Search Results - "Zhu, Shouan"

3D-Printed Extracellular Matrix/Polyethylene Glycol Diacrylate Hydrogel Incorporating the Anti-inflammatory Phytomolecule Honokiol for Regeneration of Osteochondral Defects by Zhu, Shouan, Chen, Pengfei, Chen, Yang, Li, Muzhi, Chen, Can, Lu, Hongbin

“…Background: Osteoarthritis is the leading cause of disability worldwide; cartilage degeneration and defects are the central features. Significant progress in…”
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Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis by Chen, Hao, Hu, Bo, Lv, Xiao, Zhu, Shouan, Zhen, Gehua, Wan, Mei, Jain, Amit, Gao, Bo, Chai, Yu, Yang, Mi, Wang, Xiao, Deng, Ruoxian, Wang, Lei, Cao, Yong, Ni, Shuangfei, Liu, Shen, Yuan, Wen, Chen, Huajiang, Dong, Xinzhong, Guan, Yun, Yang, Huilin, Cao, Xu

“…Whether sensory nerve can sense bone density or metabolic activity to control bone homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by…”
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Mechanical stress determines the configuration of TGFβ activation in articular cartilage by Zhen, Gehua, Guo, Qiaoyue, Li, Yusheng, Wu, Chuanlong, Zhu, Shouan, Wang, Ruomei, Guo, X. Edward, Kim, Byoung Choul, Huang, Jessie, Hu, Yizhong, Dan, Yang, Wan, Mei, Ha, Taekjip, An, Steven, Cao, Xu

“…Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development of disease-modifying therapy. The functional…”
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Macrophage-lineage TRAP+ cells recruit periosteum-derived cells for periosteal osteogenesis and regeneration by Gao, Bo, Deng, Ruoxian, Chai, Yu, Chen, Hao, Hu, Bo, Wang, Xiao, Zhu, Shouan, Cao, Yong, Ni, Shuangfei, Wan, Mei, Yang, Liu, Luo, Zhuojing, Cao, Xu

“…The periosteum, a thin tissue that covers almost the entire bone surface, accounts for more than 80% of human bone mass and is essential for bone regeneration…”
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Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain by Zhu, Shouan, Zhu, Jianxi, Zhen, Gehua, Hu, Yihe, An, Senbo, Li, Yusheng, Zheng, Qin, Chen, Zhiyong, Yang, Ya, Wan, Mei, Skolasky, Richard Leroy, Cao, Yong, Wu, Tianding, Gao, Bo, Yang, Mi, Gao, Manman, Kuliwaba, Julia, Ni, Shuangfei, Wang, Lei, Wu, Chuanlong, Findlay, David, Eltzschig, Holger K, Ouyang, Hong Wei, Crane, Janet, Zhou, Feng-Quan, Guan, Yun, Dong, Xinzhong, Cao, Xu

“…Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role of…”
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Musculoskeletal Effects of Altered GH Action by Young, Jonathan A, Zhu, Shouan, List, Edward O, Duran-Ortiz, Silvana, Slama, Yosri, Berryman, Darlene E

“…Growth hormone (GH) is a peptide hormone that can signal directly through its receptor or indirectly through insulin-like growth factor 1 (IGF-1) stimulation…”
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Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo by Zhu, Shouan, Lu, Ping, Liu, Huanhuan, Chen, Pengfei, Wu, Yan, Wang, Yanyan, Sun, Heng, Zhang, Xiaolei, Xia, Qingqing, Heng, Boon Chin, Zhou, Yiting, Ouyang, Hong Wei

“…Osteoarthritis (OA) is a degenerative joint disease characterised by cartilage degradation and chondrocyte hypertrophy. A recent study showed that Rac1…”
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Intra‐Articular Transplantation of Atsttrin‐Transduced Mesenchymal Stem Cells Ameliorate Osteoarthritis Development by Xia, Qingqing, Zhu, Shouan, Wu, Yan, Wang, Jiaqiu, Cai, Youzhi, Chen, Pengfei, Li, Jie, Heng, Boon Chin, Ouyang, Hong Wei, Lu, Ping

“…Osteoarthritis (OA) remains an intractable clinical challenge. Few drugs are available for reversing this degenerative disease, although some promising…”
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Editorial: Integrative Physiology of Common Chronic Musculoskeletal Disorders by Clark, Brian C., Grooms, Dustin R., Etheridge, Timothy, Wilkinson, Daniel J., Zhu, Shouan, Arnold, W. David, Szewczyk, Nathaniel J.

