Search Results - "ZhuGe, Qichuan"

Tissue Plasminogen Activator-Porous Magnetic Microrods for Targeted Thrombolytic Therapy after Ischemic Stroke by Hu, Jiangnan, Huang, Shengwei, Zhu, Lu, Huang, Weijie, Zhao, Yiping, Jin, Kunlin, ZhuGe, Qichuan

“…Tissue plasminogen activator (tPA) is the only FDA approved thrombolytic drug for acute ischemic stroke but concerns regarding its limitations remain. Here, we…”
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Acceleration of Tissue Plasminogen Activator-Mediated Thrombolysis by Magnetically Powered Nanomotors by Cheng, Rui, Huang, Weijie, Huang, Lijie, Yang, Bo, Mao, Leidong, Jin, Kunlin, ZhuGe, Qichuan, Zhao, Yiping

“…Dose control and effectiveness promotion of tissue plasminogen activator (t-PA) for thrombolysis are vitally important to alleviate serious side effects such…”
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Melatonin Enhances the Therapeutic Effect of Plasma Exosomes Against Cerebral Ischemia-Induced Pyroptosis Through the TLR4/NF-κB Pathway by Wang, Kankai, Ru, Junnan, Zhang, Hengli, Chen, Jiayu, Lin, Xiao, Lin, Zhongxiao, Wen, Min, Huang, Lijie, Ni, Haoqi, Zhuge, Qichuan, Yang, Su

“…Ischemic stroke-induced inflammation and inflammasome-dependent pyroptotic neural death cause serious neurological injury. Nano-sized plasma exosomes have…”
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Regulating Lars2 in mitochondria: A potential Alzheimer's therapy by inhibiting tau phosphorylation by Qian, Wenqi, Yuan, Lin, Zhuge, Weishan, Gu, Liuqing, Chen, Yutian, Zhuge, Qichuan, Ni, Haoqi, Lv, Xinhuang

“…Driven by the scarcity of effective treatment options in clinical settings, the present study aimed to identify a new potential target for Alzheimer's disease…”
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Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia by Wang, Kankai, Sun, Zhezhe, Ru, Junnan, Wang, Simin, Huang, Lijie, Ruan, Linhui, Lin, Xiao, Jin, Kunlin, Zhuge, Qichuan, Yang, Su

“…Ischemia/reperfusion (I/R) injury is a significant cause of mortality and long-term disability worldwide. Recent evidence has proved that pyroptosis, a novel…”
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Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging by Yu, Mengdi, Zhang, Hongxia, Wang, Brian, Zhang, Yinuo, Zheng, Xiaoying, Shao, Bei, Zhuge, Qichuan, Jin, Kunlin

“…Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such…”
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Development and performance assessment of novel machine learning models for predicting postoperative pneumonia in aneurysmal subarachnoid hemorrhage patients: external validation in MIMIC-IV by Li, Xinbo, Zhang, Chengwei, Wang, Jiale, Ye, Chengxing, Zhu, Jiaqian, Zhuge, Qichuan

“…Postoperative pneumonia (POP) is one of the primary complications after aneurysmal subarachnoid hemorrhage (aSAH) and is associated with postoperative…”
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Metformin, Rapamycin, or Nicotinamide Mononucleotide Pretreatment Attenuate Cognitive Impairment After Cerebral Hypoperfusion by Inhibiting Microglial Phagocytosis by Yu, Mengdi, Zheng, Xiaoying, Cheng, Fangyu, Shao, Bei, Zhuge, Qichuan, Jin, Kunlin

“…Vascular cognitive impairment (VCI) is the second leading form of dementia after Alzheimer's disease (AD) plaguing the elder population. Despite the enormous…”
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Insulin Resistance Disrupts the Interaction Between AKT and the NMDA Receptor and the Inactivation of the CaMKIV/CREB Pathway in Minimal Hepatic Encephalopathy by Ding, Saidan, Zhuge, Weishan, Yang, Jianjing, Wen, Fangfang, Xu, Zhu, Wang, Xuebao, Zhuge, Qichuan

“…Hepatic cirrhosis-induced Minimal hepatic encephalopathy (MHE) has been characterized for cognitive dysfunction and central nervous system (CNS) insulin…”
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AC-YVAD-CMK Inhibits Pyroptosis and Improves Functional Outcome after Intracerebral Hemorrhage by Huang, Lijie, Zhuge, Qichuan, Xu, Zhu, Ni, Haoqi, He, Zibin, Pan, Sishi, Siaw-Debrah, Felix, Ye, Haotuo, Lin, Xiao, Jin, Kunlin

