Search Results - "Zhuo, Linsheng"

Discovery of 8-Amino-Substituted 2-Phenyl-2,7-Naphthyridinone Derivatives as New c-Kit/VEGFR-2 Kinase Inhibitors by Sun, Haiyan, Zhuo, Linsheng, Dong, Huan, Huang, Wei, She, Nengfang

“…The 2,7-naphthyridone scaffold has been proposed as a novel lead structure of MET inhibitors by our group. To broaden the application of this new scaffold, a…”
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Development of o -aminobenzamide salt derivatives for improving water solubility and anti-undifferentiated gastric cancer by Li, Shuang, He, Yanli, Li, Xuelin, Xiong, Yongxia, Peng, Yan, Wang, Chengkun, Zhuo, Linsheng, Jiang, Weifan, Lu, Xianzhou, Wang, Zhen

“…Gastric cancer is one of the cancers with wide incidence, difficult treatment and high mortality in the world, especially in Asia and Africa. In our previous…”
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From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disorders by Wu, Junbo, Zhang, Honghua, Wang, Yuying, Yin, Gaofeng, Li, Qien, Zhuo, Linsheng, Chen, Hongjin, Wang, Zhen

“…A novel class of benzyl-free and benzyl-substituted carbamylated tryptamine derivatives (CDTs) was designed and synthesized to serve as effective building…”
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Novel N-phenyl-2-(aniline) benzamide hydrochloride salt development for colon cancer therapy by Peng, Yan, Peng, Ying, Zhang, Wei, Zhang, Siyi, Peng, Huiqian, Li, Zhen, Li, Bo, Liu, Linyi, Zhuo, Linsheng, Wang, Zhen, Wu, Junbo, Jiang, Weifan

“…Introduction N -phenyl-2-(aniline) analog N53 is a previously discovered dual inhibitor of Topo I and COX-2, which exhibited significant anti-colon cancer…”
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Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor by Sun, Shouyuan, Shi, Tao, Peng, Yan, Zhang, Honghua, Zhuo, Linsheng, Peng, Xue, Li, Qien, Wang, Manxia, Wang, Shuzhi, Wang, Zhen

“…Inspired by the crucial roles of (hetero)aryl rings in cholinesterase inhibitors and the pyrrole ring in new drug discovery, we synthesized 19 pyrrole…”
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Auto In Silico Ligand Directing Evolution to Facilitate the Rapid and Efficient Discovery of Drug Lead by Wu, Fengxu, Zhuo, Linsheng, Wang, Fan, Huang, Wei, Hao, Gefei, Yang, Guangfu

“…Motivated by the growing demand for reducing the chemical optimization burden of H2L, we developed auto in silico ligand directing evolution…”
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Natural product evodiamine-inspired medicinal chemistry: Anticancer activity, structural optimization and structure-activity relationship by Wang, Zhen, Xiong, Yongxia, Peng, Ying, Zhang, Xi, Li, Shuang, Peng, Yan, Peng, Xue, Zhuo, Linsheng, Jiang, Weifan

“…It is a well-known phenomenon that natural products can serve as powerful drug leads to generate new molecular entities with novel therapeutic utility…”
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Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy by Zhang, Honghua, Peng, Yan, Zhuo, Linsheng, Wang, Yuying, Zeng, Guo, Wang, Shuzhi, Long, Lin, Li, Xuelin, Wang, Zhen

“…Due to the hugely important roles of neurotransmitter acetylcholine (ACh) and amyloid-β (Aβ) in the pathogenesis of Alzheimer's disease (AD), the development…”
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Discovery of 7-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridine derivatives as potent inhibitors of rearranged during transfection (RET) and RET solvent-front mutants for overcoming selpercatinib resistance by Wu, Junbo, Mo, Hanxuan, An, Zhigang, Tang, Zishu, Deng, Xinyu, Zhou, Huifang, Gong, Yi, Zheng, Chenggong, Zhuo, Linsheng, Tan, Shuguang

“…Rearranged during transfection kinase (RET) inhibition has been considered a promising therapeutic approach for treatment of a variety of cancers. However, the…”
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Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2 by Xu, Hongchuang, Wang, Minshu, Wu, Fengxu, Zhuo, Linsheng, Huang, Wei, She, Nengfang

“…[Display omitted] •N-substituted 1,6-naphthyridinones was identified as new MET inhibitor.•Lead compound 4r displayed promising selectivity against…”
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Structure-activity relationship study of 1,6-naphthyridinone derivatives as selective type II AXL inhibitors with potent antitumor efficacy by Zhuo, Linsheng, Guo, Mengqin, Zhang, Siyi, Wu, Junbo, Wang, Mingshu, Shen, Yang, Peng, Xue, Wang, Zhen, Jiang, Weifan, Huang, Wei

