Search Results - "Zhuang, Rangxiao"

Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases by Xi, Jianjun, Zhuang, Rangxiao, Kong, Limin, He, Ruoyu, Zhu, Huajian, Zhang, Jiankang

“…The immunoproteasome, a specialized form of proteasome, is mainly expressed in lymphocytes and monocytes of jawed vertebrates and responsible for the…”
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pH-Responsive and Liver-targeting Drug Delivery System for Combination Delivery of Artesunate with Arsenic Trioxide Prodrug against Hepatocellular Carcinoma by Pan, Xuwang, Huang, Jinsong, Liu, Shourong, Shao, Yidan, Xi, Jianjun, He, Ruoyu, Shi, Tingting, Rangxiao, Zhuang, Yu, Wenying

“…Arsenic trioxide (ATO) exerts therapeutic effects on various solid tumors, and artesunate (ART) synergizes with antitumor drugs. We herein combined ART and an…”
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Protective effect of apigenin magnesium complex on H2O2-induced oxidative stress and inflammatory responses in rat hepatic stellate cells by Pan, Xuwang, Shao, Yidan, Wang, Fugen, Cai, Zhaobin, Liu, Shourong, Xi, Jianjun, He, Ruoyu, Zhao, Yanmei, Zhuang, Rangxiao

“…Apigenin displays antioxidant and anti-inflammatory effects. However, effects of apigenin magnesium (AM) complex on these aspects remain unknown. This study…”
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Activated carbon N-acetylcysteine microcapsule protects against nonalcoholic fatty liver disease in young rats via activating telomerase and inhibiting apoptosis by Shi, Tingting, Yang, Xingxin, Zhou, Hongping, Xi, Jianjun, Sun, Jingjing, Ke, Yunling, Zhang, Jiankang, Shao, Yidan, Jiang, Xiaojie, Pan, Xuwang, Liu, Shourong, Zhuang, Rangxiao

“…Non-alcoholic fatty liver disease (NAFLD) is becoming one of the world's most common chronic liver diseases in childhood, yet no therapy is available that has…”
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Regulation of Mitochondrial Function by Natural Products for the Treatment of Metabolic Associated Fatty Liver Disease by Shi, Tingting, Yu, Liping, Zhuang, Rangxiao, Xi, Jianjun, He, Ruoyu, Shao, Yidan, Huang, Jinsong, Liu, Shourong, Yang, Xingxin

“…Metabolic associated fatty liver disease (MAFLD) is a multifactorial systemic disorder that occurs in the absence of excessive alcohol consumption. The disease…”
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Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing dihydroquinoxalinone as novel EGFRL858R/T790M kinase inhibitors against non-small-cell lung cancer by Fu, Liping, Cao, Yu, Chen, Jingbai, He, Ruoyu, Zhao, Yanmei, Zhao, Yaping, Xi, Jianjun, Zhuang, Rangxiao, Tian, Chongmei

“…The clinical responses to the EGFR kinase inhibitors in non-small cell lung cancer (NSCLC) patients are always followed by drug-resistance mutations, including…”
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Protective effects of N-acetylcysteine on cisplatin-induced oxidative stress and DNA damage in HepG2 cells by WANG, FUGEN, LIU, SHOURONG, SHEN, YIQIN, ZHUANG, RANGXIAO, XI, JIANJUN, FANG, HONGYING, PAN, XUWAN, SUN, JINGJING, CAI, ZHAOBIN

“…Hepatocyte injury is a common pathological effect of cisplatin (CDDP) in various solid tumor therapies. Thus, strategies for minimizing CDDP toxicity are of…”
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Recent progress and applications of small molecule inhibitors of Keap1-Nrf2 axis for neurodegenerative diseases by Wang, Jing, Cao, Yu, Lu, Yang, Zhu, Huajian, Zhang, Jiankang, Che, Jinxin, Zhuang, Rangxiao, Shao, Jiaan

“…The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway serves as a crucial regulator against oxidative…”
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Design, synthesis, and anticancer evaluation of alkynylated pyrrole derivatives by Wei, Hegeng, Cao, Yu, Zhao, Chungang, Shao, Zhanying, Huo, Xiaoli, Pan, Jinming, Zhuang, Rangxiao

“…A series of alkynylated pyrrole derivatives were meticulously designed, drawing inspiration from the structure of 3‐alkynylpyrrole‐2,4‐dicarboxylates, which…”
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Recent advances and future perspectives of noncompetitive proteasome inhibitors by Zeng, Gongruixue, Yu, Qian, Zhuang, Rangxiao, Zhu, Huajian, Shao, Jiaan, Xi, Jianjun, Zhang, Jiankang

