Search Results - "Zhuge, Zhengbing"

AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis by Cordero-Herrera, Isabel, Kozyra, Mikael, Zhuge, Zhengbing, Haworth, Sarah McCann, Moretti, Chiara, Peleli, Maria, Caldeira-Dias, Mayara, Jahandideh, Arghavan, Huirong, Han, de Campos Cruz, Josiane, Kleschyov, Andrei L., Montenegro, Marcelo F., Ingelman-Sundberg, Magnus, Weitzberg, Eddie, Lundberg, Jon O., Carlstrom, Mattias

“…Advanced age and unhealthy dietary habits contribute to the increasing incidence of obesity and type 2 diabetes. These metabolic disorders, which are often…”
Get full text

Blood Pressure–Lowering Effect of Orally Ingested Nitrite Is Abolished by a Proton Pump Inhibitor by Montenegro, Marcelo F, Sundqvist, Michaela L, Larsen, Filip J, Zhuge, Zhengbing, Carlström, Mattias, Weitzberg, Eddie, Lundberg, Jon O

“…Inorganic nitrate and nitrite from dietary and endogenous sources are metabolized to NO and other bioactive nitrogen oxides that affect blood pressure. The…”
Get full text

Red blood cells from endothelial nitric oxide synthase-deficient mice induce vascular dysfunction involving oxidative stress and endothelial arginase I by Zhuge, Zhengbing, McCann Haworth, Sarah, Nihlén, Carina, Carvalho, Lucas Rannier R.A., Heuser, Sophia K., Kleschyov, Andrei L., Nasiell, Josefine, Cortese-Krott, Miriam M., Weitzberg, Eddie, Lundberg, Jon O., Carlström, Mattias

“…Nitric oxide bioactivity (NO) from endothelial NO synthase (eNOS) importantly contributes to the maintenance of vascular homeostasis, and reduced eNOS activity…”
Get full text

Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress by Yang, Ting, Zhang, Xing-Mei, Tarnawski, Laura, Peleli, Maria, Zhuge, Zhengbing, Terrando, Niccolo, Harris, Robert A., Olofsson, Peder S., Larsson, Erik, Persson, A. Erik G., Lundberg, Jon O., Weitzberg, Eddie, Carlstrom, Mattias

“…Ischemia-reperfusion (IR) injury involves complex pathological processes in which reduction of nitric oxide (NO) bioavailability is suggested as a key factor…”
Get full text

Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway by Li, Xuechen, Zhuge, Zhengbing, Carvalho, Lucas Rannier R.A., Braga, Valdir A., Lucena, Ricardo Barbosa, Li, Shuijie, Schiffer, Tomas A., Han, Huirong, Weitzberg, Eddie, Lundberg, Jon O., Carlström, Mattias

“…Renal fibrosis, associated with oxidative stress and nitric oxide (NO) deficiency, contributes to the development of chronic kidney disease and renal failure…”
Get full text

Inhibitory Effects of Hydroxysafflor Yellow A on the Formation of Advanced Glycation End Products in Vitro by Ni, Zhenzhen, Zhuge, Zhengbing, Li, Wenlu, Xu, Huimin, Zhang, Zhongmiao, Dai, Haibin

“…To investigate the inhibitory effects of hydroxysafflor yellow A (HSYA) on the protein glycation in vitro. Using bovine serum albumin (BSA)-glucose assay,…”
Get full text

Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney by Zhang, Gensheng, Han, Huirong, Zhuge, Zhengbing, Dong, Fang, Jiang, Shan, Wang, Wenwen, Guimarães, Drielle D., Schiffer, Tomas A., Lai, En Yin, Ribeiro Antonino Carvalho, Lucas Rannier, Lucena, Ricardo Barbosa, Braga, Valdir A., Weitzberg, Eddie, Lundberg, Jon O., Carlstrom, Mattias

“…Renal ischemia-reperfusion (IR) injury is a common cause of acute kidney injury (AKI), which is associated with oxidative stress and reduced nitric oxide (NO)…”
Get full text

Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity by Peleli, Maria, Flacker, Peter, Zhuge, Zhengbing, Gomez, Cristina, Wheelock, Craig E., Persson, A. Erik G., Carlstrom, Mattias

“…Oxidative stress is considered a central pathophysiological event in cardiovascular disease, including hypertension. Early age reduction in renal mass is…”
Get full text

Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice by Zhang, Suping, Huang, Qian, Wang, Qiaoling, Wang, Qin, Cao, Xiaoyun, Zhao, Liang, Xu, Nan, Zhuge, Zhengbing, Mao, Jianhua, Fu, Xiaodong, Liu, Ruisheng, Wilcox, Christopher S., Patzak, Andreas, Li, Lingli, Lai, En Yin

“…Background/Aims: Canonical Wnt signaling is involved in oxidative stress, vasculopathy and diabetes mellitus but its role in diabetic renal microvascular…”
Get full text

Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt–Induced Hypertension by Yang, Ting, Zollbrecht, Christa, Winerdal, Malin E., Zhuge, Zhengbing, Zhang, Xing‐Mei, Terrando, Niccolo, Checa, Antonio, Sällström, Johan, Wheelock, Craig E., Winqvist, Ola, Harris, Robert A., Larsson, Erik, Persson, A. Erik G., Fredholm, Bertil B., Carlström, Mattias

