Search Results - "Zhou, Zhengfeng"

Plastic damage analysis of concrete around misaligned dowel bar in jointed concrete pavement by Mohammed, Ibrahim, Zhengfeng, Zhou, Changfa, Ai

“…Dowel bar misalignment causes stress concentration in jointed concrete pavements, and misaligned dowel bars may lose their ability to transfer loads. To…”
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Evaluating the impact of temperature variations and subgrade reactions under traffic-load on airport concrete pavement performance by Mohammed, Ibrahim, Zhengfeng, Zhou, Changfa, AI

“…This study delves into the intricate dynamics of airport concrete pavement slabs under the influence of temperature fluctuations and traffic loads. It presents…”
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Brief Report: Oxidative Stress Mediates Cardiomyocyte Apoptosis in a Human Model of Danon Disease and Heart Failure by Hashem, Sherin I., Perry, Cynthia N., Bauer, Matthieu, Han, Sangyoon, Clegg, Stacey D., Ouyang, Kunfu, Deacon, Dekker C., Spinharney, Mary, Panopoulos, Athanasia D., Izpisua Belmonte, Juan Carlos, Frazer, Kelly A., Chen, Ju, Gong, Qiuming, Zhou, Zhengfeng, Chi, Neil C., Adler, Eric D.

“…Danon disease is a familial cardiomyopathy associated with impaired autophagy due to mutations in the gene encoding lysosomal‐associated membrane protein type…”
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Regulation of Kv11.1 Isoform Expression by Polyadenylate Binding Protein Nuclear 1 by Stump, Matthew R, Nguyen, Rachel T, Drgastin, Rachel H, Search, Delaney, Gong, Qiuming, Zhou, Zhengfeng

“…The Kv11.1 voltage-gated potassium channel, encoded by the KCNH2 gene, conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA…”
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Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome by Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng

“…The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC) mutations by nonsense-mediated mRNA…”
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Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism by ANDERSON, Corey L, DELISLE, Brian P, ANSON, Blake D, KILBY, Jennifer A, WILL, Melissa L, TESTER, David J, QIUMING GONG, ZHENGFENG ZHOU, ACKERMAN, Michael J, JANUARY, Craig T

“…The KCNH2 or human ether-a-go-go related gene (hERG) encodes the Kv11.1 alpha-subunit of the rapidly activating delayed rectifier K+ current (IKr) in the…”
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Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mrna decay in human long-QT syndrome by QIUMING GONG, LI ZHANG, VINCENT, G. Michael, HOME, Benjamin D, ZHENGFENG ZHOU

“…Long-QT syndrome type 2 (LQT2) is caused by mutations in the human ether-a-go-go-related gene (hERG). More than 30% of the LQT2 mutations result in premature…”
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A Major Role for hERG in Determining Frequency of Reentry in Neonatal Rat Ventricular Myocyte Monolayer by Hou, Luqia, Deo, Makarand, Furspan, Philip, Pandit, Sandeep V, Mironov, Sergey, Auerbach, David S, Gong, Qiuming, Zhou, Zhengfeng, Berenfeld, Omer, Jalife, José

“…RATIONALE:The rapid delayed rectifier potassium current, IKr, which flows through the human ether-a-go-go-related (hERG) channel, is a major determinant of the…”
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Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome by Stump, Matthew R, Gong, Qiuming, Zhou, Zhengfeng

“…Mutations in the human ether-a-go-go-related gene 1 (hERG1) cause type 2 long QT syndrome (LQT2). The hERG1 gene encodes a K(+) channel with properties similar…”
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Postmortem molecular screening in unexplained sudden death by Chugh, Sumeet S, Senashova, Olga, Watts, Allison, Tran, Phuoc T, Zhou, Zhengfeng, Gong, Qiuming, Titus, Jack L, Hayflick, Susan J

