Association of Angiotensin-Converting Enzyme gene polymorphism in Pakistani women with the atypical steroidogenesis in Polycystic ovarian syndrome: A case-control study

Polymorphism in the angiotensin-converting enzyme gene (ACE) is responsible for elevated ACE concentrations in plasma. High ACE levels induce insulin resistance and hyperandrogenism, which are the main attributes of polycystic ovary syndrome (PCOS). Therefore, it was hypothesized that I/D polymorphi...

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Published in:	Saudi journal of biological sciences Vol. 28; no. 6; pp. 3483 - 3489
Main Authors:	Nazeer, Kiran, Munawar Lone, Nasira, Sadique, Shumaila, Sultan, Sikandar, Zia Eupash, Amna, Riaz, Saba
Format:	Journal Article
Language:	English
Published:	Riyadh, Saudi Arabia Elsevier B.V 01-06-2021 Saudi Biological Society Elsevier
Subjects:	Gene polymorphism Hyperandrogenism LH: FSH ratio Original Polycystic ovarian syndrome Renin-angiotensin system Vit ACE IR:Insulin resistanceRAS LH: FSH ratio Renin-angiotensin system WC EDTA Gene polymorphism CVD A-II ROS HWE Polycystic ovarian syndrome Hyperandrogenism FSH SPSS LH PCO Ca PCR BMI EDTA, Ethylenediamine tetraacetic acid Vit, Vitamin FSH, Follicular stimulating hormone Ca, Calcium BMI, Body mass index SPSS, Statistical Package for Social Sciences LH, Leutinizing hormone HWE, Hardy-weinberg equilibrium ACE, Angiotensin-converting enzyme ROS, Reactive oxygen specie PCR, Polymerase chain reaction WC, Waist circumference CVD, Cardiovascular diseases PCO, Polycystic ovarian syndrome IR:Insulin resistanceRAS, Renin-Angiotensin System A-II, Angiotensin-II
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Summary:	Polymorphism in the angiotensin-converting enzyme gene (ACE) is responsible for elevated ACE concentrations in plasma. High ACE levels induce insulin resistance and hyperandrogenism, which are the main attributes of polycystic ovary syndrome (PCOS). Therefore, it was hypothesized that I/D polymorphism plays a role in the pathogenesis of PCOS. A case-control study was designed to investigate the association of I/D polymorphism of the ACE gene with PCOS in Pakistani women of reproductive age. ACE I/D polymorphism was assessed in 252 women of age group 16–40 years. For genotypic analysis, PCR amplification of genomic DNA was carried out. Statistical analysis was performed to interpret the results using SPSS software. Our study showed that PCOS women were more likely to have a high body mass index and waist circumferences. Most PCOS patients had menstrual irregularities 99.3%, hirsutism 75.2% and cysts in ovaries 66.6%, along with other hyperandrogenic conditions (P-value = 0.001). The genotypic and allelic frequencies were significantly different between patients and controls. There was a significant association of three genotypes with the ratio of LH: FSH among PCOS patients (P = 0.05). Anthropometric characters, comorbidities, clinical symptoms, and PCOS conditions showed no statistical significance with ACE polymorphism. ACE I/D polymorphism was not found associated with clinical conditions of PCOS in women of reproductive age. However, it was associated with atypical steroidogenesis. So, it indicates that ACE I/D polymorphism aggravates the pathogenesis of PCOS.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1319-562X 2213-7106
DOI:	10.1016/j.sjbs.2021.03.014