Search Results - "Zidar, Mitja"

High Throughput Prediction Approach for Monoclonal Antibody Aggregation at High Concentration by Zidar, Mitja, Šušterič, Ana, Ravnik, Miha, Kuzman, Drago

“…Purpose Characterization of the monoclonal antibody aggregation process and identification of stability factors that could be used as indicators of aggregation…”
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Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability by Lebar, Blaž, Zidar, Mitja, Mravljak, Janez, Šink, Roman, Žula, Aleš, Pajk, Stane

“…The formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and…”
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Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies by Proj, Matic, Zidar, Mitja, Lebar, Blaž, Strašek, Nika, Miličić, Goran, Žula, Aleš, Gobec, Stanislav

“…[Display omitted] •Computational screening yielded 44 new viscosity-reducing agents on two model mAbs.•Dual excipients for viscosity reduction and solution…”
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Control of viscosity in biopharmaceutical protein formulations by Zidar, Mitja, Rozman, Petruša, Belko-Parkel, Kaja, Ravnik, Miha

“…[Display omitted] Controlling the viscosity of concentrated protein solutions – usually reducing – is an open challenge, with major recent relevance in protein…”
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Small scale model for predicting transportation-induced particle formation in biotherapeutics by Strnad, Urška Pečarič, Zalokar, Petra, Osterman, Natan, Zidar, Mitja

“…Understanding protein adsorption and aggregation at the air-liquid interfaces of protein solutions is an important open challenge in biopharmaceutical,…”
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Polysorbate stability: Effects of packaging materials, buffers, counterions, and pH by Lebar, Blaž, Lekić, Tinkara, Košir, Pija, Kastelic, Miha, Zidar, Mitja, Mravljak, Janez, Pajk, Stane

“…[Display omitted] •Leachables from plastic containers fully suppress chemical hydrolysis of PS.•Results suggest base-catalysed hydrolysis of PS in histidine,…”
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Surfaces Affect Screening Reliability in Formulation Development of Biologics by Zidar, Mitja, Posnjak, Gregor, Muševič, Igor, Ravnik, Miha, Kuzman, Drago

“…Purpose The ability to predict an antibody’s propensity for aggregation is particularly important during product development to ensure the quality and safety…”
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A multifaceted approach to understanding protein-buffer interactions in biopharmaceuticals by Lebar, Blaž, Orehova, Maria, Japelj, Boštjan, Šprager, Ernest, Podlipec, Rok, Knaflič, Tilen, Urbančič, Iztok, Knez, Benjamin, Zidar, Mitja, Cerar, Jure, Mravljak, Janez, Žula, Aleš, Arčon, Denis, Plavec, Janez, Pajk, Stane

“…[Display omitted] The excipient selection process plays a crucial role in biopharmaceutical formulation development to ensure the long-term stability of the…”
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