“…Background Early‐life reduction in nephron number (uninephrectomy [UNX]) and chronic high salt (HS) intake increase the risk of hypertension and chronic kidney…”
Get full text

The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats by Paulo, Luciano L., Cruz, Josiane Campos, Zhuge, Zhengbing, Carvalho-Galvão, Alynne, Brandão, Maria C.R., Diniz, Thiago F., Haworth, Sarah McCann, Athayde-Filho, Petrônio F., Lemos, Virginia S., Lundberg, Jon O., Montenegro, Marcelo F., Braga, Valdir A., Carlström, Mattias

“…Development and progression of cardiovascular diseases, including hypertension, are often associated with impaired nitric oxide synthase (NOS) function and…”
Get full text

Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation by Zhuge, Zhengbing, Paulo, Luciano L., Jahandideh, Arghavan, Brandão, Maria C.R., Athayde-Filho, Petrônio F., Lundberg, Jon O., Braga, Valdir A., Carlström, Mattias, Montenegro, Marcelo F.

“…In this report, we describe the synthesis and characterization of 1,3-bis(hexyloxy)propan-2-yl nitrate (NDHP), a novel organic mono nitrate. Using purified…”
Get full text

Nitric Oxide in Cardiovascular and Renal Disease: Role of Organic Nitrates, Inorganic Nitrate and Red Blood Cells by Zhuge, Zhengbing

“…RATIONALE: Cardiovascular and renal disorders are major health problems, which are often co-existing. Mechanistically, these conditions can be attributed to…”
Get full text

Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring by Manti, Maria, Fornes, Romina, Pironti, Gianluigi, McCann Haworth, Sarah, Zhengbing, Zhuge, Benrick, Anna, Carlström, Mattias, Andersson, Daniel, Stener-Victorin, Elisabet

“…Abstract Aims Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is suggested to increase the risk for cardiovascular disease. How PCOS may lead…”
Get full text

Red blood cells from patients with pre-eclampsia induce endothelial dysfunction by McCann Haworth, Sarah M., Zhuge, Zhengbing, Nihlén, Carina, Von Rosen, Matilda Fornell, Weitzberg, Eddie, Lundberg, Jon O., Krmar, Rafael T., Nasiell, Josefine, Carlström, Mattias

Get full text

Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell by Sun, Chiao-Wang, Yang, Jiangning, Kleschyov, Andrei L, Zhuge, Zhengbing, Carlström, Mattias, Pernow, John, Wajih, Nadeem, Isbell, T Scott, Oh, Joo-Yeun, Cabrales, Pedro, Tsai, Amy G, Townes, Tim, Kim-Shapiro, Daniel B, Patel, Rakesh P, Lundberg, Jon O

“…BACKGROUND:Nitrosation of a conserved cysteine residue at position 93 in the hemoglobin β chain (β93C) to form S-nitroso (SNO) hemoglobin (Hb) is claimed to be…”
Get full text

NO-ferroheme is a signaling entity in the vasculature by Kleschyov, Andrei L., Zhuge, Zhengbing, Schiffer, Tomas A., Guimarães, Drielle D., Zhang, Gensheng, Montenegro, Marcelo F., Tesse, Angela, Weitzberg, Eddie, Carlström, Mattias, Lundberg, Jon O.

“…Despite wide appreciation of the biological role of nitric oxide (NO) synthase (NOS) signaling, questions remain about the chemical nature of NOS-derived…”
Get full text

Red blood cells from patients with pre-eclampsia induce endothelial dysfunction by McCann Haworth, Sarah M., Zhuge, Zhengbing, Nihlén, Carina, Von Rosen, Matilda Fornell, Weitzberg, Eddie, Lundberg, Jon O., Krmar, Rafael T., Nasiell, Josefine, Carlström, Mattias

“…Pre-eclampsia is a multisystem disorder associated with systemic vascular dysfunction and decreased nitric oxide (NO) bioactivity. Arginase competes with NO…”
Get full text

Cholinergic regulation of vascular endothelial function by human ChAT + T cells by Tarnawski, Laura, Shavva, Vladimir S, Kort, Eric J, Zhuge, Zhengbing, Nilsson, Ingrid, Gallina, Alessandro L, Martínez-Enguita, David, Heller Sahlgren, Benjamin, Weiland, Matthew, Caravaca, April S, Schmidt, Staffan, Chen, Ping, Abbas, Katarina, Wang, Fu-Hua, Ahmed, Osman, Eberhardson, Michael, Färnert, Anna, Weitzberg, Eddie, Gustafsson, Mika, Kehr, Jan, Malin, Stephen G, Hult, Henrik, Carlström, Mattias, Jovinge, Stefan, Olofsson, Peder S

“…Endothelial dysfunction and impaired vasodilation are linked with adverse cardiovascular events. T lymphocytes expressing choline acetyltransferase (ChAT), the…”
Get full text

The obligatory role of host microbiota in bioactivation of dietary nitrate by Moretti, Chiara, Zhuge, Zhengbing, Zhang, Gensheng, Haworth, Sarah McCann, Paulo, Luciano L., Guimarães, Drielle D., Cruz, Josiane C., Montenegro, Marcelo F., Cordero-Herrera, Isabel, Braga, Valdir A., Weitzberg, Eddie, Carlström, Mattias, Lundberg, Jon O.

“…Nitric oxide (NO) is a key signalling molecule in the regulation of cardiometabolic function and impaired bioactivity is considered to play an important role…”
Get full text