Prevalence and genotype distribution of human papillomavirus infection among women: A population‐based study in Dali Bai Autonomous Prefecture, Yunnan Province, China

Prevalence and genotype distribution of human papillomavirus infection among women: A population‐based study in Dali Bai Autonomous Prefecture, Yunnan Province, China

Accumulating evidence indicates that persistent infection with high‐risk oncogenic human papillomavirus (HPV) genotypes is the most important risk factor for cervical cancer, and that the distribution of HPV genotypes varies regionally. This study explored the prevalence and genotype distribution of...

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Bibliographic Details
Published in:Journal of medical virology Vol. 91; no. 8; pp. 1553 - 1561
Main Authors: Su, Ya, Yuan, Zhiqiong, Xu, Chunping, Li, Zhengjin, Zhu, Renjian, Zhang, Wei, Cao, Rongrong, Yan, Xuyi, Liu, Yunchun
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-08-2019
Subjects:
Cervical cancer
Cervix
Diagnostic systems
epidemiology
ethnic
Fertility
Genotype & phenotype
genotype distribution
Genotypes
Geographical variations
Health risk assessment
Health risks
Human papillomavirus
Infections
Medical screening
Population (statistical)
Population studies
Population-based studies
Regression analysis
Risk analysis
Risk factors
Risk reduction
Statistical analysis
Statistical methods
Virology
China
Yunnan China
epidemiology
ethnic
genotype distribution
human papillomavirus
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Summary:Accumulating evidence indicates that persistent infection with high‐risk oncogenic human papillomavirus (HPV) genotypes is the most important risk factor for cervical cancer, and that the distribution of HPV genotypes varies regionally. This study explored the prevalence and genotype distribution of HPV infection among Han, Yi, and Bai women in various regions of Dali Bai Autonomous Prefecture, Yunnan Province, China. This cross‐sectional study included 2779 women (20–76 years old) who were referred for 21‐HPV genotype array diagnostic from five regions of Dali Bai Autonomous Prefecture between February 2013 and May 2016. Statistical methods used included a the χ2 test, Fisher's exact test, t test, and logistic regression. Overall HPV prevalence in the study population was 7.6%. HPV‐52, HPV‐58, HPV‐18, HPV‐81, and HPV‐16 were the most prevalent genotypes in the study area, and notably, the prevalence of HPV‐58 was significantly higher among women in Heqing County than that in other regions. Univariate analysis showed that husband's age, region, fertility status, and parity were potential factors associated with HPV infection. Multivariate logistic regression analysis revealed that Heqing County was an independent risk factor for HPV infection among women in the Dali area, moreover, Yi women showed the highest risk for HPV infections. Overall, our finding emphasizing the urgent need for an HPV screening and prevention program in Heqing County and Yi women. We also suggest that HPV‐related health education should be provided not only to women, but also to men, to reduce the risk of infection in women. Highlight The HPV prevalence was 7.6% among Han, Yi, and Bai women in various regions of Dali Bai Autonomous Prefecture, Yunnan Province, China. HPV‐52, HPV‐58, HPV‐18, HPV‐81, and HPV‐16 were the most prevalent genotypes in the study area. Heqing County was an independent risk factor for HPV infection among women in the Dali area, and the prevalence of HPV‐58 was significantly higher among women in Heqing County than that in other regions. Yi women showed the highest risk for HPV infections.
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ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.25477