Search Results - "Zhu, Yuan O"

Precise estimates of mutation rate and spectrum in yeast by Zhu, Yuan O, Siegal, Mark L, Hall, David W, Petrov, Dmitri A

“…Mutation is the ultimate source of genetic variation. The most direct and unbiased method of studying spontaneous mutations is via mutation accumulation (MA)…”
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Whole Genome Analysis of 132 Clinical Saccharomyces cerevisiae Strains Reveals Extensive Ploidy Variation by Zhu, Yuan O, Sherlock, Gavin, Petrov, Dmitri A

“…Budding yeast has undergone several independent transitions from commercial to clinical lifestyles. The frequency of such transitions suggests that clinical…”
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Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney by Abedini, Amin, Zhu, Yuan O, Chatterjee, Shatakshee, Halasz, Gabor, Devalaraja-Narashimha, Kishor, Shrestha, Rojesh, S Balzer, Michael, Park, Jihwan, Zhou, Tong, Ma, Ziyuan, Sullivan, Katie Marie, Hu, Hailong, Sheng, Xin, Liu, Hongbo, Wei, Yi, Boustany-Kari, Carine M, Patel, Uptal, Almaani, Salem, Palmer, Matthew, Townsend, Raymond, Blady, Shira, Hogan, Jonathan, Morton, Lori, Susztak, Katalin

“…Microscopic analysis of urine sediment is probably the most commonly used diagnostic procedure in nephrology. The urinary cells, however, have not yet…”
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Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects by Plavskin, Yevgeniy, de Biase, Maria Stella, Ziv, Naomi, Janská, Libuše, Zhu, Yuan O, Hall, David W, Schwarz, Roland F, Tranchina, Daniel, Siegal, Mark L

“…The fitness effects of new mutations determine key properties of evolutionary processes. Beneficial mutations drive evolution, yet selection is also shaped by…”
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Selection Transforms the Landscape of Genetic Variation Interacting with Hsp90 by Geiler-Samerotte, Kerry A, Zhu, Yuan O, Goulet, Benjamin E, Hall, David W, Siegal, Mark L

“…The protein-folding chaperone Hsp90 has been proposed to buffer the phenotypic effects of mutations. The potential for Hsp90 and other putative buffers to…”
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Extremely Rare Polymorphisms in Saccharomyces cerevisiae Allow Inference of the Mutational Spectrum by Zhu, Yuan O, Sherlock, Gavin, Petrov, Dmitri A

“…The characterization of mutational spectra is usually carried out in one of three ways-by direct observation through mutation accumulation (MA) experiments,…”
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Patterns of mutation within an emerging endemic lineage of HEV‐3a by Zhu, Yuan O., Aw, Pauline, Aung, Myo Myint, Lee, Hong Kai, Hibberd, Martin, Lee, Guan Huei

“…Summary The hepatitis E virus can cause chronic infections in immuno‐suppressed patients, and cases have been on the rise globally. Viral mutations during such…”
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Defining a Unique Gene Expression Profile in Mature and Developing Keloids by Zhu, Yuan O., MacDonnell, Scott, Kaplan, Theodore, Liu, Chien, Ali, Yasmeen, Rangel, Stephanie M., Wipperman, Matthew F., Belback, Madeleine, Sun, Daphne S., Ren, Ziyou, Zhou, Xiaolong Alan, Halasz, Gabor, Morton, Lori, Kundu, Roopal V.

“…Keloids are benign, fibroproliferative dermal tumors that typically form owing to abnormal wound healing. The current standard of care is generally ineffective…”
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Single-virion sequencing of lamivudine-treated HBV populations reveal population evolution dynamics and demographic history by Zhu, Yuan O, Aw, Pauline P K, de Sessions, Paola Florez, Hong, Shuzhen, See, Lee Xian, Hong, Lewis Z, Wilm, Andreas, Li, Chen Hao, Hue, Stephane, Lim, Seng Gee, Nagarajan, Niranjan, Burkholder, William F, Hibberd, Martin

