Search Results - "Zhu, Yuelin J"

A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors by Petrini, Iacopo, Meltzer, Paul S, Kim, In-Kyu, Lucchi, Marco, Park, Kang-Seo, Fontanini, Gabriella, Gao, James, Zucali, Paolo A, Calabrese, Fiorella, Favaretto, Adolfo, Rea, Federico, Rodriguez-Canales, Jaime, Walker, Robert L, Pineda, Marbin, Zhu, Yuelin J, Lau, Christopher, Killian, Keith J, Bilke, Sven, Voeller, Donna, Dakshanamurthy, Sivanesan, Wang, Yisong, Giaccone, Giuseppe

“…Giuseppe Giaccone and colleagues identify a recurrent missense mutation in GTF2I in a high percentage of thymic epithelial tumors. The mutation occurs more…”
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Bromodomain and Extraterminal Protein Inhibitor JQ1 Suppresses Thyroid Tumor Growth in a Mouse Model by Zhu, Xuguang, Enomoto, Keisuke, Zhao, Li, Zhu, Yuelin J, Willingham, Mark C, Meltzer, Paul, Qi, Jun, Cheng, Sheue-Yann

“…New therapeutic approaches are needed for patients with thyroid cancer refractory to radioiodine treatment. An inhibitor of bromodomain and extraterminal…”
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Targeting MYC as a Therapeutic Intervention for Anaplastic Thyroid Cancer by Enomoto, Keisuke, Zhu, Xuguang, Park, Sunmi, Zhao, Li, Zhu, Yuelin J., Willingham, Mark C., Qi, Jun, Copland, John A., Meltzer, Paul, Cheng, Sheue-yann

“…Abstract Context: Recent studies showed that transcription of the MYC gene is driven by the interaction of bromodomain and extraterminal domain (BET) proteins…”
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Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer by Bilke, Sven, Schwentner, Raphaela, Yang, Fan, Kauer, Maximilian, Jug, Gunhild, Walker, Robert L, Davis, Sean, Zhu, Yuelin J, Pineda, Marbin, Meltzer, Paul S, Kovar, Heinrich

“…Deregulated E2F transcription factor activity occurs in the vast majority of human tumors and has been solidly implicated in disturbances of cell cycle…”
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Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background by Yin, Mianmian, Chung, Yang Jo, Lindsley, R. Coleman, Walker, Robert L., Zhu, Yuelin J., Ebert, Benjamin L., Meltzer, Paul S., Aplan, Peter D.

“…Approximately 10% of NUP98-PHF23 (NP23) mice develop an aggressive acute lymphoblastic leukemia of B-1 lymphocyte progenitor origin (pro-B1 ALL), accompanied…”
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Thymic precursor cells generate acute myeloid leukemia in NUP98-PHF23/NUP98-HOXD13 double transgenic mice by Kundu, Subhadip, Park, Eun Sil, Chung, Yang Jo, Walker, Robert L., Zhu, Yuelin J., Negi, Vijay, Meltzer, Paul S., Aplan, Peter D.

“…Transgenic mice that express either a NUP98–PHF23 (NP23) or NUP98-HOXD13 (NHD13) fusion in the hematopoietic compartment develop a wide spectrum of leukemias,…”
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The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway by Hao, Qinyu, Zong, Xinying, Sun, Qinyu, Lin, Yo-Chuen, Song, You Jin, Hashemikhabir, Seyedsasan, Hsu, Rosaline Yc, Kamran, Mohammad, Chaudhary, Ritu, Tripathi, Vidisha, Singh, Deepak Kumar, Chakraborty, Arindam, Li, Xiao Ling, Kim, Yoon Jung, Orjalo, Arturo V, Polycarpou-Schwarz, Maria, Moriarity, Branden S, Jenkins, Lisa M, Johansson, Hans E, Zhu, Yuelin J, Diederichs, Sven, Bagchi, Anindya, Kim, Tae Hoon, Janga, Sarath C, Lal, Ashish, Prasanth, Supriya G, Prasanth, Kannanganattu V

