Search Results - "Zhu, Iowis"

Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis by Lu, Jinghua, Yu, Yadong, Zhu, Iowis, Cheng, Yifan, Sun, Peter D.

“…Serum amyloid A (SAA) represents an evolutionarily conserved family of inflammatory acute-phase proteins. It is also a major constituent of secondary…”
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Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor by Liu, Xiaoyang, Palaniyandi, Senthilkumar, Zhu, Iowis, Tang, Jin, Li, Weizhong, Wu, Xiaoling, Ochsner, Susan Park, Pauza, C. David, Cohen, Jeffrey I., Zhu, Xiaoping

“…Human cytomegalovirus (HCMV) can persistently infect humans, but how HCMV avoids humoral immunity is not clear. The neonatal Fc receptor (FcRn) controls IgG…”
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Management of Concurrent Malignant Phyllodes Tumor and Invasive Breast Carcinoma by Chen, Jie Jane, Zhu, Iowis, Patel, Akshat, Krings, Gregor, Chen, Yunn-Yi, Yuen, Florence, Mukhtar, Rita A., Melisko, Michelle, Singer, Lisa, Park, Catherine C., Prionas, Nicolas D.

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Modular design of synthetic receptors for programmed gene regulation in cell therapies by Zhu, Iowis, Liu, Raymond, Garcia, Julie M., Hyrenius-Wittsten, Axel, Piraner, Dan I., Alavi, Josef, Israni, Divya V., Liu, Bin, Khalil, Ahmad S., Roybal, Kole T.

“…Synthetic biology has established powerful tools to precisely control cell function. Engineering these systems to meet clinical requirements has enormous…”
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Naturally occurring T cell mutations enhance engineered T cell therapies by Garcia, Julie, Daniels, Jay, Lee, Yujin, Zhu, Iowis, Cheng, Kathleen, Liu, Qing, Goodman, Daniel, Burnett, Cassandra, Law, Calvin, Thienpont, Chloë, Alavi, Josef, Azimi, Camillia, Montgomery, Garrett, Roybal, Kole T., Choi, Jaehyuk

“…Adoptive T cell therapies have produced exceptional responses in a subset of patients with cancer. However, therapeutic efficacy can be hindered by poor T cell…”
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RBIO-07. IMMUNOMODULATORY PATHWAYS MEDIATE RADIOTHERAPY RESPONSE IN MALIGNANT PERIPHERAL NERVE SHEATH TUMORS by Zhu, Iowis, Chien, Julian, Mirchia, Kanish, Miller, Kaeli, Payne, Emily, Pak, Joanna, Monga, Varun, Braunstein, Steve, Jacques, Line, Pekmezci, Melike, Liu, John, Vasudevan, Harish

“…Abstract PURPOSE Malignant peripheral nerve sheath tumors (MPNSTs) are the most common cause of death in neurofibromatosis type 1 (NF-1) and are resistant to…”
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Synthesizing a Smarter CAR T Cell: Advanced Engineering of T-cell Immunotherapies by Zhu, Iowis, Piraner, Dan I, Roybal, Kole T

“…The immune system includes an array of specialized cells that keep us healthy by responding to pathogenic cues. Investigations into the mechanisms behind…”
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Next Generation Receptors for the Enhanced Control of Cell-Based Immunotherapies by Zhu, Iowis

“…Many potential immunotherapies are hindered by poor efficacies and unacceptable toxicities, such as on-target, off-tumor toxicity. In contrast to constitutive…”
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Naturally Occurring Mutations in Human T Cell Lymphomas Enhance Engineered T Cell Therapies by Garcia, Julie, Daniels, Jay, Lee, Yujin, Zhu, Iowis, Cheng, Kathleen, Liu, Qing, Goodman, Daniel, Burnett, Cassandra, Law, Calvin, Thienpoint, Chloe, Alavi, Josef, Azimi, Camillia, Montgomery, Garrett, Roybal, Kole, Choi, Jaehyuk

“…T cell therapies, including chimeric antigen receptor (CAR) T cells, have revolutionized cancer therapy. However, impressive responses are limited to a subset…”
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Engineered receptors for soluble cellular communication and disease sensing by Piraner, Dan I., Abedi, Mohamad H., Duran Gonzalez, Maria J., Chazin-Gray, Adam, Lin, Annie, Zhu, Iowis, Ravindran, Pavithran T., Schlichthaerle, Thomas, Huang, Buwei, Bearchild, Tyler H., Lee, David, Wyman, Sarah, Jun, Young-wook, Baker, David, Roybal, Kole T.

“…Despite recent advances in mammalian synthetic biology, there remains a lack of modular synthetic receptors that can robustly respond to soluble ligands and in…”
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Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma by Shin, Jaehoon, Parker, Matthew F L, Zhu, Iowis, Alanizi, Aryn, Rodriguez, Carlos I, Liu, Raymond, Watchmaker, Payal B, Kalita, Mausam, Blecha, Joseph, Luu, Justin, Wright, Brian, Lapi, Suzanne E, Flavell, Robert R, Okada, Hideho, Tlsty, Thea D, Roybal, Kole T, Wilson, David M

“…For the past several decades, chimeric antigen receptor T-cell therapies have shown promise in the treatment of cancers. These treatments would greatly benefit…”
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Synthetic biology: at the crossroads of genetic engineering and human therapeutics—a Keystone Symposia report by Cable, Jennifer, Leonard, Joshua N., Lu, Timothy K., Xie, Zhen, Chang, Matthew Wook, Fernández, Luis Ángel, Lora, José M., Kaufman, Howard L., Quintana, Francisco J., Geiger, Roger, F. Lesser, Cammie, Lynch, Jason P., Hava, David L., Cornish, Virginia W., Lee, Gary K., DiAndreth, Breanna, Fero, Michael, Srivastava, Rajkamal, De Coster, Tim, Roybal, Kole T., Rackham, Owen J. L., Kiani, Samira, Zhu, Iowis, Hernandez‐Lopez, Rogelio A., Guo, Tingxi, Chen, William C. W.

“…Synthetic biology has the potential to transform cell‐ and gene‐based therapies for a variety of diseases. Sophisticated tools are now available for both…”
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Management of Concurrent Malignant Phyllodes Tumor and Invasive Breast Carcinoma by Chen, Jie Jane, Zhu, Iowis, Patel, Akshat, Krings, Gregor, Chen, Yunn-Yi, Yuen, Florence, Mukhtar, Rita A, Melisko, Michelle, Singer, Lisa, Park, Catherine C, Prionas, Nicolas D

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