Ömer H., Jacks, Tyler, Van Humbeck, Jeffrey F., Shalek, Alex K.

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Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses by Douam, Florian, Ziegler, Carly G. K., Hrebikova, Gabriela, Fant, Bruno, Leach, Robert, Parsons, Lance, Wang, Wei, Gaska, Jenna M., Winer, Benjamin Y., Heller, Brigitte, Shalek, Alex K., Ploss, Alexander

“…Mice engrafted with components of a human immune system have become widely-used models for studying aspects of human immunity and disease. However, a defined…”
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Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction by Genshaft, Alex S, Li, Shuqiang, Gallant, Caroline J, Darmanis, Spyros, Prakadan, Sanjay M, Ziegler, Carly G K, Lundberg, Martin, Fredriksson, Simon, Hong, Joyce, Regev, Aviv, Livak, Kenneth J, Landegren, Ulf, Shalek, Alex K

“…We present a scalable, integrated strategy for coupled protein and RNA detection from single cells. Our approach leverages the DNA polymerase activity of…”
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Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip by Bein, Amir, Kim, Seongmin, Goyal, Girija, Cao, Wuji, Fadel, Cicely, Naziripour, Arash, Sharma, Sanjay, Swenor, Ben, LoGrande, Nina, Nurani, Atiq, Miao, Vincent N, Navia, Andrew W, Ziegler, Carly G K, Montañes, José Ordovas, Prabhala, Pranav, Kim, Min Sun, Prantil-Baun, Rachelle, Rodas, Melissa, Jiang, Amanda, O'Sullivan, Lucy, Tillya, Gladness, Shalek, Alex K, Ingber, Donald E

“…Many patients infected with coronaviruses, such as SARS-CoV-2 and NL63 that use ACE2 receptors to infect cells, exhibit gastrointestinal symptoms and viral…”
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Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection by Kazer, Samuel W., Aicher, Toby P., Muema, Daniel M., Carroll, Shaina L., Ordovas-Montanes, Jose, Miao, Vincent N., Tu, Ang A., Ziegler, Carly G. K., Nyquist, Sarah K., Wong, Emily B., Ismail, Nasreen, Dong, Mary, Moodley, Amber, Berger, Bonnie, Love, J. Christopher, Dong, Krista L., Leslie, Alasdair, Ndhlovu, Zaza M., Ndung’u, Thumbi, Walker, Bruce D., Shalek, Alex K.

“…Cellular immunity is critical for controlling intracellular pathogens, but individual cellular dynamics and cell–cell cooperativity in evolving human immune…”
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Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells by Palomba, M Lia, Piersanti, Kelly, Ziegler, Carly G K, Decker, Hugo, Cotari, Jesse W, Bantilan, Kurt, Rijo, Ivelise, Gardner, Jeff R, Heaney, Mark, Bemis, Debra, Balderas, Robert, Malek, Sami N, Seymour, Erlene, Zelenetz, Andrew D, van den Brink, Marcel R M, Altan-Bonnet, Grégoire

“…Chronic Lymphocytic Leukemia (CLL) is defined by a perturbed B-cell receptor-mediated signaling machinery. We aimed to model differential signaling behavior…”
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Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response by Rodel, Hylton E, Ferreira, Isabella A T M, Ziegler, Carly G K, Ganga, Yashica, Bernstein, Mallory, Hwa, Shi-Hsia, Nargan, Kievershen, Lustig, Gila, Kaplan, Gilla, Noursadeghi, Mahdad, Shalek, Alex K, Steyn, Adrie J C, Sigal, Alex

“…(Mtb) bacilli readily aggregate. We previously reported that Mtb aggregates lead to phagocyte death and subsequent efficient replication in the dead infected…”
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Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention by Furlan, Scott N, Watkins, Benjamin, Tkachev, Victor, Flynn, Ryan, Cooley, Sarah, Ramakrishnan, Swetha, Singh, Karnail, Giver, Cindy, Hamby, Kelly, Stempora, Linda, Garrett, Aneesah, Chen, Jingyang, Betz, Kayla M, Ziegler, Carly G K, Tharp, Gregory K, Bosinger, Steven E, Promislow, Daniel E L, Miller, Jeffrey S, Waller, Edmund K, Blazar, Bruce R, Kean, Leslie S

“…Graft-versus-host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular…”
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Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism by Fung, Thomas C., Bessman, Nicholas J., Hepworth, Matthew R., Kumar, Nitin, Shibata, Naoko, Kobuley, Dmytro, Wang, Kelvin, Ziegler, Carly G.K., Goc, Jeremy, Shima, Tatsuichiro, Umesaki, Yoshinori, Sartor, R. Balfour, Sullivan, Kaede V., Lawley, Trevor D., Kunisawa, Jun, Kiyono, Hiroshi, Sonnenberg, Gregory F.

