Search Results - "Ziebell, Michael R"

Affinity selection-mass spectrometry screening techniques for small molecule drug discovery by Annis, D. Allen, Nickbarg, Elliot, Yang, Xianshu, Ziebell, Michael R., Whitehurst, Charles E.

“…Affinity selection-mass spectrometry (AS-MS) techniques assess the binding of candidate molecules to immobilized or soluble receptors, and these methods are…”
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Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for [3H]Azietomidate, a Photoactivatable General Anesthetic by Ziebell, Michael R., Nirthanan, Selvanayagam, Husain, S. Shaukat, Miller, Keith W., Cohen, Jonathan B.

“…To identify binding domains in a ligand-gated ion channel for etomidate, an intravenous general anesthetic, we photolabeled nicotinic acetylcholine receptor…”
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Structural characterization of nonactive site, TrkA-selective kinase inhibitors by Su, Hua-Poo, Rickert, Keith, Burlein, Christine, Narayan, Kartik, Bukhtiyarova, Marina, Hurzy, Danielle M., Stump, Craig A., Zhang, Xufang, Reid, John, Krasowska-Zoladek, Alicja, Tummala, Srivanya, Shipman, Jennifer M., Kornienko, Maria, Lemaire, Peter A., Krosky, Daniel, Heller, Amanda, Achab, Abdelghani, Chamberlin, Chad, Saradjian, Peter, Sauvagnat, Berengere, Yang, Xianshu, Ziebell, Michael R., Nickbarg, Elliott, Sanders, John M., Bilodeau, Mark T., Carroll, Steven S., Lumb, Kevin J., Soisson, Stephen M., Henze, Darrell A., Cooke, Andrew J.

“…Current therapies for chronic pain can have insufficient efficacy and lead to side effects, necessitating research of novel targets against pain. Although…”
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[3H]Chlorpromazine Photolabeling of the Torpedo Nicotinic Acetylcholine Receptor Identifies Two State-Dependent Binding Sites in the Ion Channel by Chiara, David C, Hamouda, Ayman K, Ziebell, Michael R, Mejia, Luis A, Garcia, Galo, Cohen, Jonathan B

“…Chlorpromazine (CPZ), a potent nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist, binds with higher affinity in the ion channel in the…”
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A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells by Luo, Y, Ziebell, M R, Prestwich, G D

“…A cell-targeted polymeric prodrug prepared from Taxol and chemically modified hyaluronic acid (HA) was evaluated in vitro. Herein we report four results in…”
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Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives by Prestwich, Glenn D, Marecak, Dale M, Marecek, James F, Vercruysse, Koen P, Ziebell, Michael R

“…Controlled modification of the carboxylic acid moieties of hyaluronic acid with mono- and polyfunctional hydrazides leads to biochemical probes, biopolymers…”
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2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate:  A Derivative of the Stereoselective General Anesthetic Etomidate for Photolabeling Ligand-Gated Ion Channels by Husain, S. Shaukat, Ziebell, Michael R, Ruesch, Dirk, Hong, Filbert, Arevalo, Enrique, Kosterlitz, Jonathan A, Olsen, Richard W, Forman, Stuart A, Cohen, Jonathan B, Miller, Keith W

“…To locate general anesthetic binding sites on ligand-gated ion channels, a diazirine derivative of the potent intravenous anesthetic, R-(+)-etomidate (2-ethyl…”
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Interactions of peptide mimics of hyaluronic acid with the receptor for hyaluronan mediated motility (RHAMM) by Ziebell, Michael R, Prestwich, Glenn D

“…Using the hyaluronic acid (HA) binding region of the receptor for hyaluronan-mediated motility (RHAMM) as a model, a molecular perspective for peptide mimicry…”
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Discovery and characterization of orthosteric and allosteric muscarinic M2 acetylcholine receptor ligands by affinity selection-mass spectrometry by Whitehurst, Charles E, Nazef, Naim, Annis, D Allen, Hou, Yongmin, Murphy, Denise M, Spacciapoli, Peter, Yao, Zhiping, Ziebell, Michael R, Cheng, Cliff C, Shipps, Jr, Gerald W, Felsch, Jason S, Lau, David, Nash, Huw M

“…Screening assays using target-based affinity selection coupled with high-sensitivity detection technologies to identify small-molecule hits from chemical…”
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Photolabeling the Torpedo Nicotinic Acetylcholine Receptor with 4-Azido-2,3,5,6-tetrafluorobenzoylcholine, a Partial Agonist by Nirthanan, Selvanayagam, Ziebell, Michael R, Chiara, David C, Hong, Filbert, Cohen, Jonathan B

“…The interactions of a photoreactive analogue of benzoylcholine, 4-azido-2,3,5,6-tetrafluorobenzoylcholine (APFBzcholine), with nicotinic acetylcholine…”
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Identification of Amino Acids in the Nicotinic Acetylcholine Receptor Agonist Binding Site and Ion Channel Photolabeled by 4-[(3-Trifluoromethyl)-3H-Diazirin-3-yl]Benzoylcholine, a Novel Photoaffinity Antagonist by Chiara, David C, Trinidad, Jonathan C, Wang, Dong, Ziebell, Michael R, Sullivan, Deirdre, Cohen, Jonathan B

“…[3H]4-[(3-trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine (TDBzcholine) was synthesized and used as a photoaffinity probe to map the orientation of an…”
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Control of enzymatic degradation of hyaluronan by divalent cations by Vercruysse, Koen P., Ziebell, Michael R., Prestwich, Glenn D.

“…Enzymatic degradation of hyaluronan (HA) by testicular hyaluronidase (HAase, hyaluronate 4-glucanohydrolase) requires inclusion of mono- or divalent cations in…”
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Peptides that mimic glycosaminoglycans: high-affinity ligands for a hyaluronan binding domain by Ziebell, Michael R, Zhao, Zhan-Gong, Luo, Bai, Luo, Yi, Turley, Eva A, Prestwich, Glenn D

“…Background: Hyaluronan (HA) is a non-sulfated glycosaminoglycan (GAG) that promotes motility, adhesion, and proliferation in mammalian cells, as mediated by…”
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2-(3-Methyl-3 H -diaziren-3-yl)ethyl 1-(1-phenylethyl)-1 H -imidazole-5-carboxylate:  A Derivative of the Stereoselective General Anesthetic Etomidate for Photolabeling Ligand-Gated Ion Channels by Husain, S. Shaukat, Ziebell, Michael R., Ruesch, Dirk, Hong, Filbert, Arevalo, Enrique, Kosterlitz, Jonathan A., Olsen, Richard W., Forman, Stuart A., Cohen, Jonathan B., Miller, Keith W.

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