Search Results - "Zhou, Z Hong"

Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes by Dai, Xinghong, Zhou, Z Hong

“…Herpes simplex viruses (HSVs) rely on capsid-associated tegument complex (CATC) for long-range axonal transport of their genome-containing capsids between…”
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Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel by Li, Binsen, Ge, Peng, Murray, Kevin A., Sheth, Phorum, Zhang, Meng, Nair, Gayatri, Sawaya, Michael R., Shin, Woo Shik, Boyer, David R., Ye, Shulin, Eisenberg, David S., Zhou, Z. Hong, Jiang, Lin

“…α-Synuclein (aSyn) fibrillar polymorphs have distinct in vitro and in vivo seeding activities, contributing differently to synucleinopathies. Despite numerous…”
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Atomic structure of anthrax protective antigen pore elucidates toxin translocation by Jiang, Jiansen, Pentelute, Bradley L., Collier, R. John, Zhou, Z. Hong

“…Cryo-electron microscopy determination of anthrax toxin protective antigen pore structure at a resolution of 2.9 Å, revealing the catalytic Φ-clamp and the…”
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Malaria parasite translocon structure and mechanism of effector export by Ho, Chi-Min, Beck, Josh R., Lai, Mason, Cui, Yanxiang, Goldberg, Daniel E., Egea, Pascal F., Zhou, Z. Hong

“…The putative Plasmodium translocon of exported proteins (PTEX) is essential for transport of malarial effector proteins across a parasite-encasing vacuolar…”
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Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150 by Yu, Xuekui, Jih, Jonathan, Jiang, Jiansen, Zhou, Z. Hong

“…Herpesviruses possess a genome-pressurized capsid. The 235-kilobase genome of human cytomegalovirus (HCMV) is by far the largest of any herpesvirus, yet it has…”
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Cryo-EM structure of the mature dengue virus at 3.5-Å resolution by Zhang, Xiaokang, Ge, Peng, Yu, Xuekui, Brannan, Jennifer M, Bi, Guoqiang, Zhang, Qinfen, Schein, Stan, Zhou, Z Hong

“…Dengue virus has two membrane proteins, E and M, which undergo dramatic structural changes during the life cycle of the virus. The 3.5-Å cryo-EM structure of…”
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Structures and operating principles of the replisome by Gao, Yang, Cui, Yanxiang, Fox, Tara, Lin, Shiqiang, Wang, Huaibin, de Val, Natalia, Zhou, Z Hong, Yang, Wei

“…Visualization in atomic detail of the replisome that performs concerted leading- and lagging-DNA strand synthesis at a replication fork has not been reported…”
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Encapsulation state of messenger RNA inside lipid nanoparticles by Brader, Mark L., Williams, Sean J., Banks, Jessica M., Hui, Wong H., Zhou, Z. Hong, Jin, Lin

“…Understanding the structure of messenger RNA (mRNA) lipid nanoparticles, and specifically the microenvironment of the mRNA molecules within these entities, is…”
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Differentiation and Characterization of Excitatory and Inhibitory Synapses by Cryo-electron Tomography and Correlative Microscopy by Tao, Chang-Lu, Liu, Yun-Tao, Sun, Rong, Zhang, Bin, Qi, Lei, Shivakoti, Sakar, Tian, Chong-Li, Zhang, Peijun, Lau, Pak-Ming, Zhou, Z Hong, Bi, Guo-Qiang

“…As key functional units in neural circuits, different types of neuronal synapses play distinct roles in brain information processing, learning, and memory…”
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Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu by Ho, Chi-Min, Li, Xiaorun, Lai, Mason, Terwilliger, Thomas C., Beck, Josh R., Wohlschlegel, James, Goldberg, Daniel E., Fitzpatrick, Anthony W. P., Zhou, Z. Hong

“…X-ray crystallography often requires non-native constructs involving mutations or truncations, and is challenged by membrane proteins and large multicomponent…”
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In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus by Zhang, Xing, Ding, Ke, Yu, Xuekui, Chang, Winston, Sun, Jingchen, Hong Zhou, Z.

“…This study visualizes the interior of a dsRNA virus using cryo-electron microscopy, revealing the organization of the genome of cytoplasmic polyhedrosis virus…”
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Isotropic reconstruction for electron tomography with deep learning by Liu, Yun-Tao, Zhang, Heng, Wang, Hui, Tao, Chang-Lu, Bi, Guo-Qiang, Zhou, Z. Hong

“…Cryogenic electron tomography (cryoET) allows visualization of cellular structures in situ. However, anisotropic resolution arising from the intrinsic…”
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In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus by Dai, Xinghong, Li, Zhihai, Lai, Mason, Shu, Sara, Du, Yushen, Zhou, Z. Hong, Sun, Ren

“…A high-resolution structure of the bacteriophage MS2 sheds light on the structure of the genome and how the genome is delivered into a bacterium. Atomic…”
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Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2 by Guenther, Elizabeth L., Ge, Peng, Trinh, Hamilton, Sawaya, Michael R., Cascio, Duilio, Boyer, David R., Gonen, Tamir, Zhou, Z. Hong, Eisenberg, David S.

“…Proteins in the fibrous amyloid state are a major hallmark of neurodegenerative disease. Understanding the multiple conformations, or polymorphs, of amyloid…”
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A unified mechanism for intron and exon definition and back-splicing by Li, Xueni, Liu, Shiheng, Zhang, Lingdi, Issaian, Aaron, Hill, Ryan C., Espinosa, Sara, Shi, Shasha, Cui, Yanxiang, Kappel, Kalli, Das, Rhiju, Hansen, Kirk C., Zhou, Z. Hong, Zhao, Rui

“…The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron…”
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Conservative transcription in three steps visualized in a double-stranded RNA virus by Cui, Yanxiang, Zhang, Yinong, Zhou, Kang, Sun, Jingchen, Zhou, Z. Hong

“…Endogenous RNA transcription characterizes double-stranded RNA (dsRNA) viruses in the Reoviridae , a family that is exemplified by its simple, single-shelled…”
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Structure of the yeast spliceosomal postcatalytic P complex by Liu, Shiheng, Li, Xueni, Zhang, Lingdi, Jiang, Jiansen, Hill, Ryan C., Cui, Yanxiang, Hansen, Kirk C., Zhou, Z. Hong, Zhao, Rui

“…The spliceosome undergoes dramatic changes in a splicing cycle. Structures of B, Bact, C, C*, and intron lariat spliceosome complexes revealed mechanisms of…”
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Multiple conformations of trimeric spikes visualized on a non-enveloped virus by Zhang, Yinong, Cui, Yanxiang, Sun, Jingchen, Zhou, Z. Hong

“…Many viruses utilize trimeric spikes to gain entry into host cells. However, without in situ structures of these trimeric spikes, a full understanding of this…”
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CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1 by Huynh, Kevin W., Jiang, Jiansen, Abuladze, Natalia, Tsirulnikov, Kirill, Kao, Liyo, Shao, Xuesi, Newman, Debra, Azimov, Rustam, Pushkin, Alexander, Zhou, Z. Hong, Kurtz, Ira

“…Na + -coupled acid–base transporters play essential roles in human biology. Their dysfunction has been linked to cancer, heart, and brain disease…”
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Towards atomic resolution structural determination by single-particle cryo-electron microscopy by Zhou, Z Hong

“…Recent advances in cryo-electron microscopy and single-particle reconstruction (collectively referred to as ‘cryoEM’) have made it possible to determine the…”
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