“…Physical separation between the mammalian immune system and commensal bacteria is necessary to limit chronic inflammation. However, selective species of…”
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Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis by Alenghat, Theresa, Osborne, Lisa C., Saenz, Steven A., Kobuley, Dmytro, Ziegler, Carly G. K., Mullican, Shannon E., Choi, Inchan, Grunberg, Stephanie, Sinha, Rohini, Wynosky-Dolfi, Meghan, Snyder, Annelise, Giacomin, Paul R., Joyce, Karen L., Hoang, Tram B., Bewtra, Meenakshi, Brodsky, Igor E., Sonnenberg, Gregory F., Bushman, Frederic D., Won, Kyoung-Jae, Lazar, Mitchell A., Artis, David

“…This work identifies a role for intestinal epithelial cell (IEC)-intrinsic expression of histone deacetylase 3 in regulating commensal-bacteria-dependent gene…”
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IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells by Saenz, Steven A, Siracusa, Mark C, Monticelli, Laurel A, Ziegler, Carly G K, Kim, Brian S, Brestoff, Jonathan R, Peterson, Lance W, Wherry, E John, Goldrath, Ananda W, Bhandoola, Avinash, Artis, David

“…The predominantly epithelial cell-derived cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) can promote CD4(+) Th2 cell-dependent immunity,…”
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Computational algorithm-driven evaluation of monocytic myeloid-derived suppressor cell frequency for prediction of clinical outcomes by Kitano, Shigehisa, Postow, Michael A, Ziegler, Carly G K, Kuk, Deborah, Panageas, Katherine S, Cortez, Czrina, Rasalan, Teresa, Adamow, Mathew, Yuan, Jianda, Wong, Philip, Altan-Bonnet, Gregoire, Wolchok, Jedd D, Lesokhin, Alexander M

“…Evaluation of myeloid-derived suppressor cells (MDSC), a cell type implicated in T-cell suppression, may inform immune status. However, a uniform methodology…”
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Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells by Hubbard-Lucey, Vanessa M., Shono, Yusuke, Maurer, Katie, West, Mallory L., Singer, Natalie V., Ziegler, Carly G.K., Lezcano, Cecilia, Motta, Ana Carolina Fragoso, Schmid, Karin, Levi, Samuel M., Murphy, George F., Liu, Chen, Winkler, Jeffrey D., Amaravadi, Ravi K., Rogler, Gerhard, Dickinson, Anne M., Holler, Ernst, van den Brink, Marcel R.M., Cadwell, Ken

“…Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with…”
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Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential by Huang, Siyi, Ziegler, Carly G.K., Austin, John, Mannoun, Najat, Vukovic, Marko, Ordovas-Montanes, Jose, Shalek, Alex K., von Andrian, Ulrich H.

“…Barrier tissue immune responses are regulated in part by nociceptors. Nociceptor ablation alters local immune responses at peripheral sites and within draining…”
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Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria by Hepworth, Matthew R., Monticelli, Laurel A., Fung, Thomas C., Ziegler, Carly G. K., Grunberg, Stephanie, Sinha, Rohini, Mantegazza, Adriana R., Ma, Hak-Ling, Crawford, Alison, Angelosanto, Jill M., Wherry, E. John, Koni, Pandelakis A., Bushman, Frederic D., Elson, Charles O., Eberl, Gérard, Artis, David, Sonnenberg, Gregory F.

“…Group 3 innate lymphoid cells are shown to process and present antigen and to control CD4 + T-cell responses to intestinal commensal bacteria through an…”
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Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus by Monticelli, Laurel A, Sonnenberg, Gregory F, Abt, Michael C, Alenghat, Theresa, Ziegler, Carly G K, Doering, Travis A, Angelosanto, Jill M, Laidlaw, Brian J, Yang, Cliff Y, Sathaliyawala, Taheri, Kubota, Masaru, Turner, Damian, Diamond, Joshua M, Goldrath, Ananda W, Farber, Donna L, Collman, Ronald G, Wherry, E John, Artis, David

“…Cytokine-producing innate lymphoid cells are found at mucosal surfaces. Artis and Wherry and their colleagues show that innate 'nuocyte-like' cells accumulate…”
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An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection by Ziegler, Carly G K, Owings, Anna H, Galeas-Pena, Michelle, Kazer, Samuel W, Miao, Vincent N, Navia, Andrew W, Tang, Ying, Bromley, Joshua D, Lotfy, Peter, Sloan, Meredith, Laird, Hannah, Williams, Haley B, George, Micayla, Drake, Riley S, Pride, Yilianys, Abraham, 3rd, George E, Senitko, Michal, Robinson, Tanya O, Diamond, Gill, Lionakis, Michail S, Shalek, Alex K, Ordovas-Montanes, Jose, Horwitz, Bruce H, Glover, Sarah C

“…Recent case reports and epidemiological data suggest that fungal infections represent an underappreciated complication among people with severe COVID-19…”
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Constitutive Activation of the B Cell Receptor Underlies Dysfunctional Signaling in Chronic Lymphocytic Leukemia by Ziegler, Carly G.K., Kim, Joel, Piersanti, Kelly, Oyler-Yaniv, Alon, Argyropoulos, Kimon V., van den Brink, Marcel R.M., Palomba, M. Lia, Altan-Bonnet, Nihal, Altan-Bonnet, Grégoire

“…In cancer biology, the functional interpretation of genomic alterations is critical to achieve the promise of genomic profiling in the clinic. For chronic…”
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Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses by Shono, Yusuke, Tuckett, Andrea Z, Liou, Hsiou-Chi, Doubrovina, Ekaterina, Derenzini, Enrico, Ouk, Samedy, Tsai, Jennifer J, Smith, Odette M, Levy, Emily R, Kreines, Fabiana M, Ziegler, Carly G K, Scallion, Mary I, Doubrovin, Mikhail, Heller, Glenn, Younes, Anas, O'Reilly, Richard J, van den Brink, Marcel R M, Zakrzewski, Johannes L

“…NF-κB plays a variety of roles in oncogenesis and immunity that may be beneficial for therapeutic targeting, but strategies to selectively inhibit NF-κB to…”
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