Search Results - "Zhu, Helen H."

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis by Bard-Chapeau, Emilie A., Li, Shuangwei, Ding, Jin, Zhang, Sharon S., Zhu, Helen H., Princen, Frederic, Fang, Diane D., Han, Tao, Bailly-Maitre, Beatrice, Poli, Valeria, Varki, Nissi M., Wang, Hongyang, Feng, Gen-Sheng

“…The human gene Ptpn11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in…”
Get full text

Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis by Li, Shuangwei, Hsu, Diane D.F., Li, Bing, Luo, Xiaolin, Alderson, Nazilla, Qiao, Liping, Ma, Lina, Zhu, Helen H., He, Zhao, Suino-Powell, Kelly, Ji, Kaihong, Li, Jiefu, Shao, Jianhua, Xu, H. Eric, Li, Tiangang, Feng, Gen-Sheng

“…Bile acid (BA) biosynthesis is tightly controlled by intrahepatic negative feedback signaling elicited by BA binding to farnesoid X receptor (FXR) and also by…”
Get full text

Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals by He, Zhao, Zhang, Sharon S., Meng, Qingyuan, Li, Shuangwei, Zhu, Helen H., Raquil, Marie-Astrid, Alderson, Nazilla, Zhang, Hai, Wu, Jiarui, Rui, Liangyou, Cai, Dongsheng, Feng, Gen-Sheng

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase by He, Zhao, Zhu, Helen H, Bauler, Timothy J, Wang, Jing, Ciaraldi, Theodore, Alderson, Nazilla, Li, Shuangwei, Raquil, Marie-Astrid, Ji, Kaihong, Wang, Shufen, Shao, Jianhua, Henry, Robert R, King, Philip D, Feng, Gen-Sheng

“…The molecular mechanism underlying adipogenesis and the physiological functions of adipose tissue are not fully understood. We describe here a unique mouse…”
Get full text

T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for cancer immunotherapy by Zhai, Yihui, Wang, Jinming, Lang, Tianqun, Kong, Ying, Rong, Rong, Cai, Ying, Ran, Wei, Xiong, Fengqin, Zheng, Chao, Wang, Yanke, Yu, Yang, Zhu, Helen H., Zhang, Pengcheng, Li, Yaping

“…Impaired type I interferons (IFNs) may cause immune deficiency in tumours. Current supplementary IFN therapy partially restores anticancer immunity but…”
Get full text

Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy by Cai, Ying, Zheng, Chao, Xiong, Fengqin, Ran, Wei, Zhai, Yihui, Zhu, Helen H., Wang, Hao, Li, Yaping, Zhang, Pengcheng

“…Supramolecular peptide hydrogel (SPH) is a class of biomaterials self‐assembled from peptide‐based gelators through non‐covalent interactions. Among many of…”
Get full text

Modulation of Fatty Acid Synthase Degradation by Concerted Action of p38 MAP Kinase, E3 Ligase COP1, and SH2-Tyrosine Phosphatase Shp2 by Yu, Jianxiu, Deng, Rong, Zhu, Helen H., Zhang, Sharon S., Zhu, Changhong, Montminy, Marc, Davis, Roger, Feng, Gen-Sheng

“…The Src-homology 2 (SH2) domain-containing tyrosine phosphatase Shp2 has been known to regulate various signaling pathways triggered by receptor and…”
Get full text

A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation by Huang, Hui, Woo, Andrew J, Waldon, Zachary, Schindler, Yocheved, Moran, Tyler B, Zhu, Helen H, Feng, Gen-Sheng, Steen, Hanno, Cantor, Alan B

“…Hematopoietic development occurs in complex microenvironments and is influenced by key signaling events. Yet how these pathways communicate with master…”
Get full text

SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells by McPherson, Victor A, Sharma, Namit, Everingham, Stephanie, Smith, Julie, Zhu, Helen H, Feng, Gen-Sheng, Craig, Andrew W B

