Search Results - "Zhu, Jingen"

Understanding Bacteriophage Tail Fiber Interaction with Host Surface Receptor: The Key "Blueprint" for Reprogramming Phage Host Range by Taslem Mourosi, Jarin, Awe, Ayobami, Guo, Wenzheng, Batra, Himanshu, Ganesh, Harrish, Wu, Xiaorong, Zhu, Jingen

“…Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because of the growing threat of multi- and pan-drug-resistant bacterial…”
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Design of bacteriophage T4-based artificial viral vectors for human genome remodeling by Zhu, Jingen, Batra, Himanshu, Ananthaswamy, Neeti, Mahalingam, Marthandan, Tao, Pan, Wu, Xiaorong, Guo, Wenzheng, Fokine, Andrei, Rao, Venigalla B.

“…Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter human cells and carry out molecular repairs will have broad applications…”
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Higher-Ordered Actin Structures Remodeled by Arabidopsis ACTIN-DEPOLYMERIZING FACTOR5 Are Important for Pollen Germination and Pollen Tube Growth by Zhu, Jingen, Nan, Qiong, Qin, Tao, Qian, Dong, Mao, Tonglin, Yuan, Shunjie, Wu, Xiaorong, Niu, Yue, Bai, Qifeng, An, Lizhe, Xiang, Yun

“…Dynamics of the actin cytoskeleton are essential for pollen germination and pollen tube growth. ACTIN- DEPOLYMERIZlNG FACTORs （ADFs） typically contribute to…”
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Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair by Wu, Xiaorong, Zhu, Jingen, Tao, Pan, Rao, Venigalla B

“…Bacteria and bacteriophages (phages) have evolved potent defense and counterdefense mechanisms that allowed their survival and greatest abundance on Earth…”
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A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague by Tao, Pan, Mahalingam, Marthandan, Zhu, Jingen, Moayeri, Mahtab, Sha, Jian, Lawrence, William S, Leppla, Stephen H, Chopra, Ashok K, Rao, Venigalla B

“…and , the causative agents of anthrax and plague, respectively, are two of the deadliest pathogenic bacteria that have been used as biological warfare agents…”
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A Bacteriophage-Based, Highly Efficacious, Needle- and Adjuvant-Free, Mucosal COVID-19 Vaccine by Zhu, Jingen, Jain, Swati, Sha, Jian, Batra, Himanshu, Ananthaswamy, Neeti, Kilgore, Paul B, Hendrix, Emily K, Hosakote, Yashoda M, Wu, Xiaorong, Olano, Juan P, Kayode, Adeyemi, Galindo, Cristi L, Banga, Simran, Drelich, Aleksandra, Tat, Vivian, Tseng, Chien-Te K, Chopra, Ashok K, Rao, Venigalla B

“…The U.S. Food and Drug Administration-authorized mRNA- and adenovirus-based SARS-CoV-2 vaccines are intramuscularly injected in two doses and effective in…”
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Arabidopsis CROLIN1, a Novel Plant Actin-binding Protein, Functions in Cross-linking and Stabilizing Actin Filaments by Jia, Honglei, Li, Jisheng, Zhu, Jingen, Fan, Tingting, Qian, Dong, Zhou, Yuelong, Wang, Jiaojiao, Ren, Haiyun, Xiang, Yun, An, Lizhe

“…Higher order actin filament structures are necessary for cytoplasmic streaming, organelle movement, and other physiological processes. However, the mechanism…”
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Preparation of a Bacteriophage T4-based Prokaryotic-eukaryotic Hybrid Viral Vector for Delivery of Large Cargos of Genes and Proteins into Human Cells by Zhu, Jingen, Tao, Pan, Mahalingam, Marthandan, Rao, Venigalla B

“…A viral vector that can safely and efficiently deliver large and diverse molecular cargos into cells is the holy grail of curing many human diseases…”
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A Bivalent Anthrax-Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis by Tao, Pan, Mahalingam, Marthandan, Zhu, Jingen, Moayeri, Mahtab, Kirtley, Michelle L, Fitts, Eric C, Andersson, Jourdan A, Lawrence, William S, Leppla, Stephen H, Chopra, Ashok K, Rao, Venigalla B

