Search Results - "Ziegelaar, Brian"

Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis by Henderson, Robert D., Agosti, Jan M., McCombe, Pamela A., Thorpe, Kathryn, Heggie, Susan, Heshmat, Saman, Appleby, Mark W., Ziegelaar, Brian W., Crowe, David T., Redlich, Garry L.

“…The primary objective was to demonstrate the safety and tolerability of monoclonal antibody against CD14 (IC14) (atibuclimab) in amyotrophic lateral sclerosis…”
Get full text

Artificial cornea by Chirila, Traian V., Hicks, Celia R., Dalton, Paul D., Vijayasekaran, Sarojini, Lou, Xia, Hong, Ye, Clayton, Anthony B., Ziegelaar, Brian W., Fitton, J.Helen, Platten, Sharon, Crawford, Geoffrey J., Constable, Ian J.

“…Under normal physiological conditions, the cornea is able to maintain indefinitely its own integrity and transparency. However, it is also the most vulnerable…”
Get full text

Abstract 18289: A Real-World Analysis Of New-Onset Heart Failure After Anterior Wall ST-Elevation Acute Myocardial Infarction by Van Tassell, Benjamin W, Talasaz, Azita, Abbate, Antonio, Ziegelaar, Brian, Redlich, Garry

“…Abstract only Introduction: The one-year incidence of heart failure (HF) after anterior wall ST-elevation acute myocardial infarction (STEMI) remains difficult…”
Get full text

A Real-World Analysis of New-Onset Heart Failure After Anterior Wall ST-Elevation Acute Myocardial Infarction in the United States by Van Tassell, Benjamin, Talasaz, Azita H, Redlich, Garry, Ziegelaar, Brian, Abbate, Antonio

“…The 1-year incidence of heart failure (HF) after anterior wall ST-elevation acute myocardial infarction (STEMI) remains difficult to determine because of…”
Get full text

The characterisation of human respiratory epithelial cells cultured on resorbable scaffolds: first steps towards a tissue engineered tracheal replacement by Ziegelaar, Brian W., Aigner, Joachim, Staudenmaier, Rainer, Lempart, Kathrin, Mack, Brigitte, Happ, Theda, Sittinger, Michael, Endres, Michaela, Naumann, Andreas, Kastenbauer, Ernst, Rotter, Nicole

“…In this study we have used lectin histochemistry and scanning electron microscopy (SEM) to assess the growth and characterise the differentiation of human…”
Get full text

Safety and activity of anti‐CD14 antibody IC14 (atibuclimab) in ALS: Experience with expanded access protocol by Gelevski, Dario, Addy, Grace, Rohrer, Margot, Cohen, Caroline, Roderick, Aimee, Winter, Allison, Carey, Judith, Scalia, Jennifer, Yerton, Megan, Weber, Harli, Doyle, Michael, Parikh, Neil, Kane, Geli, Ellrodt, Amy, Burke, Katherine, D'Agostino, Derek, Sinani, Ervin, Yu, Hong, Sherman, Alexander, Agosti, Jan, Redlich, Garry, Charmley, Patrick, Crowe, David, Appleby, Mark, Ziegelaar, Brian, Hanus, Katherine, Li, Zhenhua, Babu, Suma, Nicholson, Katharine, Luppino, Sarah, Berry, James, Baecher‐Allan, Clare, Paganoni, Sabrina, Cudkowicz, Merit

“…Introduction/Aims IC14 (atibuclimab) is a monoclonal anti‐CD14 antibody. A previous phase 1 trial of 10 participants with amyotrophic lateral sclerosis (ALS)…”
Get full text

The modulation of corneal keratocyte and epithelial cell responses to poly(2-hydroxyethyl methacrylate) hydrogel surfaces: phosphorylation decreases collagenase production in vitro by Ziegelaar, Brian W, Helen Fitton, J, Clayton, Anthony B, Platten, Sharon T, Maley, Moira A.L, Chirila, Traian V

“…We examined the regulation of collagenase production by rabbit keratocyte, epithelial and mixed keratocyte/epithelial cell cultures which were exposed to…”
Get full text

Assessment of anticollagenase treatments after insertion of a keratoprosthetic material in the rabbit cornea by Fitton, J H, Ziegelaar, B W, Hicks, C R, Clayton, A B, Crawford, G J, Constable, I J, Chirila, T V

“…This study was performed to evaluate the enzyme production in response to implantation of the hydrogel material used in the experimental Chirila…”
Get more information

Effect of crosslinked poly(1-vinyl-2-pyrrolidinone) gels on cell growth in static cell cultures by Hong, Y, Chirila, T V, Fitton, J H, Ziegelaar, B W, Constable, I J

“…Poly(1-vinyl-2-pyrrolidinone) (PVP) and copolymers of 1-vinyl-2-pyrrolidinone are insoluble in water when crosslinked but they can absorb very large amounts of…”
Get more information

Clinical results of implantation of the Chirila keratoprosthesis in rabbits by Hicks, Celia R, Chirila, Traian V, Clayton, Anthony B, Fitton, J Helen, Vijayasekaran, Sarojini, Dalton, Paul D, Lou, Xia, Platten, Sharon, Ziegelaar, Brian, Hong, Ye, Crawford, Geoffrey J, Constable, Ian J

“…AIMS/BACKGROUND An ideal keratoprosthesis (KPro) would closely resemble a donor corneal button in terms of its surgical handling, optics, and capacity to heal…”
Get full text

The modulation of cellular responses to poly(2-hydroxyethyl methacrylate) hydrogel surfaces: phosphorylation decreases macrophage collagenase production in vitro by Ziegelaar, Brian W., Fitton, J. Helen, Clayton, Anthony B., Platten, Sharon T., Steer, Jay, Chirila, Traian V.

“…We examined the regulation of collagenase production by the monocyte/macrophage THP-1 cell line when these cells were exposed to poly(2-hydroxyethyl…”
Get full text

Hydrophilic Sponges Based on 2-Hydroxyethyl Methacrylate. VI. Effect of Phase Sequence Inversion on the Characteristics of IPN between Sponges and Homogeneous Gels by Chirila, Traian V., Lou, Xia, Vijayasekaran, Sarojini, Ziegelaar, Brian W., Hong, Ye, Clayton, Anthony B.

“…Poly (2-hydroxyethyl methacrylate) (PHEMA) is currently used as a prosthetic polymer in an artificial cornea consisting of a skirt made of a PHEMA sponge…”
Get full text