“…Cell cycle is a cellular process that is subject to stringent control. In contrast to the wealth of knowledge of proteins controlling the cell cycle, very…”
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Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy by KEMP, Clinton D, RAO, Mahadev, ZHU, Yuelin J, TAYLOR RIPLEY, R, MATHUR, Aarti, FANG LIU, MAOCHENG YANG, MELTZER, Paul A, MARQUEZ, Victor E, DE RIENZO, Assunta, BUENO, Raphael, SCHRUMP, David S, SICHUAN XI, INCHAUSTE, Suzanne, MANI, Haresh, FETSCH, Patricia, FILIE, Armando, MARY ZHANG, HONG, Julie A, WALKER, Robert L

“…Polycomb group (PcG) proteins are critical epigenetic mediators of stem cell pluripotency, which have been implicated in the pathogenesis of human cancers…”
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miR-23a impairs bone differentiation in osteosarcoma via down-regulation of GJA1 by Gindin, Yevgeniy, Jiang, Yuan, Francis, Princy, Walker, Robert L, Abaan, Ogan D, Zhu, Yuelin J, Meltzer, Paul S

“…Osteosarcoma is the most common type of bone cancer in children and adolescents. Impaired differentiation of osteoblast cells is a distinguishing feature of…”
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A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology by Trucco, Matteo M, Awad, Ola, Wilky, Breelyn A, Goldstein, Seth D, Huang, Ruili, Walker, Robert L, Shah, Preeti, Katuri, Varalakshmi, Gul, Naheed, Zhu, Yuelin J, McCarthy, Edward F, Paz-Priel, Ido, Meltzer, Paul S, Austin, Christopher P, Xia, Menghang, Loeb, David M

“…Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are…”
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Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways by Gough, Sheryl M., Goldberg, Liat, Pineda, Marbin, Walker, Robert L., Zhu, Yuelin J., Bilke, Sven, Chung, Yang Jo, Dufraine, Joseph, Kundu, Subhadip, Jacoby, Elad, Fry, Terry J., Fischer, Susanna, Panzer-Grümayer, Renate, Meltzer, Paul S., Aplan, Peter D.

“…B-1 and B-2 lymphocytes are derived from distinct developmental pathways and represent layered arms of the innate and adaptive immune systems, respectively. In…”
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Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma by Chaisaingmongkol, Jittiporn, Budhu, Anuradha, Dang, Hien, Rabibhadana, Siritida, Pupacdi, Benjarath, Kwon, So Mee, Forgues, Marshonna, Pomyen, Yotsawat, Bhudhisawasdi, Vajarabhongsa, Lertprasertsuke, Nirush, Chotirosniramit, Anon, Pairojkul, Chawalit, Auewarakul, Chirayu U., Sricharunrat, Thaniya, Phornphutkul, Kannika, Sangrajrang, Suleeporn, Cam, Maggie, He, Ping, Hewitt, Stephen M., Ylaya, Kris, Wu, Xiaolin, Andersen, Jesper B., Thorgeirsson, Snorri S., Waterfall, Joshua J., Zhu, Yuelin J., Walling, Jennifer, Stevenson, Holly S., Edelman, Daniel, Meltzer, Paul S., Loffredo, Christopher A., Hama, Natsuko, Shibata, Tatsuhiro, Wiltrout, Robert H., Harris, Curtis C., Mahidol, Chulabhorn, Ruchirawat, Mathuros, Wang, Xin W.

