Search Results - "Zhuxi Chen"
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Structure of the CCR5 Chemokine Receptor—HIV Entry Inhibitor Maraviroc Complex
Published in Science (American Association for the Advancement of Science) (20-09-2013)“…The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the 2.7 angstrom-resolution crystal structure of human CCR5 bound to…”
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Dynamic PIP₂ interactions with voltage sensor elements contribute to KCNQ2 channel gating
Published in Proceedings of the National Academy of Sciences - PNAS (10-12-2013)“…The S4 segment and the S4–S5 linker of voltage-gated potassium (Kv) channels are crucial for voltage sensing. Previous studies on the Shaker and Kv1.2 channels…”
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Binding Competition to the POPG Lipid Bilayer of Ca2+, Mg2+, Na+, and K+ in Different Ion Mixtures and Biological Implication
Published in The journal of physical chemistry. B (24-01-2013)“…Ion mixtures are prevalent in both cytosol and the exterior of a plasma membrane with variable compositions and concentrations. Although abundant MD…”
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The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands
Published in Cell research (01-09-2013)“…Voltage-gated potassium (Kv) channels derive their voltage sensitivity from movement of gating charges in volt- age-sensor domains (VSDs). The gating charges…”
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A bi-directional flow-rack automated storage and retrieval system for unit-load warehouses
Published in International journal of production research (18-07-2015)“…Flow-rack is a multi-deep rack containing multi-row and multi-column slope bins. Traditionally, bins slope in the same direction in a flow-rack to make…”
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Predicting human plasma protein binding of drugs using plasma protein interaction QSAR analysis (PPI-QSAR)
Published in Biopharmaceutics & drug disposition (01-09-2011)“…ABSTRACT A novel method, named as the plasma protein‐interaction QSAR analysis (PPI‐QSAR) was used to construct the QSAR models for human plasma protein…”
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A RFID-based dual-command method for unit-load warehouse systems
Published in 2011 IEEE International Conference on Systems, Man, and Cybernetics (01-10-2011)“…In this paper, a RFID-based method is proposed for resource localization and dual-command generation in unit-load warehouse environments. A novel framework is…”
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Conference Proceeding -
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Evaluation of biochar addition and circulation control strengthening measures on efficiency and microecology of food waste treatment in anaerobic reactor
Published in Journal of environmental management (01-11-2021)“…The process of strengthening an expanded granular sludge blanket (EGSB) reactor under ammonia nitrogen stress conditions and by adopting three strengthening…”
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Impacts of different organophosphorus flame retardants on the transformation of phosphorus forms and microbial metabolic pathways in anaerobic reactors
Published in Journal of water process engineering (01-08-2024)“…Organophosphorus flame retardants are widely distributed in aquatic environment and wastewater treatment plants. However, their effect on biological wastewater…”
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Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation
Published in Scientific reports (15-10-2015)“…Published studies of lipid-protein interactions have mainly focused on lipid binding to an individual site of the protein. Here, we show that a lipid can…”
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Journal Article -
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Two-Quartet G‑Quadruplexes Formed by DNA Sequences Containing Four Contiguous GG Runs
Published in The journal of physical chemistry. B (05-03-2015)“…The DNA sequence containing four contiguous GG runs (G2N x G2N y G2N z G2, G2 sequence) has the potential to form a two-quartet G-quadruplex. However, the…”
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Sequencing the storages and retrievals for flow-rack automated storage and retrieval systems with duration-of-stay storage policy
Published in International journal of production research (16-02-2016)“…Sequencing of storages and retrievals is an important topic in the automated storage and retrieval system (AS/RS), which largely influences the throughput…”
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Characterizing the binding of annexin V to a lipid bilayer using molecular dynamics simulations
Published in Proteins, structure, function, and bioinformatics (01-02-2014)“…ABSTRACT Annexins play critical roles in membrane organization, membrane trafficking and vesicle transport. The family members share the ability to bind to…”
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An Activator Binding Site in the Gating Charge Pathway of KCNQ2 Channel
Published in Biophysical journal (28-01-2014)Get full text
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Dynamic PIP 2 interactions with voltage sensor elements contribute to KCNQ2 channel gating
Published in Proceedings of the National Academy of Sciences - PNAS (10-12-2013)“…Significance Many membrane protein functions require phosphatidylinositol-4,5-bisphosphate (PIP 2 ), a minor phospholipid in the inner leaflet of plasma…”
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Journal Article -
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Dynamic PIP2interactions with voltage sensor elements contribute to KCNQ2 channel gating
Published in Proceedings of the National Academy of Sciences - PNAS (10-12-2013)“…The S4 segment and the S4–S5 linker of voltage-gated potassium (Kv) channels are crucial for voltage sensing. Previous studies on the Shaker and Kv1.2 channels…”
Get full text
Journal Article -
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Dynamic PIP^sub 2^ interactions with voltage sensor elements contribute to KCNQ2 channel gating
Published in Proceedings of the National Academy of Sciences - PNAS (10-12-2013)“…The S4 segment and the S4-S5 linker of voltage-gated potassium (Kv) channels are crucial for voltage sensing. Previous studies on the Shaker and Kv1.2 channels…”
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Journal Article -
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Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2)
Published in Bioorganic & medicinal chemistry letters (01-06-2016)“…[Display omitted] The discovery and optimization of a series of indazole amide based extracellular signal-regulated kinase inhibitors via structure/knowledge…”
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Binding Competition to the POPG Lipid Bilayer of Ca super(2+), Mg super(2+), Na super(+), and K super(+) in Different Ion Mixtures and Biological Implication
Published in The journal of physical chemistry. B (04-01-2013)“…Ion mixtures are prevalent in both cytosol and the exterior of a plasma membrane with variable compositions and concentrations. Although abundant MD…”
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Journal Article