“…Intracerebral hemorrhage (ICH) refers to bleeding in the brain and is associated with the release of large amount of inflammasomes, and the activation of…”
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Synthetic minority over-sampling technique-enhanced machine learning models for predicting recurrence of postoperative chronic subdural hematoma by Ni, Zhihui, Zhu, Yehao, Qian, Yiwei, Li, Xinbo, Xing, Zhenqiu, Zhou, Yinan, Chen, Yu, Huang, Lijie, Yang, Jianjing, Zhuge, Qichuan

“…Chronic subdural hematoma (CSDH) is a neurological condition with high recurrence rates, primarily observed in the elderly population. Although several risk…”
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Development of a deep learning model for early gastric cancer diagnosis using preoperative computed tomography images by Gao, Zhihong, Yu, Zhuo, Zhang, Xiang, Chen, Chun, Pan, Zhifang, Chen, Xiaodong, Lin, Weihong, Chen, Jun, Zhuge, Qichuan, Shen, Xian

“…Background Gastric cancer is a highly prevalent and fatal disease. Accurate differentiation between early gastric cancer (EGC) and advanced gastric cancer…”
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Oridonin prevents insulin resistance–mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy by Wen, Fangfang, Zhuge, Weishan, Wang, Jian, Lu, Xiaoai, You, Ruimin, Liu, Leping, Zhuge, Qichuan, Ding, Saidan

“…Minimal hepatic encephalopathy (MHE) was characterized for cognitive dysfunction. Insulin resistance (IR) has been identified to be correlated with the…”
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Elevated blood urea nitrogen is associated with recurrence of post-operative chronic subdural hematoma by Wang, Ning, Hu, Jiangnan, Oppong-Gyebi, Anthony, Zhu, Xuanhao, Li, Yihao, Yang, Jianjing, Ruan, Linhui, Zhuge, Qichuan, Ye, Sheng

“…Chronic subdural hematoma (CSDH) is fundamentally treatable with about a 2-31% recurrence rate. Recently, there has been renewed interest in the association…”
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Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury by Hu, Jiangnan, Chen, Lefu, Huang, Xujun, Wu, Ke, Ding, Saidan, Wang, Weikan, Wang, Brian, Smith, Charity, Ren, Changhong, Ni, Haoqi, ZhuGe, Qichuan, Yang, Jianjing

“…Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number…”
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Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models by Zhang, Ying, Xie, Xinyang, Hu, Jiangnan, Afreen, Kazi Sabrina, Zhang, Chun-Li, Zhuge, Qichuan, Yang, Jianjing

“…A reliable disease model is critical to the study of specific disease mechanisms as well as for the discovery and development of new drugs. Despite providing…”
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The Involvement of the Decrease of Astrocytic Wnt5a in the Cognitive Decline in Minimal Hepatic Encephalopathy by Ding, Saidan, Xu, Zhu, Yang, Jianjing, Liu, Leping, Huang, Xueli, Wang, Xuebao, Zhuge, Qichuan

“…Wnt signaling plays a key role in neuroprotection and synaptic plasticity. We speculate that the impairment of Wnt signaling may mediate astrocytic…”
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A Novel Richardson-Lucy Model with Dictionary Basis and Spatial Regularization for Isolating Isotropic Signals by Xu, Tiantian, Feng, Yuanjing, Wu, Ye, Zeng, Qingrun, Zhang, Jun, He, Jianzhong, Zhuge, Qichuan

“…Diffusion-weighted magnetic resonance imaging is a non-invasive imaging method that has been increasingly used in neuroscience imaging over the last decade…”
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NT3P75-2 gene-modified bone mesenchymal stem cells improve neurological function recovery in mouse TBI model by Wu, Ke, Huang, Dongdong, Zhu, Can, Kasanga, Ella A, Zhang, Ying, Yu, Enxing, Zhang, Hengli, Ni, Zhihui, Ye, Sheng, Zhang, Chunli, Hu, Jiangnan, Zhuge, Qichuan, Yang, Jianjing

“…Abstract Background The attainment of extensive neurological function recovery remains the key challenge for the treatment of traumatic brain injury (TBI)…”
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Recent Advances in Tissue plasminogen activator-based nanothrombolysis for ischemic stroke by Huang, Dongdong, Wu, Ke, Zhang, Ying, Ni, Zhihui, Zhu, Xiaohong, Zhu, Can, Yang, Jianjing, ZhuGe, Qichuan, Hu, Jiangnan

“…Stroke is an acute cerebrovascular disorder caused by sudden decrease or interruption of blood flow in brain arteries. Deficiency of timely and effective…”
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