“…[Display omitted] •An overview of the structure and functions of proteasome.•Elucidate the mechanism of action of noncompetitive proteasome inhibitors and…”
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Preparation, evaluation, and in vitro cytotoxicity studies of artesunate-loaded glycyrrhetinic acid decorated PEG-PLGA nanoparticles by Pan, Xuwang, Liu, Shourong, Ju, Liping, Xi, Jianjun, He, Ruoyu, Zhao, Yanmei, Zhuang, Rangxiao, Huang, Jinsong

“…The objective of this study was to prepare the liver targeting drug delivery system (TDDS) of artesunate (ART)-loaded polyethylene glycol…”
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Synthesis of isoquinolone via rhodium(III)-catalyzed C-H activation with 1,4,2-dioxazol-5-ones as oxidizing directing group by Zhu, Huajian, Zhuang, Rangxiao, Zheng, Wenya, Fu, Liping, Zhao, Yuanke, Tu, Luping, Chai, Yitao, Zeng, Linghui, Zhang, Chong, Zhang, Jiankang

“…An efficient rhodium-catalyzed direct C-H activation for the synthesis of isoquinolone with 1,4,2-dioxazol-5-ones as oxidizing directing groups have been…”
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Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins by Yu, Qian, Wang, Zheng, Tu, Yutong, Cao, Yu, Zhu, Huajian, Shao, Jiaan, Zhuang, Rangxiao, Zhou, Yubo, Zhang, Jiankang

“…[Display omitted] Intrinsically disordered proteins (IDPs) are characterized by their inability to adopt well-defined tertiary structures under physiological…”
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Immunoproteasome-selective inhibitors: the future of autoimmune diseases? by Zhang, Chong, Zhu, Huajian, Shao, Jiaan, He, Ruoyu, Xi, Jianjun, Zhuang, Rangxiao, Zhang, Jiankang

“…For immunoproteasome β5i, configuration alteration at the position of Met45 as well as mutation of Val31 of constitutive proteasome β5c into Met31 result in a…”
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Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors by Zhao, Yanmei, Xu, Lei, Zhang, Jiankang, Zhang, Mengmeng, Lu, Jingyi, He, Ruoyu, Xi, Jianjun, Zhuang, Rangxiao, Li, Jia, Zhou, Yubo

“…[Display omitted] A series of non-covalent piperidine-containing peptidyl derivatives with various substituents at side chains of different residues were…”
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Morroniside Delays NAFLD Progression in Fructose-Fed Mice by Normalizing Lipid Metabolism and Inhibiting the Inflammatory Response by Tong, Qiao, Xi, Jianjun, Cao, Yu, He, Ruoyu, Zhao, Yanmei, Shao, Yidan, Pan, Xuwang, Huang, Jinsong, Chen, Yongping, Zhuang, Rangxiao

“…Chronic fructose consumption is becoming one leading risk factor for NAFLD due to its hazard on cellular lipid metabolism, which plays an essential role in the…”
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Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors by Zhao, Yanmei, Zhang, Jiankang, Zhuang, Rangxiao, He, Ruoyu, Xi, Jianjun, Pan, Xuwang, Shao, Yidan, Pan, Jinming, Sun, Jingjing, Cai, Zhaobin, Liu, Shourong, Huang, Weiwei, Lv, Xiaoqing

“…[Display omitted] In this study, a series of novel pyridine and pyrimidine-containing derivatives were designed, synthesized and biologically evaluated for…”
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Protective effect of apigenin magnesium complex on H 2 O 2 -induced oxidative stress and inflammatory responses in rat hepatic stellate cells by Pan, Xuwang, Shao, Yidan, Wang, Fugen, Cai, Zhaobin, Liu, Shourong, Xi, Jianjun, He, Ruoyu, Zhao, Yanmei, Zhuang, Rangxiao

“…Apigenin displays antioxidant and anti-inflammatory effects. However, effects of apigenin magnesium (AM) complex on these aspects remain unknown. This study…”
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Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors by Zhang, Jiankang, Gao, Lixin, Xi, Jianjun, Sheng, Li, Zhao, Yanmei, Xu, Lei, Shao, Yidan, Liu, Shourong, Zhuang, Rangxiao, Zhou, Yubo, Li, Jia

“…[Display omitted] A series of novel non-covalent piperidine-containing dipeptidyl derivatives were designed, synthesized and evaluated as proteasome…”
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Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer by Cao, Yu, Zhu, Huajian, He, Ruoyu, Kong, Limin, Shao, Jiaan, Zhuang, Rangxiao, Xi, Jianjun, Zhang, Jiankang

“…Proteasome is vital for intracellular protein homeostasis as it eliminates misfolded and damaged protein. Inhibition of proteasome has been validated as a…”
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