Search Results - "Zhu, Lihua J"

Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants by Bansal, Ankita, Zhu, Lihua J, Yen, Kelvin, Tissenbaum, Heidi A

“…Aging research has been very successful at identifying signaling pathways and evolutionarily conserved genes that extend lifespan with the assumption that an…”
Get full text

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome by Oslowski, Christine M., Hara, Takashi, O'Sullivan-Murphy, Bryan, Kanekura, Kohsuke, Lu, Simin, Hara, Mariko, Ishigaki, Shinsuke, Zhu, Lihua J., Hayashi, Emiko, Hui, Simon T., Greiner, Dale, Kaufman, Randal J., Bortell, Rita, Urano, Fumihiko

“…Recent clinical and experimental evidence suggests that endoplasmic reticulum (ER) stress contributes to the life-and-death decisions of β cells during the…”
Get full text

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo by Yin, Hao, Song, Chun-Qing, Dorkin, Joseph R, Zhu, Lihua J, Li, Yingxiang, Wu, Qiongqiong, Park, Angela, Yang, Junghoon, Suresh, Sneha, Bizhanova, Aizhan, Gupta, Ankit, Bolukbasi, Mehmet F, Walsh, Stephen, Bogorad, Roman L, Gao, Guangping, Weng, Zhiping, Dong, Yizhou, Koteliansky, Victor, Wolfe, Scot A, Langer, Robert, Xue, Wen, Anderson, Daniel G

“…Cas9-mediated gene editing corrects hereditary tyrosinemia in a mouse model. The combination of Cas9, guide RNA and repair template DNA can induce precise gene…”
Get full text

Jmjd3-Mediated H3K27me3 Dynamics Orchestrate Brown Fat Development and Regulate White Fat Plasticity by Pan, Dongning, Huang, Lei, Zhu, Lihua J., Zou, Tie, Ou, Jianhong, Zhou, William, Wang, Yong-Xu

“…Progression from brown preadipocytes to adipocytes engages two transcriptional programs: the expression of adipogenic genes common to both brown fat (BAT) and…”
Get full text

ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data by Zhu, Lihua J, Gazin, Claude, Lawson, Nathan D, Pagès, Hervé, Lin, Simon M, Lapointe, David S, Green, Michael R

“…Chromatin immunoprecipitation (ChIP) followed by high-throughput sequencing (ChIP-seq) or ChIP followed by genome tiling array analysis (ChIP-chip) have become…”
Get full text

CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems by Zhu, Lihua J, Holmes, Benjamin R, Aronin, Neil, Brodsky, Michael H

“…CRISPR-Cas systems are a diverse family of RNA-protein complexes in bacteria that target foreign DNA sequences for cleavage. Derivatives of these complexes…”
Get full text

The Three-Dimensional Architecture of a Bacterial Genome and Its Alteration by Genetic Perturbation by Umbarger, Mark A., Toro, Esteban, Wright, Matthew A., Porreca, Gregory J., Baù, Davide, Hong, Sun-Hae, Fero, Michael J., Zhu, Lihua J., Marti-Renom, Marc A., McAdams, Harley H., Shapiro, Lucy, Dekker, Job, Church, George M.

“…We have determined the three-dimensional (3D) architecture of the Caulobacter crescentus genome by combining genome-wide chromatin interaction detection,…”
Get full text

Tead and AP1 Coordinate Transcription and Motility by Liu, Xiangfan, Li, Huapeng, Rajurkar, Mihir, Li, Qi, Cotton, Jennifer L., Ou, Jianhong, Zhu, Lihua J., Goel, Hira L., Mercurio, Arthur M., Park, Joo-Seop, Davis, Roger J., Mao, Junhao

“…The Tead family transcription factors are the major intracellular mediators of the Hippo-Yap pathway. Despite the importance of Hippo signaling in…”
Get full text

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription by Li, Qi, Sun, Yang, Jarugumilli, Gopala K., Liu, Shun, Dang, Kyvan, Cotton, Jennifer L., Xiol, Jordi, Chan, Pui Yee, DeRan, Michael, Ma, Lifang, Li, Rui, Zhu, Lihua J., Li, Joyce H., Leiter, Andrew B., Ip, Y. Tony, Camargo, Fernando D., Luo, Xuelian, Johnson, Randy L., Wu, Xu, Mao, Junhao

“…Intestinal homeostasis is tightly regulated by complex yet poorly understood signaling networks. Here, we demonstrate that Lats1/2, the core Hippo kinases, are…”
Get full text

miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development by Nicoli, Stefania, Knyphausen, Carl-Philipp, Zhu, Lihua J., Lakshmanan, Abirami, Lawson, Nathan D.