“…Bioterrorism remains as one of the biggest challenges to global security and public health. Since the deadly anthrax attacks of 2001 in the United States, and…”
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Gelsolin-Like Domain 3 Plays Vital Roles in Regulating the Activities of the Lily Villin/Gelsolin/Fragmin Superfamily by Qian, Dong, Nan, Qiong, Yang, Yueming, Li, Hui, Zhou, Yuelong, Zhu, Jingen, Bai, Qifeng, Zhang, Pan, An, Lizhe, Xiang, Yun

“…The villin/gelsolin/fragmin superfamily is a major group of Ca2+-dependent actin-binding proteins (ABPs) involved in various cellular processes. Members of…”
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Annexin5 plays a vital role in Arabidopsis pollen development via Ca2+-dependent membrane trafficking by Zhu, Jingen, Wu, Xiaorong, Yuan, Shunjie, Qian, Dong, Nan, Qiong, An, Lizhe, Xiang, Yun

“…The regulation of pollen development and pollen tube growth is a complicated biological process that is crucial for sexual reproduction in flowering plants…”
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Save young lives by determining causes of children death stratified by HIV status in resource-constrained countries by Zhu, Jingen, Wu, Xiaorong

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Bacteriophage T4 nanoparticles for vaccine delivery against infectious diseases by Tao, Pan, Zhu, Jingen, Mahalingam, Marthandan, Batra, Himanshu, Rao, Venigalla B.

“…Subunit vaccines containing one or more target antigens from pathogenic organisms represent safer alternatives to whole pathogen vaccines. However, the…”
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Bacteriophage T4 as a nanovehicle for delivery of genes and therapeutics into human cells by Rao, Venigalla B, Zhu, Jingen

“…The ability to deliver therapeutic genes and biomolecules into a human cell and restore a defective function has been the holy grail of medicine…”
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Covalent Modifications of the Bacteriophage Genome Confer a Degree of Resistance to Bacterial CRISPR Systems by Liu, Yuepeng, Dai, Li, Dong, Junhua, Chen, Cen, Zhu, Jingen, Rao, Venigalla B, Tao, Pan

“…The interplay between defense and counterdefense systems of bacteria and bacteriophages has been driving the evolution of both organisms, leading to their…”
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Engineering of Bacteriophage T4 Genome Using CRISPR-Cas9 by Tao, Pan, Wu, Xiaorong, Tang, Wei-Chun, Zhu, Jingen, Rao, Venigalla

“…Bacteriophages likely constitute the largest biomass on Earth. However, very few phage genomes have been well-characterized, the tailed phage T4 genome being…”
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CRISPR Engineering of Bacteriophage T4 to Design Vaccines Against SARS-CoV-2 and Emerging Pathogens by Zhu, Jingen, Ananthaswamy, Neeti, Jain, Swati, Batra, Himanshu, Tang, Wei-Chun, Rao, Venigalla B

“…The COVID-19 pandemic brought to the fore the urgent need for vaccine design and delivery platforms that can be rapidly deployed for manufacture and…”
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T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines by Li, Mengling, Chen, Cen, Wang, Xialin, Guo, Pengju, Feng, Helong, Zhang, Xueqi, Zhang, Wanpo, Gu, Changqin, Zhu, Jingen, Wen, Guoyuan, Feng, Yaoyu, Xiao, Lihua, Peng, Guiqing, Rao, Venigalla B., Tao, Pan

“…Vaccines that trigger mucosal immune responses at the entry portals of pathogens are highly desired. Here, we showed that antigen-decorated nanoparticle…”
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Bacteriophage T4 as a Protein-Based, Adjuvant- and Needle-Free, Mucosal Pandemic Vaccine Design Platform by Zhu, Jingen, Tao, Pan, Chopra, Ashok K, Rao, Venigalla B

“…The COVID-19 pandemic has transformed vaccinology. Rapid deployment of mRNA vaccines has saved countless lives. However, these platforms have inherent…”
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Engineering T4 Bacteriophage for In Vivo Display by Type V CRISPR-Cas Genome Editing by Dong, Junhua, Chen, Cen, Liu, Yuepeng, Zhu, Jingen, Li, Mengling, Rao, Venigalla B, Tao, Pan

“…Bacteriophage T4 has enormous potential for biomedical applications due to its large size, capsid architecture, and high payload capability for protein and DNA…”
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