“…Clustering of the high affinity IgE receptor (Fc(epsilon)RI) in mast cells leads to degranulation and production of numerous cytokines and lipid mediators that…”
Get full text

High-density lipoprotein modulates tumor-associated macrophage for chemoimmunotherapy of hepatocellular carcinoma by Wang, Junyang, Zheng, Chao, Zhai, Yihui, Cai, Ying, Lee, Robert J., Xing, Jianming, Wang, Hao, Zhu, Helen H., Teng, Lesheng, Li, Yaping, Zhang, Pengcheng

“…Intratumoral abundance of alternatively activated macrophages (M2) in hepatocellular carcinoma (HCC) is associated with advanced stages, poor prognosis and…”
Get full text

Abstract 473: TRIM59, a novel prognostic marker for gastric cancer, promotes tumorigenesis via ubiquitination and degradation of the p53 tumor suppressor by Zhou, Zhicheng, Wang, You, Li, Jian, Cao, Hui, Zhu, Helen H., Gao, Wei-Qiang

“…As a key tumor suppressor, p53 plays crucial roles in gastric cancer initiation and progression. However, the underlying mechanisms for the down-regulation of…”
Get full text

Abstract 23: Microrna302-367 Sphingosine 1 Phosphate Receptor 1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Enhancing Vascular Stability by Pi, Jinjiang, Tao, Ting, Zhuang, Tao, Sun, Huimin, Chen, Xiaoli, Shen, Yixin, Yu, Zuoren, Zhu, Helen H, Gao, Wei-qiang, Suo, Yuanzhen, Wei, Xunbin, Zheng, Xiangjian, Tian, Ying, Morrisey, Edward, Zhang, Lin, Zhang, Yuzhen

“…Abstract only Angiogenic hypersprouting and leaky immature vessels of pathological angiogenesis are essential for tumor growth. MicroRNAs have unique…”
Get full text

SHP-2 Mediates C-type Lectin Receptors-induced Syk Activation and Anti-fungal TH17 Responses by Deng, Zihou, Ma, Shixin, Zhou, Hao, Zang, Aiping, Fang, Yiyuan, Li, Tiantian, Shi, Huanjing, Liu, Mei, Du, Min, Taylor, Patricia R., Zhu, Helen H., Chen, Jiangye, Meng, Guangxun, Li, Fubin, Chen, Changbin, Zhang, Yan, Jia, Xin-Ming, Lin, Xin, Zhang, Xiaoming, Pearlman, Eric, Li, Xiaoxia, Feng, Gen-Sheng, Xiao, Hui

“…Fungal infection stimulates the canonical C-type lectin receptors (CLRs) signaling pathway via Syk activation. Here we show that SHP-2 plays a crucial role in…”
Get full text

Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase by He, Zhao, Zhu, Helen H., Bauler, Timothy J., Wang, Jing, Ciaraldi, Theodore, Alderson, Nazilla, Li, Shuangwei, Raquil, Marie-Astrid, Ji, Kaihong, Wang, Shufen, Shao, Jianhua, Henry, Robert R., King, Philip D., Feng, Gen-Sheng

Get full text

Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool by Zhu, Helen He, Ji, Kaihong, Alderson, Nazilla, He, Zhao, Li, Shuangwei, Liu, Wen, Zhang, Dong-Er, Li, Linheng, Feng, Gen-Sheng

“…The stem cell factor (SCF)/Kit system has served as a classic model in deciphering molecular signaling events in the hematopoietic compartment, and Kit…”
Get full text

SH2 Domain-Containing Phosphatase-2 Protein-Tyrosine Phosphatase Promotes Fc{epsilon}RI-Induced Activation of Fyn and Erk Pathways Leading to TNF{alpha} Release from Bone Marrow-Derived Mast Cells by McPherson, Victor A, Sharma, Namit, Everingham, Stephanie, Smith, Julie, Zhu, Helen H, Feng, Gen-Sheng, Craig, Andrew W. B

Get full text