Search Results - "Zhulyn, Olena"

Pervasive translational regulation of the cell signalling circuitry underlies mammalian development by Fujii, Kotaro, Shi, Zhen, Zhulyn, Olena, Denans, Nicolas, Barna, Maria

“…The degree and dynamics of translational control during mammalian development remain poorly understood. Here we monitored translation of the mammalian genome…”
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Author Correction: Optogenetic manipulation of cellular communication using engineered myosin motors by Zhang, Zijian, Denans, Nicolas, Liu, Yingfei, Zhulyn, Olena, Rosenblatt, Hannah D., Wernig, Marius, Barna, Maria

“…A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00675-0…”
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Author Correction: Optogenetic manipulation of cellular communication using engineered myosin motors by Zhang, Zijian, Denans, Nicolas, Liu, Yingfei, Zhulyn, Olena, Rosenblatt, Hannah D., Wernig, Marius, Barna, Maria

“…A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00650-9…”
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Sufu and Kif7 in limb patterning and development by Zhulyn, Olena, Hui, Chi‐Chung

“…Background: The vertebrate digit pattern is defined by the morphogen Sonic hedgehog (Shh), which controls the activity of Gli transcription factors. Gli1, 2…”
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A Switch from Low to High Shh Activity Regulates Establishment of Limb Progenitors and Signaling Centers by Zhulyn, Olena, Li, Danyi, Deimling, Steven, Vakili, Niki Alizadeh, Mo, Rong, Puviindran, Vijitha, Chen, Miao-Hsueh, Chuang, Pao-Tien, Hopyan, Sevan, Hui, Chi-chung

“…The patterning and growth of the embryonic vertebrate limb is dependent on Sonic hedgehog (Shh), a morphogen that regulates the activity of Gli transcription…”
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T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor by Makino, Shigeru, Zhulyn, Olena, Mo, Rong, Puviindran, Vijitha, Zhang, Xiaoyun, Murata, Takuya, Fukumura, Ryutaro, Ishitsuka, Yuichi, Kotaki, Hayato, Matsumaru, Daisuke, Ishii, Shunsuke, Hui, Chi-Chung, Gondo, Yoichi

“…Hedgehog signaling is primarily transduced by two transcription factors: Gli2, which mainly acts as a full-length activator, and Gli3, which tends to be…”
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Salamanders' regenerative potential might be driven by a specific protein variant

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Optogenetic manipulation of cellular communication using engineered myosin motors by Zhang, Zijian, Denans, Nicolas, Liu, Yingfei, Zhulyn, Olena, Rosenblatt, Hannah D., Wernig, Marius, Barna, Maria

“…Cells achieve highly efficient and accurate communication through cellular projections such as neurites and filopodia, yet there is a lack of genetically…”
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Evolutionarily divergent mTOR remodels translatome for tissue regeneration by Zhulyn, Olena, Rosenblatt, Hannah D., Shokat, Leila, Dai, Shizhong, Kuzuoglu-Öztürk, Duygu, Zhang, Zijian, Ruggero, Davide, Shokat, Kevan M., Barna, Maria

“…An outstanding mystery in biology is why some species, such as the axolotl, can regenerate tissues whereas mammals cannot 1 . Here, we demonstrate that rapid…”
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Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development by Zhulyn, Olena, Nieuwenhuis, Erica, Liu, Yulu Cherry, Angers, Stephane, Hui, Chi-chung

“…Ptch1 and Ptch2 are highly conserved vertebrate homologs of Drosophila ptc, the receptor of the Hedgehog (Hh) signaling pathway. The vertebrate Ptch1 gene…”
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A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies by Tiu, Gerald C., Kerr, Craig H., Forester, Craig M., Krishnarao, Pallavi S., Rosenblatt, Hannah D., Raj, Nitin, Lantz, Travis C., Zhulyn, Olena, Bowen, Margot E., Shokat, Leila, Attardi, Laura D., Ruggero, Davide, Barna, Maria

“…In ribosomopathies, perturbed expression of ribosome components leads to tissue-specific phenotypes. What accounts for such tissue-selective manifestations as…”
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Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c by Fujii, Kotaro, Zhulyn, Olena, Byeon, Gun Woo, Genuth, Naomi R, Kerr, Craig H, Walsh, Erin M, Barna, Maria

“…Although gene expression is tightly regulated during embryonic development, the impact of translational control has received less experimental attention. Here,…”
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