Search Results - "Zhu, Hengrui"

BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression by Zhu, Hengrui, Bengsch, Fee, Svoronos, Nikolaos, Rutkowski, Melanie R., Bitler, Benjamin G., Allegrezza, Michael J., Yokoyama, Yuhki, Kossenkov, Andrew V., Bradner, James E., Conejo-Garcia, Jose R., Zhang, Rugang

“…Restoration of anti-tumor immunity by blocking PD-L1 signaling through the use of antibodies has proven to be beneficial in cancer therapy. Here, we show…”
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BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer by Karakashev, Sergey, Zhu, Hengrui, Yokoyama, Yuhki, Zhao, Bo, Fatkhutdinov, Nail, Kossenkov, Andrew V., Wilson, Andrew J., Simpkins, Fiona, Speicher, David, Khabele, Dineo, Bitler, Benjamin G., Zhang, Rugang

“…PARP inhibition is known to be an effective clinical strategy in BRCA mutant cancers, but PARP inhibition has not been applied to BRCA-proficient tumors. Here,…”
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Pulsar Double Lensing Sheds Light on the Origin of Extreme Scattering Events by Zhu, Hengrui, Baker, Daniel, Pen, Ue-Li, Stinebring, Dan R., van Kerkwijk, Marten H.

“…Abstract In extreme scattering events, the brightness of a compact radio source drops significantly, as light is refracted out of the line of sight by…”
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Geochronology and geochemistry of ore-hosted zircon reveal the genesis of typical Sb-(Au-W) deposits in South China by Zhou, Zhekai, Li, Huan, Zhu, Hengrui, Ghaderi, Majid, Ouyang, Liming

“…[Display omitted] •Sources of ore-hosted zircons are different for the Xikuangshan and Woxi deposits.•Ore-hosted zircons suffered hydrothermal alteration at…”
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In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor by Xie, Fang, Zhu, Hengrui, Zhang, Haoxing, Lang, Qingyu, Tang, Lisha, Huang, Qiang, Yu, Long

“…Aurora B is a serine/threonine kinase that has a key role in mitosis and is overexpressed in cancer cells. Aberrations in Aurora B are highly correlated with…”
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CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity by Karakashev, Sergey, Zhu, Hengrui, Wu, Shuai, Yokoyama, Yuhki, Bitler, Benjamin G., Park, Pyoung-Hwa, Lee, Jeong-Heon, Kossenkov, Andrew V., Gaonkar, Krutika Satish, Yan, Huihuang, Drapkin, Ronny, Conejo-Garcia, Jose R., Speicher, David W., Ordog, Tamas, Zhang, Rugang

“…CARM1 is an arginine methyltransferase that asymmetrically dimethylates protein substrates on arginine residues. CARM1 is often overexpressed in human cancers…”
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BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer by Yokoyama, Yuhki, Zhu, Hengrui, Lee, Jeong Heon, Kossenkov, Andrew V, Wu, Sherry Y, Wickramasinghe, Jayamanna M, Yin, Xiangfan, Palozola, Katherine C, Gardini, Alessandro, Showe, Louise C, Zaret, Kenneth S, Liu, Qin, Speicher, David, Conejo-Garcia, Jose R, Bradner, James E, Zhang, Zhiguo, Sood, Anil K, Ordog, Tamas, Bitler, Benjamin G, Zhang, Rugang

“…The emergence of tumor cells with certain stem-like characteristics, such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 expression, contributes…”
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The Impact of Wind-Driven Rain on Surface Waterproofed Brick Cavity Walls by D’Ayala, Dina, Zhu, Hengrui, Aktas, Yasemin

“…Moisture ingress is a major cause of damage to masonry cavity walls. Products of various chemical compositions are available for wall surface treatment, aimed…”
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Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway by Tang, Lisha, Zhu, Hengrui, Yang, Xianmei, Xie, Fang, Peng, Jingtao, Jiang, Deke, Xie, Jun, Qi, Meiyan, Yu, Long

“…Natural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer,…”
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FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia by Fang, Douglas D., Zhu, Hengrui, Tang, Qiuqiong, Wang, Guangfeng, Min, Ping, Wang, Qixin, Li, Na, Yang, Dajun, Zhai, Yifan

