Search Results - "Ziegler, Daniel M"

AN OVERVIEW OF THE MECHANISM, SUBSTRATE SPECIFICITIES, AND STRUCTURE OF FMOs by Ziegler, Daniel M.

“…Kinetic studies carried out over the past three decades, primarily with purified pig liver flavin-containing monooxygenase (FMO1), demonstrated that the…”
Get full text

Yeast flavin-containing monooxygenase generates oxidizing equivalents that control protein folding in the endoplasmic reticulum by Suh, J.K, Poulsen, L.L, Ziegler, D.M, Robertus, J.D

“…The flavin-containing monooxygenase from yeast (yFMO) catalyzes the O(2)- and NADPH-dependent oxidations of biological thiols, including oxidation of…”
Get full text

Lysine 219 Participates in NADPH Specificity in a Flavin-Containing Monooxygenase from Saccharomyces cerevisiae by Suh, Jung-Keun, Poulsen, Lawrence L, Ziegler, Daniel M, Robertus, Jon D

“…The flavin-containing monooxygenase from Saccharomyces cerevisiae (yFMO) uses NADPH and O2 to oxidize thiol containing substrates such as GSH and thereby…”
Get full text

N-Glycosylation of Pig Flavin-Containing Monooxygenase Form 1:  Determination of the Site of Protein Modification by Mass Spectrometry by Korsmeyer, Katy K, Guan, Shengheng, Yang, Zi-Cheng, Falick, Arnold M, Ziegler, Daniel M, Cashman, John R

“…By using a combination of biochemical methods (i.e., endoglycosidase H digestion and immunoblot and plant lectin binding studies), it was verified that pig…”
Get full text

Inhibition of Purified and Membrane-Bound Flavin-Containing Monooxygenase 1 by (N,N-Dimethylamino)stilbene Carboxylates by Clement, Bernd, Weide, Matthias, Ziegler, Daniel M

“…(E)-[2-(4-(Dimethylamino)phenyl)vinyl]benzenes bearing a nitrile or carboxyl group in the 2‘, 3‘, or 4‘ position were synthesized and tested for substrate…”
Get full text

Molecular Cloning and Kinetic Characterization of a Flavin-Containing Monooxygenase fromSaccharomyces cerevisiae by Suh, Jung-Keun, Poulsen, Lawrence L., Ziegler, Daniel M., Robertus, Jon D.

“…An open reading frame from yeast coding for a homologue of flavin containing monooxygenase (FMO) has been cloned into severalEscherichia coliexpression…”
Get full text

Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases by Ziegler, D M

Get full text

NADPH-dependent oxidation of reduced ebselen, 2-selenylbenzanilide, and of 2-(methylseleno)benzanilide catalyzed by pig liver flavin-containing monooxygenase by Ziegler, Daniel M, Graf, Peter, Poulsen, Lawrence L, Sies, Helmut, Stahl, Wilhelm

Get full text

AN OVERVIEW OF THE MECHANISM, SUBSTRATE SPECIFICITIES, AND STRUCTURE OF FMO s by Ziegler, Daniel M.

Get full text

The enzymes of detoxication by Jakoby, W B, Ziegler, D M

“…The problem of dealing with the nutritionally useless compounds that inevitably find their way into tissues is entirely different for higher forms of life…”
Get full text

Recursively Summarizing Books with Human Feedback by Wu, Jeff, Ouyang, Long, Ziegler, Daniel M, Stiennon, Nisan, Lowe, Ryan, Leike, Jan, Christiano, Paul

“…A major challenge for scaling machine learning is training models to perform tasks that are very difficult or time-consuming for humans to evaluate. We present…”
Get full text

Size Limits of Thiocarbamides Accepted as Substrates by Human Flavin-Containing Monooxygenase 1 by YOUNG MI KIM, ZIEGLER, D. M

“…Microsomes isolated from Spodoptera frugiperda (Sf)9 cells infected with human flavin-containing monooxygenase (FMO)1 recombinant baculovirus catalyzed the…”
Get full text

Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity by Ziegler, D M

“…Unlike all other oxidases, microsomal flavin-containing monooxygenases (FMO) discriminate between essential and foreign compounds by excluding the former…”
Get more information

Adversarial Training for High-Stakes Reliability by Ziegler, Daniel M, Nix, Seraphina, Chan, Lawrence, Bauman, Tim, Schmidt-Nielsen, Peter, Lin, Tao, Scherlis, Adam, Nabeshima, Noa, Weinstein-Raun, Ben, de Haas, Daniel, Shlegeris, Buck, Thomas, Nate

“…In the future, powerful AI systems may be deployed in high-stakes settings, where a single failure could be catastrophic. One technique for improving AI safety…”
Get full text

The distinct nature and function of NADPH-cytochrome c reductase and the NADPH-dependent mixed-function amine oxidase of porcine liver microsomes by Masters, B S, Ziegler, D M

Get more information

Sleeper Agents: Training Deceptive LLMs that Persist Through Safety Training by Hubinger, Evan, Denison, Carson, Mu, Jesse, Lambert, Mike, Tong, Meg, MacDiarmid, Monte, Lanham, Tamera, Ziegler, Daniel M, Maxwell, Tim, Cheng, Newton, Jermyn, Adam, Askell, Amanda, Radhakrishnan, Ansh, Anil, Cem, Duvenaud, David, Ganguli, Deep, Barez, Fazl, Clark, Jack, Ndousse, Kamal, Sachan, Kshitij, Sellitto, Michael, Sharma, Mrinank, DasSarma, Nova, Grosse, Roger, Kravec, Shauna, Bai, Yuntao, Witten, Zachary, Favaro, Marina, Brauner, Jan, Karnofsky, Holden, Christiano, Paul, Bowman, Samuel R, Graham, Logan, Kaplan, Jared, Mindermann, Sören, Greenblatt, Ryan, Shlegeris, Buck, Schiefer, Nicholas, Perez, Ethan

“…Humans are capable of strategically deceptive behavior: behaving helpfully in most situations, but then behaving very differently in order to pursue…”
Get full text

Learning to summarize from human feedback by Stiennon, Nisan, Ouyang, Long, Wu, Jeff, Ziegler, Daniel M, Lowe, Ryan, Voss, Chelsea, Radford, Alec, Amodei, Dario, Christiano, Paul

“…As language models become more powerful, training and evaluation are increasingly bottlenecked by the data and metrics used for a particular task. For example,…”
Get full text

Permeability of Adolescent Rat Intestine to Pancreatic Ribonuclease by Urban, Ernest, Zingery, Amy Ahrens, Bundrant, Teril, Weser, Elliot, Ziegler, Daniel M

“…There are indications that exocrine pancreatic enzymes may undergo an enteric recirculation. Ribonuclease (RNase) is present in considerable quantities in…”
Get full text

Fine-Tuning Language Models from Human Preferences by Ziegler, Daniel M, Stiennon, Nisan, Wu, Jeffrey, Brown, Tom B, Radford, Alec, Amodei, Dario, Christiano, Paul, Irving, Geoffrey

“…Reward learning enables the application of reinforcement learning (RL) to tasks where reward is defined by human judgment, building a model of reward by asking…”
Get full text

A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities by Lawton, M P, Cashman, J R, Cresteil, T, Dolphin, C T, Elfarra, A A, Hines, R N, Hodgson, E, Kimura, T, Ozols, J, Phillips, I R

“…A nomenclature based on comparisons of amino acid sequences is proposed for the members of the mammalian flavin-containing monooxygenase (FMO) gene family…”
Get more information