“…Angiogenesis requires coordination of distinct cell behaviors between tip and stalk cells. Although this process is governed by regulatory interactions between…”
Get full text

TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein by Bhatnagar, Sanchita, Gazin, Claude, Chamberlain, Lynn, Ou, Jianhong, Zhu, Xiaochun, Tushir, Jogender S., Virbasius, Ching-Man, Lin, Ling, Zhu, Lihua J., Wajapeyee, Narendra, Green, Michael R.

“…The RING finger protein TRIM37 is encoded by a gene that is amplified in certain breast cancers, but its function is unknown; here, it is shown to…”
Get full text

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases by Meng, Xiangdong, Noyes, Marcus B, Lawson, Nathan D, Wolfe, Scot A, Zhu, Lihua J

“…Direct genomic manipulation at a specific locus is still not feasible in most vertebrate model organisms. In vertebrate cell lines, genomic lesions at a…”
Get full text

Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors by Shin, Masahiro, Male, Ira, Beane, Timothy J, Villefranc, Jacques A, Kok, Fatma O, Zhu, Lihua J, Lawson, Nathan D

“…Vascular endothelial growth factor C (Vegfc) activates its receptor, Flt4, to induce lymphatic development. However, the signals that act downstream of Flt4 in…”
Get full text

Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation by Huang, Lei, Pan, Dongning, Chen, Qingbo, Zhu, Lihua J., Ou, Jianhong, Wabitsch, Martin, Wang, Yong-Xu

“…Browning of subcutaneous white fat (iWAT) involves several reprograming events, but the underlying mechanisms are incompletely understood. Here we show that…”
Get full text

Global Promotion of Alternative Internal Exon Usage by mRNA 3′ End Formation Factors by Misra, Ashish, Ou, Jianhong, Zhu, Lihua J., Green, Michael R.

“…The mechanisms that regulate alternative precursor mRNA (pre-mRNA) splicing are largely unknown. Here, we perform an RNAi screen to identify factors required…”
Get full text

MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway by Janostiak, Radoslav, Rauniyar, Navin, Lam, TuKiet T., Ou, Jianhong, Zhu, Lihua J., Green, Michael R., Wajapeyee, Narendra

“…Melanoma accounts for more than 80% of skin cancer-related deaths, and current therapies provide only short-term benefit to patients. Here, we show in melanoma…”
Get full text

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription by Sheng, Zhi, Ma, Leyuan, Sun, Jiaoyuan E., Zhu, Lihua J., Green, Michael R.

“…The oncoprotein BCR-ABL transforms myeloid progenitor cells and is responsible for the development of chronic myeloid leukemia (CML). In transformed cells,…”
Get full text

YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression by Li, Huapeng, Li, Qi, Dang, Kyvan, Ma, Shan, Cotton, Jennifer L., Yang, Sun, Zhu, Lihua J., Deng, April C., Ip, Y. Tony, Johnson, Randy L., Wu, Xu, Punzo, Claudio, Mao, Junhao

“…Uveal melanoma (UM), the most common ocular malignancy, is characterized by GNAQ/11 mutations. Hippo/YAP and Ras/mitogen-activated protein kinase (MAPK) emerge…”
Get full text

A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia by Ma, Leyuan, Shan, Yi, Bai, Robert, Xue, Liting, Eide, Christopher A, Ou, Jianhong, Zhu, Lihua J, Hutchinson, Lloyd, Cerny, Jan, Khoury, Hanna Jean, Sheng, Zhi, Druker, Brian J, Li, Shaoguang, Green, Michael R

“…Resistance to the BCR-ABL inhibitor imatinib mesylate (IM) poses a major problem for the treatment of chronic myeloid leukemia (CML). IM resistance often…”
Get more information

Genetic and pharmacological reactivation of the mammalian inactive X chromosome by Bhatnagar, Sanchita, Zhu, Xiaochun, Ou, Jianhong, Lin, Ling, Chamberlain, Lynn, Zhu, Lihua J., Wajapeyee, Narendra, Green, Michael R.

“…X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal…”
Get full text