Bone characteristics and metabolic phenotypes of obesity in an Iranian Elderly population: Bushehr Elderly Health Program (BEHP)

Introduction Obesity and osteoporosis are health problems with high impact on the morbidity and mortality rate. While the association between BMI and bone density is known, the combined effects of obesity and metabolic components on bone health have not yet been revealed. The objectives of this stud...

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Bibliographic Details
Published in:	Archives of osteoporosis Vol. 16; no. 1
Main Authors:	Amininezhad, Farzaneh, Payab, Moloud, Sharifi, Farshad, Ostovar, Afshin, Mehrdad, Neda, Heshmat, Ramin, Hadizadeh, Alireza, Bagherzadeh, Mohammad, Shafiee, Gita, Shadman, Zhaleh, Ziaei, Sedigheh, Hajipour, Firouzeh, Khashayar, Patricia, Nabipour, Iraj, Larijani, Bagher, Ebrahimpur, Mahbube
Format:	Journal Article
Language:	English
Published:	London Springer London 01-12-2021
Subjects:	Endocrinology Medicine Medicine & Public Health Original Article Orthopedics Abdominal obesity Obesity Osteoporosis Metabolic phenotype General obesity Metabolic syndrome
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Summary:	Introduction Obesity and osteoporosis are health problems with high impact on the morbidity and mortality rate. While the association between BMI and bone density is known, the combined effects of obesity and metabolic components on bone health have not yet been revealed. The objectives of this study were to determine the association between bone health and different phenotypes of obesity in an elderly population. Methods This cross-sectional study was conducted on the data collected in the Bushehr Elderly Health Program (BEHP). The participants were classified in four groups based on the metabolic phenotypes of obesity (metabolic healthy obese (MHO), metabolic non-healthy non-obese (MNHNO), metabolic non-healthy obese (MNHO), and metabolic healthy non-obese (MHNO)). The association between osteoporosis and TBS and the metabolic phenotypes of obesity were assessed using multiple variable logistic regression models. Results Totally, 2378 people (1227 women) were considered for analyses. The prevalence of MHNO, MHO, MNHNO, and MNHO were 902 (39.9%), 138 (6.1%), 758 (33.5%), and 464 (20.5%), respectively. In the multivariate logistic regression models, those with MHO (OR 0.22; 95% CI 0.12–0.36), MNHNO (OR 0.52; 95% CI 0.4–0.66), and MNHO phenotypes (OR 0.22; 95% CI 0.16–0.3) had a significantly lower risk of osteoporosis. Likewise, those having MHO (OR 2.38; 95% CI 1.51–3.76), MNHNO (OR 1.49; 95% CI 1.11–2), and MNHO (OR 2.50; 95% CI 1.82–3.42) phenotypes were found to had higher risk of low bone quality as confirmed by TBS. Conclusions The obese subjects have lower bone quality, regardless of their obesity phenotype.
ISSN:	1862-3522 1862-3514
DOI:	10.1007/s11657-021-00953-2