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Down‐Regulation of Rac GTPase‐Activating Protein OCRL1 Causes Aberrant Activation of Rac1 in Osteoarthritis Development by Zhu, Shouan, Dai, Jun, Liu, Huanhuan, Cong, Xiaoxia, Chen, Yishan, Wu, Yan, Hu, Hu, Heng, Boon Chin, Ouyang, Hong Wei, Zhou, Yiting

“…Objective Chondrocyte hypertrophy and mineralization are considered to be important pathologic factors in osteoarthritis (OA). We previously reported that Rac1…”
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Growth hormone-receptor disruption in mice reduces osteoarthritis and chondrocyte hypertrophy by Liu, Huanhuan, Davis, Trent, Duran-Ortiz, Silvana, Martino, Tom, Erdely, Austin, Profio, Shane, Osipov, Benjamin, Loots, Gabriela G., Berryman, Darlene E., O’Connor, Patrick M., Kopchick, John J., Zhu, Shouan

“…Excessive growth hormone (GH) has been shown to promote joint degeneration in both preclinical and clinical studies. Little is known about the effect of…”
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High-Resolution Dissection of Chemical Reprogramming from Mouse Embryonic Fibroblasts into Fibrocartilaginous Cells by Chen, Yishan, Wu, Bingbing, Lin, Junxin, Yu, Dongsheng, Du, Xiaotian, Sheng, Zixuan, Yu, Yeke, An, Chengrui, Zhang, Xiaoan, Li, Qikai, Zhu, Shouan, Sun, Heng, Zhang, Xianzhu, Zhang, Shufang, Zhou, Jing, Bunpetch, Varitsara, El-Hashash, Ahmed, Ji, Junfeng, Ouyang, Hongwei

“…Articular cartilage injury and degeneration causing pain and loss of quality-of-life has become a serious problem for increasingly aged populations. Given the…”
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Programmed Application of Transforming Growth Factor β3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose‐Derived Stem Cells for Osteochondral Defect Repair by Zhu, Shouan, Chen, Pengfei, Wu, Yan, Xiong, Si, Sun, Heng, Xia, Qingqing, Shi, Libing, Liu, Huanhuan, Ouyang, Hong Wei

“…Hyaline cartilage differentiation is always the challenge with application of stem cells for joint repair. Transforming growth factors (TGFs) and bone…”
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SIRT5 REGULATES CHOONDROCYTE METABOLIC DYSFUNCTIONS AND OSTEOARTHRITIS DEVELOPMENT DURING AGING AND OBESITY by Liu, Huanhuan, Zhu, Shouan

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604 - SIRT5 REGULATES CHOONDROCYTE METABOLIC DYSFUNCTIONS AND OSTEOARTHRITIS DEVELOPMENT DURING AGING AND OBESITY by Liu, Huanhuan, Zhu, Shouan

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GROWTH HORMONE PROMOTES JOINT DEGENERATION AND CHONDROCYTE METABOLIC DYSFUNCTION IN MICE by Zhu, Shouan, Liu, Huanhuan, Kopchick, John J.

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603 - GROWTH HORMONE PROMOTES JOINT DEGENERATION AND CHONDROCYTE METABOLIC DYSFUNCTION IN MICE by Zhu, Shouan, Liu, Huanhuan, Kopchick, John J.

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Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing by Chen, Pengfei, Tao, Jiadong, Zhu, Shouan, Cai, Youzhi, Mao, Qijiang, Yu, Dongsheng, Dai, Jun, Ouyang, HongWei

“…Abstract The migration of cells from the side and the bottom of the defect is important in osteochondral defect healing. Here, we designed a novel collagen…”
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Silk fibroin-chondroitin sulfate scaffold with immuno-inhibition property for articular cartilage repair by Zhou, Feifei, Zhang, Xianzhu, Cai, Dandan, Li, Jun, Mu, Qin, Zhang, Wei, Zhu, Shouan, Jiang, Yangzi, Shen, Weiliang, Zhang, Shufang, Ouyang, Hong Wei

“…[Display omitted] The demand of favorable scaffolds has increased for the emerging cartilage tissue engineering. Chondroitin sulfate (CS) and silk fibroin have…”
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Kdm6b regulates cartilage development and homeostasis through anabolic metabolism by Dai, Jun, Yu, Dongsheng, Wang, Yafei, Chen, Yishan, Sun, Heng, Zhang, Xiaolei, Zhu, Shouan, Pan, Zongyou, Heng, Boon Chin, Zhang, Shufang, Ouyang, Hongwei

“…Epigenetic mechanisms have been reported to play key roles in chondrogenesis and osteoarthritis (OA) development. Here, we sought to identify specific histone…”
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