“…Viral populations are complex, dynamic, and fast evolving. The evolution of groups of closely related viruses in a competitive environment is termed…”
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Reply to Chen and Zhang: On interpreting genome-wide trends from yeast mutation accumulation data by Zhu, Yuan O, Siegal, Mark L, Hall, David W, Petrov, Dmitri A

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Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis by Zhou, Ye, Zhao, Yuanqi, Carbonaro, Marisa, Chen, Helen, Germino, Mary, Adler, Christina, Ni, Min, Zhu, Yuan O., Kim, Sun Y., Altarejos, Judith, Li, Zhe, Burczynski, Michael E., Glass, David J., Sleeman, Mark W., Lee, Ann-Hwee, Halasz, Gabor, Cheng, Xiping

“…Liver zonation characterizes the separation of metabolic pathways along the lobules and is required for optimal hepatic function. Wnt signaling is a master…”
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Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress by Lin, Wenwei, de Sessions, Paola Florez, Teoh, Garrett Hor Keong, Mohamed, Ahmad Naim Nazri, Zhu, Yuan O, Koh, Vanessa Hui Qi, Ang, Michelle Lay Teng, Dedon, Peter C, Hibberd, Martin Lloyd, Alonso, Sylvie

“…Increasing experimental evidence supports the idea that Mycobacterium tuberculosis has evolved strategies to survive within lysosomes of activated macrophages…”
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Multifactorial heterogeneity of virus-specific T cells and association with the progression of human chronic hepatitis B infection by Cheng, Yang, Zhu, Yuan O, Becht, Etienne, Aw, Pauline, Chen, Jinmiao, Poidinger, Michael, de Sessions, Paola Flórez, Hibberd, Martin Lloyd, Bertoletti, Antonio, Lim, Seng Gee, Newell, Evan W

“…Associations between chronic antigen stimulation, T cell dysfunction, and the expression of various inhibitory receptors are well characterized in several…”
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Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine by Skibinski, David A. G., Jones, Leigh Ann, Zhu, Yuan O., Xue, Lin Wu, Au, Bijin, Lee, Bernett, Naim, Ahmad Nazri Mohamed, Lee, Audrey, Kaliaperumal, Nivashini, Low, Jenny G. H., Lee, Lawrence S., Poidinger, Michael, Saudan, Philippe, Bachmann, Martin, Ooi, Eng Eong, Hanson, Brendon J., Novotny-Diermayr, Veronica, Matter, Alex, Fairhurst, Anna-Marie, Hibberd, Martin L., Connolly, John E.

“…Cell mediated immunity plays a vital role in defense against influenza infection in humans. Less is known about the role of vaccine-induced cell mediated…”
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Urinary Transcriptomics Identified Inflammatory Signals Associated With COVID-19-Related AKI: SA-OR04 by Eddy, Sean, Menon, Rajasree, Otto, Edgar A., Schaub, Jennifer A., Lienczewski, Chrysta C., Zhu, Yuan O., Boyapati, Anita, Devalaraja-Narashimha, Kishor B., Singh, Nikhil, Halasz, Gabor, Morton, Lori, Naik, Abhijit S., Kretzler, Matthias

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Precise estimates of mutation rate and spectrum in yeast by Zhu, Yuan O., Siegal, Mark L., Hall, David W., Petrov, Dmitri A.

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Abstract 2178: Circulating tumor DNA (ctDNA) correlates closely with tumor necrosis and relapse-free survival (RFS) in hepatocellular carcinoma (HCC) patients treated with perioperative cemiplimab by Marron, Thomas U., Brennan, Laura, Hamon, Pauline, Fiel, Maria Isabel, Ward, Stephen C., Zhu, Yuan O., Kim, Edward, Kamphorst, Alice O., Thanigaimani, Pradeep, Uldrick, Thomas S., Lucas, Natalie, Wu, Kathy, Hapanowicz, Olivia, King, Paula, Li, Siyu, Miller, Elizabeth, Bhardwaj, Nina, Thurston, Gavin, Lowy, Israel, Gnjatic, Sacha, Schwartz, Myron E., Jankovic, Vladimir, Merad, Miriam

“…Abstract Purpose: We evaluated ctDNA as a pharmacodynamic and predictive biomarker in patients (pts) with resectable HCC treated with cemiplimab…”
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