“…We examined the prevalence of defects in arrhythmia-related candidate genes among patients with unexplained sudden cardiac death (SCD). Patients with…”
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Degradation of Trafficking-defective Long QT Syndrome Type II Mutant Channels by the Ubiquitin-Proteasome Pathway by Gong, Qiuming, Keeney, David R., Molinari, Maurizio, Zhou, Zhengfeng

“…Mutations in the human ether-a-go-go-related gene (hERG) cause chromosome 7-linked long QT syndrome type II (LQT2). We have shown previously that LQT2…”
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Mechanisms of Pharmacological Rescue of Trafficking-defective hERG Mutant Channels in Human Long QT Syndrome by Gong, Qiuming, Jones, Melanie A., Zhou, Zhengfeng

“…Long QT syndrome type 2 is caused by mutations in the human ether-a-go-go-related gene (hERG). We previously reported that the N470D mutation is retained in…”
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Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation by Bhuiyan, Zahurul A., MD, PhD, Momenah, Tarek S., MD, FACC, Gong, Qiuming, MD, PhD, Amin, Ahmad S., MD, Ghamdi, Saleh Al, MD, Carvalho, Julene S., MD, PhD, Homfray, Tessa, MD, MRCP, Mannens, Marcel M.A.M., PhD, Zhou, Zhengfeng, MD, PhD, Wilde, Arthur A.M., MD, PhD

“…Background Inherited arrhythmias may underlie intrauterine and neonatal arrhythmias. Resolving the molecular genetic nature of these rare cases provides…”
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Properties of HERG Channels Stably Expressed in HEK 293 Cells Studied at Physiological Temperature by Zhou, Zhengfeng, Gong, Qiuming, Ye, Bin, Fan, Zheng, Makielski, Jonathan C., Robertson, Gail A., January, Craig T.

“…We have established stably transfected HEK 293 cell lines expressing high levels of functional human ether-a go-go-related gene (HERG) channels. We used these…”
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Mechanism of Block and Identification of the Verapamil Binding Domain to HERG Potassium Channels by Zhang, Shetuan, Zhou, Zhengfeng, Gong, Qiuming, Makielski, Jonathan C, January, Craig T

“…Calcium channel antagonists have diverse effects on cardiac electrophysiology. We studied the effects of verapamil, diltiazem, and nifedipine on HERG K…”
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Nonsense-mediated mRNA decay caused by a frameshift mutation in a large kindred of type 2 long QT syndrome by Zarraga, Ignatius Gerardo, MD, Zhang, Li, MD, Stump, Matthew R., PhD, Gong, Qiuming, MD, PhD, Vincent, G. Michael, MD, Zhou, Zhengfeng, MD, PhD

“…Background Nonsense and frameshift mutations are common in congenital long QT syndrome type 2 (LQT2). We previously demonstrated that hERG nonsense mutations…”
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Role of glycosylation in cell surface expression and stability of HERG potassium channels by Gong, Qiuming, Anderson, Corey L, January, Craig T, Zhou, Zhengfeng

“…The human ether-à-go-go-related gene (HERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel in the heart. We…”
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Block of HERG Potassium Channels by the Antihistamine Astemizole and its Metabolites Desmethylastemizole and Norastemizole by ZHOU, ZHENGFENG, VORPERIAN, VICKEN R., GONG, QIUMING, ZHANG, SHETUAN, JANUARY, CRAIG T.

“…Electrophysiologic Effects of Astemizole Metabolites. Introduction: The selective H1‐receptor antagonist astemizole (Hismanal) causes acquired long QT…”
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Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride by Mohammad, S, Zhou, Z, Gong, Q, January, C T

“…Cisapride, a gastrointestinal prokinetic agent, is known to cause long Q-T syndrome and ventricular arrhythmias. The cellular mechanism is not known. The human…”
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Mesoscale fracture analysis of three-point bending concrete beams based on cohesive zone model by Zhu, Shangshu, Zhou, Zhengfeng, Xiong, Yang

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