Search Results - "Zieba, Jacob K."
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Diffusion in intact secondary cell wall models of plants at different equilibrium moisture content
Published in Cell surface (Amsterdam) (01-12-2023)“…Secondary plant cell walls are composed of carbohydrate and lignin polymers, and collectively represent a significant renewable resource. Leveraging these…”
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Gene Therapy for Genetic Syndromes: Understanding the Current State to Guide Future Care
Published in Biotech (Basel) (03-01-2024)“…Gene therapy holds promise as a life-changing option for individuals with genetic variants that give rise to disease. FDA-approved gene therapies for Spinal…”
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High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N -oxide
Published in Science (American Association for the Advancement of Science) (13-08-2021)“…A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut…”
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Salmonella enterica serovar Typhimurium uses anaerobic respiration to overcome propionate-mediated colonization resistance
Published in Cell reports (Cambridge) (04-01-2022)“…The gut microbiota benefits the host by limiting enteric pathogen expansion (colonization resistance), partially via the production of inhibitory metabolites…”
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An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism
Published in Cell host & microbe (11-10-2023)“…The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse…”
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Salmonella Typhimurium expansion in the inflamed murine gut is dependent on aspartate derived from ROS-mediated microbiota lysis
Published in Cell host & microbe (12-06-2024)“…Inflammation boosts the availability of electron acceptors in the intestinal lumen, creating a favorable niche for pathogenic Enterobacteriaceae. However, the…”
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Evolutionary Landscape of SOX Genes to Inform Genotype-to-Phenotype Relationships
Published in Genes (14-01-2023)“…The SOX transcription factor family is pivotal in controlling aspects of development. To identify genotype-phenotype relationships of SOX proteins, we…”
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