“…Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically disparate primary liver cancers with etiological and biological…”
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The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology by ABAAN, Ogan D, POLLEY, Eric C, HOLBECK, Susan L, SIMON, Richard M, DOROSHOW, James H, POMMIER, Yves, MELTZER, Paul S, DAVIS, Sean R, ZHU, Yuelin J, BILKE, Sven, WALKER, Robert L, PINEDA, Marbin, GINDIN, Yevgeniy, YUAN JIANG, REINHOLD, William C

“…The NCI-60 cell lines are the most frequently studied human tumor cell lines in cancer research. This panel has generated the most extensive cancer…”
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Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling by Grøntved, Lars, Waterfall, Joshua J., Kim, Dong Wook, Baek, Songjoon, Sung, Myong-Hee, Zhao, Li, Park, Jeong Won, Nielsen, Ronni, Walker, Robert L., Zhu, Yuelin J., Meltzer, Paul S., Hager, Gordon L., Cheng, Sheue-yann

“…A bimodal switch model is widely used to describe transcriptional regulation by the thyroid hormone receptor (TR). In this model, the unliganded TR forms…”
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NUP98::Nsd1 and FLT3-ITD collaborate to generate acute myeloid leukemia by Matsukawa, Toshihiro, Yin, Mianmian, Nigam, Nupur, Negi, Vijay, Li, Li, Small, Donald, Zhu, Yuelin J., Walker, Robert L., Meltzer, Paul S., Aplan, Peter D.

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Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis by Hirsch, Daniela, Wangsa, Darawalee, Zhu, Yuelin J, Hu, Yue, Edelman, Daniel C, Meltzer, Paul S, Heselmeyer-Haddad, Kerstin, Ott, Claudia, Kienle, Peter, Galata, Christian, Horisberger, Karoline, Ried, Thomas, Gaiser, Timo

“…Patients with inflammatory bowel diseases, that is, ulcerative colitis and Crohn's disease (CD), face an increased risk of developing colorectal cancer (CRC)…”
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The DNA Methyltransferase Inhibitor 5-Aza-4'-thio-2'-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development by Bertoli, Ryan M, Chung, Yang Jo, Difilippantonio, Michael J, Wokasch, Anthony, Marasco, Madison R B, Klimaszewski, Haley, Gammell, Susannah, Zhu, Yuelin J, Walker, Robert L, Cao, Dengchao, Khanna, Ajay, Walter, Matthew J, Doroshow, James H, Meltzer, Paul S, Aplan, Peter D

“…DNA methyltransferase inhibitors (DNMTi), most commonly cytidine analogs, are compounds that decrease 5'-cytosine methylation. DNMTi are used clinically based…”
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Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context by Matsukawa, Toshihiro, Yin, Mianmian, Baslan, Timour, Chung, Yang Jo, Cao, Dengchao, Bertoli, Ryan, Zhu, Yuelin J., Walker, Robert L., Freeland, Amy, Knudsen, Erik, Lowe, Scott W., Meltzer, Paul S., Aplan, Peter D.

“…Minichromosome maintenance proteins (Mcm2‐7) form a hexameric complex that unwinds DNA ahead of a replicative fork. The deficiency of Mcm proteins leads to…”
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Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL by Goldberg, Liat, Negi, Vijay, Chung, Yang Jo, Onozawa, Masahiro, Zhu, Yuelin J, Walker, Robert L, Pierce, Rachel, Patel, Daxesh P, Krausz, Kristopher W, Gonzalez, Frank J, Goodell, Margaret A, Rodriguez, Benjamin A T, Meltzer, Paul S, Aplan, Peter D

“…Mutations in the isocitrate dehydrogenase 1 ( ) and genes are frequently observed in a wide variety of hematologic malignancies, including myeloid and T-cell…”
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Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells by Yost, Kathryn E., Clatterbuck Soper, Sarah F., Walker, Robert L., Pineda, Marbin A., Zhu, Yuelin J., Ester, Corbin D., Showman, Soyeon, Roschke, Anna V., Waterfall, Joshua J., Meltzer, Paul S.

“…Many tumors maintain chromosome-ends through a telomerase-independent, DNA-templated mechanism called alternative lengthening of telomeres (ALT). While ALT…”
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