“…FLT3-ITD mutations occur in approximately 25% of patients with acute myeloid leukemia (AML) and are associated with poor prognosis. Despite initial efficacy,…”
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SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase by Zhu, Hengrui, Ren, Shancheng, Bitler, Benjamin G., Aird, Katherine M., Tu, Zhigang, Skordalakes, Emmanuel, Zhu, Yasheng, Yan, Jun, Sun, Yinghao, Zhang, Rugang

“…The SPOP gene, which encodes an E3 ubiquitin ligase adaptor, is frequently mutated in a number of cancer types. However, the mechanisms by which SPOP functions…”
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Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells by Zhu, Hengrui, Liu, Zulong, Tang, Lisha, Liu, Junhua, Zhou, Mei, Xie, Fang, Wang, Zheng, Wang, Yuqi, Shen, Sida, Hu, Lihong, Yu, Long

“…Multidrug resistance (MDR) to anticancer drugs is a major obstacle to successful chemotherapy in the treatment of cancers. Identification of natural compounds…”
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N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance by Fukumoto, Takeshi, Zhu, Hengrui, Nacarelli, Timothy, Karakashev, Sergey, Fatkhutdinov, Nail, Wu, Shuai, Liu, Pingyu, Kossenkov, Andrew V., Showe, Louise C., Jean, Stephanie, Zhang, Lin, Zhang, Rugang

“…Abstract Despite the high initial response rates to PARP inhibitors (PARPi) in BRCA-mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major…”
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Probing the Local Interstellar Medium with Scintillometry of the Bright Pulsar B1133 + 16 by McKee, James W., Zhu, Hengrui, Stinebring, Daniel R., Cordes, James M.

“…Abstract The interstellar medium hosts a population of scattering screens, most of unknown origin. Scintillation studies of pulsars provide a sensitive tool…”
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N 6 -Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance by Fukumoto, Takeshi, Zhu, Hengrui, Nacarelli, Timothy, Karakashev, Sergey, Fatkhutdinov, Nail, Wu, Shuai, Liu, Pingyu, Kossenkov, Andrew V, Showe, Louise C, Jean, Stephanie, Zhang, Lin, Zhang, Rugang

“…Despite the high initial response rates to PARP inhibitors (PARPi) in -mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major challenge…”
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Tectonic and magmatic evolution of the southernmost Mariana convergent margin: Constraints from geochronology and geochemistry of the Challenger Deep sediments by Yang, Ming, Wu, Tao, Zhang, Wen, Tian, Liyan, Lu, Jianggu, Song, Taoran, Zhu, Hengrui, Hong, Yidi, Chen, Jiawang

“…The southernmost Mariana convergent margin (SMCM) is a distinct segment of the Izu-Bonin-Mariana (IBM) subduction system with unique east-west orientation,…”
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Scintillation Arcs in Pulsar B0450-18 by Rickett, Barney J., Stinebring, Dan R., Zhu, Hengrui, Minter, Anthony H.

“…We report on Green Bank Telescope observations of interstellar scintillation from the pulsar B0450−18 at 340 and 825 MHz, revealing prominent arcs in the…”
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SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells by Stephen, Tom L., Payne, Kyle K., Chaurio, Ricardo A., Allegrezza, Michael J., Zhu, Hengrui, Perez-Sanz, Jairo, Perales-Puchalt, Alfredo, Nguyen, Jenny M., Vara-Ailor, Ana E., Eruslanov, Evgeniy B., Borowsky, Mark E., Zhang, Rugang, Laufer, Terri M., Conejo-Garcia, Jose R.

“…Despite the importance of programmed cell death-1 (PD-1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly…”
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Beyond immune suppression: the intrinsic function of PD-L1 in ovarian cancer and melanoma by Zhu, Hengrui, Zhang, Rugang

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Abstract 1096: FMS-like tyrosine kinase 3 (FLT3) inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor APG-2575 in preclinical models of FLT3-mutant acute myeloid leukemia (AML) by Fang, Douglas D., Zhu, Hengrui, Tang, Qiuqiong, Wang, Qixin, Li, Na, Fang, Xu, Min, Ping, Wang, Guangfeng, Yang, Dajun, Zhai, Yifan

“…Abstract AML accounts for 80% of acute leukemias in adults. FLT3 gene mutations are observed in approximately 30% of patients with AML and augur a poor…”
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