Non-Coding RNAs Involved in the Regulation of Signaling Pathways as Possible Markers of Non-Alcoholic Fatty Liver Disease Progression

Non-Coding RNAs Involved in the Regulation of Signaling Pathways as Possible Markers of Non-Alcoholic Fatty Liver Disease Progression

The current understanding of the role of non-coding RNAs in the regulation of signaling pathways that control lipid accumulation and the development of inflammation in non-alcoholic fatty liver disease (NAFLD) is outlined. The contribution of peroxisome proliferator-activated receptors (PPARs) to ch...

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Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences Vol. 51; no. 5; pp. 1271 - 1290
Main Authors: Topchieva, L. V., Kurbatova, I. V., Dudanova, O. P., Vasilyeva, A. V., Zhulay, G. A.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-10-2024
Springer Nature B.V
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell activation
Cell Biology
Ecology
Fatty liver
Genetics
Hepatocytes
Life Sciences
Lipid metabolism
Liver diseases
miRNA
NF-κB protein
Non-coding RNA
Peroxisome proliferator-activated receptors
Signal transduction
Stat3 protein
Stellate cells
Zoology
non-coding RNAs
non-alcoholic fatty liver disease
signaling pathways
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Summary:The current understanding of the role of non-coding RNAs in the regulation of signaling pathways that control lipid accumulation and the development of inflammation in non-alcoholic fatty liver disease (NAFLD) is outlined. The contribution of peroxisome proliferator-activated receptors (PPARs) to changes in lipid metabolism and the formation of lipotoxicity as trigger mechanisms of NAFLD is considered. The role of TGFβ, TNFα/NF-κb, IL-6/JAK/STAT3 signaling pathways in the activation of stellate cells, liver fibrogenesis and the progression of NAFLD has been demonstrated. Analysis of literature data has revealed a number of microRNAs and long non-coding RNAs (lncRNAs) presumably associated with the regulation of these signaling pathways in this disease. They may probably have prognostic significance for differentiating clinical forms and severity of NAFLD.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359024607742