“…The role of AXL in various oncogenic processes has made it an attractive target for cancer therapy. Currently, kinase selectivity profiles, especially…”
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Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future by Li, Junfang, Wang, Xiaodong, Zhang, Honghua, Hu, Xiaoling, Peng, Xue, Jiang, Weifan, Zhuo, Linsheng, Peng, Yan, Zeng, Guo, Wang, Zhen

“…Fenamates as classical nonsteroidal anti-inflammatory agents are widely used for relieving pain. Preclinical studies and epidemiological data highlight their…”
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Discovery of carbamate-based salicylic acid derivatives as novel cholinesterase inhibitor by Wang, Yuying, Long, Lin, Yu, Quanwei, Zhang, Honghua, Li, Xuelin, Zhuo, Linsheng, Wang, Shuzhi, Wang, Zhen

“…•20 novel salicylic acid carbamate derivatives were synthesized for the systematical structure-activity relationship studies.•Compounds 3l and 3t are…”
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N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents by Deng, Jiedan, Long, Lin, Peng, Xue, Jiang, Weifan, Peng, Ying, Zhang, Xi, Zhao, Yuting, Tian, Ying, Wang, Zhen, Zhuo, Linsheng

“…Gastrointestinal tumor is an important factor threatening human health. Natural product-based drug discovery is a popular paradigm for expanding the chemical…”
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Design, synthesis, and biological evaluation of 1-styrenyl isoquinoline derivatives for anti-hepatocellular carcinoma activity and effect on mitochondria by Wang, Yuqing, Long, Lin, Zhuo, Linsheng, Zhang, Honghua, Luo, Tian, Deng, Jiedan, Wang, Yuying, Li, Zhao, Wang, Zhen, Peng, Xue

“…In this study, 18 derivatives of 1-styrene-isoquinoline were designed and synthesized from resveratrol and isoquinoline. The IC50 of compound 1c against Huh7…”
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Design, synthesis and biological evaluation of N-salicyloyl tryptamine derivatives as multifunctional neuroprotectants for the treatment of ischemic stroke by Wu, Genping, Li, Bo, Wei, Xiuzhen, Chen, Yaxin, Zhao, Yuting, Peng, Yan, Su, Jianhui, Hu, Zecheng, Zhuo, Linsheng, Tian, Ying, Wang, Zhen, Peng, Xue

“…Ischemic stroke (IS) is a disease of high death and disability worldwide with few medications in clinical treatment. Neuroinflammation and oxidative stress are…”
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Identification of a novel 10-hydroxyevodiamine prodrug as a potent topoisomerase inhibitor with improved aqueous solubility for treatment of hepatocellular carcinoma by Wei, Xiuzhen, Zhang, Xi, Peng, Yan, Wu, Junbo, Mo, Hanxuan, An, Zhigang, Deng, Xinyu, Peng, Ying, Liu, Linyi, Jiang, Weifan, Chen, Jinjin, Hu, Zecheng, Wang, Zhen, Zhuo, Linsheng

“…Natural product evodiamine (Evo) and its synthetic derivatives represent an attractive dual Topo 1/2 inhibitors with broad-spectrum antitumor efficacy…”
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Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer by Long, Lin, Xu, Jiachi, Qi, Xiaowen, Pen, Yan, Wang, Chengkun, Jiang, Weifan, Peng, Xue, Hu, Zecheng, Yi, Wenjun, Xie, Liming, Lei, Xiaoyong, Wang, Zhen, Zhuo, Linsheng

“…The deficiency in available targeted agents and frequency of chemoresistance are primary challenges in clinical management of triple-negative breast cancer…”
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Exploring the Therapeutic Effects of Multifunctional N‑Salicylic Acid Tryptamine Derivative against Parkinson’s Disease by Li, Xuelin, Wang, Shuzhi, Duan, Shan, Long, Lin, Zhuo, Linsheng, Peng, Yan, Xiong, Yongxia, Li, Shuang, Peng, Xue, Yan, Yiguo, Wang, Zhen, Jiang, Weifan

“…Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Neuroinflammation and oxidative stress play an important role in the…”
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Design, synthesis and evaluation of highly selective pyridone-based class II MET inhibitors by She, Nengfang, Zhuo, Linsheng, Jiang, Wen, Zhu, Xiaolei, Wang, Jia, Ming, Zhihui, Zhao, Xinge, Cong, Xin, Huang, Wei

“…The high incidence of MET oncogene activation in human malignancies has prompted researchers to develop MET inhibitors. As part of our efforts to developing…”
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