Search Results - "Zhu, Alan Jian"

Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models by Wang, Yao, Zhou, Jiaxin, Yang, Qi, Li, Xinmeng, Qiu, Yifu, Zhang, Yansong, Liu, Min, Zhu, Alan Jian

“…Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide. If left untreated, MASLD can progress…”
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Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle by Zhao, Wanni, Zhang, Yansong, Lin, Siyuan, Li, Yajuan, Zhu, Alan Jian, Shi, Hanping, Liu, Min

“…Background Malnutrition is implicated in human metabolic disorders, including hepatic steatosis and myosteatosis. The corresponding nutrient signals and…”
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Stuxnet Facilitates the Degradation of Polycomb Protein during Development by Du, Juan, Zhang, Junzheng, He, Tao, Li, Yajuan, Su, Ying, Tie, Feng, Liu, Min, Harte, Peter J., Zhu, Alan Jian

“…Polycomb-group (PcG) proteins function to ensure correct deployment of developmental programs by epigenetically repressing target gene expression. Despite the…”
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Ubpy controls the stability of the ESCRT-0 subunit Hrs in development by Zhang, Junzheng, Du, Juan, Lei, Cong, Liu, Min, Zhu, Alan Jian

“…Ubiquitylated developmental membrane signaling proteins are often internalized for endocytic trafficking, through which endosomal sorting complexes required…”
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Dissection of the microRNA Network Regulating Hedgehog Signaling in Drosophila by He, Tao, Fan, Yu, Wang, Yao, Liu, Min, Zhu, Alan Jian

“…The evolutionarily conserved Hedgehog (Hh) signaling plays a critical role in embryogenesis and adult tissue homeostasis. Aberrant Hh signaling often leads to…”
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Signaling via β1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro by Zhu, Alan Jian, Haase, Ingo, Watt, Fiona M.

“…Human epidermal stem cells express higher levels of β1 integrins and are more adhesive than keratinocytes that are destined to differentiate. To investigate…”
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Incredible journey: how do developmental signals travel through tissue? by Zhu, Alan Jian, Scott, Matthew P

“…How developmental signaling proteins traverse tissue during animal development, through or around tightly packed cells, remains an incompletely resolved…”
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The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development by Liu, Min, Li, Yajuan, Liu, Aiguo, Li, Ruifeng, Su, Ying, Du, Juan, Li, Cheng, Zhu, Alan Jian

“…Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for…”
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In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling by Du, Juan, Zhang, Junzheng, Su, Ying, Liu, Min, Ospina, Jason K, Yang, Shengyuan, Zhu, Alan Jian

“…Hedgehog (Hh) signaling is highly conserved in all metazoan animals and plays critical roles in many developmental processes. Dysregulation of the Hh signaling…”
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Protein modifications in Hedgehog signaling: Cross talk and feedback regulation confer divergent Hedgehog signaling activity by Liu, Min, Su, Ying, Peng, Jingyu, Zhu, Alan Jian

“…The complexity of the Hedgehog (Hh) signaling cascade has increased over the course of evolution; however, it does not suffice to accommodate the dynamic yet…”
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Protein modifications in Hedgehog signaling by Liu, Min, Su, Ying, Peng, Jingyu, Zhu, Alan Jian

“…The complexity of the Hedgehog (Hh) signaling cascade has increased over the course of evolution; however, it does not suffice to accommodate the dynamic yet…”
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Stuxnet fine-tunes Notch dose during development using a functional Polycomb response element by He, Tao, Fan, Yu, Du, Juan, Yi, Mengyuan, Li, Yajuan, Liu, Min, Zhu, Alan Jian

“…Evolutionarily conserved Notch signaling is highly sensitive to changes in Notch receptor dose caused by intrinsic and environmental fluctuations. It is well…”
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Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes by Gao, Yuan, Feng, Jing, Zhang, Yansong, Yi, Mengyuan, Zhang, Lebing, Yan, Yan, Zhu, Alan Jian, Liu, Min

“…Wingless (Wg)/Wnt signaling plays a critical role in both development and adult tissue homeostasis. In the Drosophila larval wing disc epithelium, the orderly…”
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Competition between two phosphatases fine-tunes Hedgehog signaling by Liu, Min, Liu, Aiguo, Wang, Jie, Zhang, Yansong, Li, Yajuan, Su, Ying, Zhu, Alan Jian

“…Hedgehog (Hh) signaling is essential for embryonic development and adult homeostasis. How its signaling activity is fine-tuned in response to fluctuated Hh…”
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Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination by Zhang, Yansong, Lin, Siyuan, Peng, Jingyu, Liang, Xiaojuan, Yang, Qi, Bai, Xue, Li, Yajuan, Li, Jinhua, Dong, Wei, Wang, Yue, Huang, Ying, Pei, Yumeng, Guo, Jiabao, Zhao, Wanni, Zhang, Zhe, Liu, Min, Zhu, Alan Jian

“…Nonalcoholic fatty liver disease (NAFLD) is a global health concern with no approved drugs. High-protein dietary intervention is currently the most effective…”
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Stuxnet fine-tunes Notch dose during development with a functional Polycomb response element by He, Tao, Fan, Yu, Du, Juan, Yi, Mengyuan, Li, Yajuan, Liu, Min, Zhu, Alan Jian

“…Evolutionarily conserved Notch signaling is highly sensitive to changes in Notch receptor dose caused by intrinsic and environmental fluctuations. It is well…”
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Sequential phosphorylation of smoothened transduces graded hedgehog signaling by Su, Ying, Ospina, Jason K, Zhang, Junzheng, Michelson, Andrew P, Schoen, Adam M, Zhu, Alan Jian

“…The correct interpretation of a gradient of the morphogen Hedgehog (Hh) during development requires phosphorylation of the Hh signaling activator Smoothened…”
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A widely diverged locus involved in locomotor adaptation in Heliconius butterflies by Zhang, Yubo, Teng, Dequn, Lu, Wei, Liu, Min, Zeng, Hua, Cao, Lei, Southcott, Laura, Potdar, Sushant, Westerman, Erica, Zhu, Alan Jian, Zhang, Wei

“…A locomotor locus shows high divergence and signatures of introgression among Heliconius butterflies. Heliconius butterflies have undergone adaptive radiation…”
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A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling by Zhang, Junzheng, Liu, Min, Su, Ying, Du, Juan, Zhu, Alan Jian

“…Notch signaling is highly conserved in all metazoan animals and plays critical roles in cell fate specification, cell proliferation, apoptosis, and stem cell…”
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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction by Zhu, Alan Jian, Zheng, Limin, Suyama, Kaye, Scott, Matthew P

“…Hedgehog (Hh) signaling is critical for many developmental events and must be restrained to prevent cancer. A transmembrane protein, Smoothened (Smo), is…”
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