Search Results - "Zhou, You Lang"

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer by Zhang, Bo, Wu, Qiong, Li, Ben, Wang, Defeng, Wang, Lei, Zhou, You Lang

“…Abstract Background The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA…”
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Sensitization of P2X3 receptors by cystathionine β-synthetase mediates persistent pain hypersensitivity in a rat model of lumbar disc herniation by Wang, Qianliang, Zhu, Hongyan, Zou, Kang, Yuan, Bo, Zhou, You-Lang, Jiang, Xinghong, Yan, Jun, Xu, Guang-Yin

“…Lumbar disc herniation (LDH) is a major cause of discogenic low back pain and sciatica, but the underlying mechanisms remain largely unknown. Hydrogen sulfide…”
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Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats by Wei, Jinrong, Li, Meng, Wang, Dieyu, Zhu, Hongyan, Kong, Xiangpeng, Wang, Shusheng, Zhou, You-Lang, Ju, Zhong, Xu, Guang-Yin, Jiang, Guo-Qin

“…Background Cancer-induced pain (CIP) is one of the most severe types of chronic pain with which clinical treatment remains challenging and the involved…”
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Macrophages regulated by cyclooxygenases promote tendon healing via Pla1a/Etv1 axis by Jing, Jin, Qian Qian, Yang, Jie, Sun, You Lang, Zhou

“…[Display omitted] •Inflammation response plays a significant role in tendon healing.•Cyclooxygenase promote tendon healing via macrophage…”
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Immune-related adverse events from combination immunotherapy in cancer patients: A comprehensive meta-analysis of randomized controlled trials by Zhang, Bo, Wu, Qiong, Zhou, You Lang, Guo, Xinyu, Ge, Jun, Fu, Jiaji

“…Although available evidence from clinical trials has shown that immune checkpoint inhibitors (ICIs) combination therapy can lead to a series of immune-related…”
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Effectiveness of MicroRNA in Down-Regulation of TGF-β Gene Expression in Digital Flexor Tendons of Chickens: In Vitro and In Vivo Study by Chen, Chuan Hao, MD, Zhou, You Lang, MS, Wu, Ya Fang, MD, Cao, Yi, MD, Gao, Jin Song, MD, Tang, Jin Bo, MD

“…Purpose Transforming growth factor (TGF)-β is considered to be responsible for the formation of scars such as adhesions around healing digital flexor tendons…”
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Gene-Loaded Nanoparticle-Coated Sutures Provide Effective Gene Delivery to Enhance Tendon Healing by Zhou, You Lang, Yang, Qian Qian, Yan, Ying Ying, Zhang, Luzhong, Wang, Qiu Hong, Ju, Fei, Tang, Jin Bo

“…How to accelerate tendon healing remains a clinical challenge. In this study, a suture carrying nanoparticle/pEGFP-basic fibroblast growth factor (bFGF) and…”
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Targeting voltage-gated sodium channels for treatment for chronic visceral pain by Qi, Fei-Hu, Zhou, You-Lang, Xu, Guang-Yin

“…Voltage-gated sodium channels （VGSCs） play a fundamental role in controlling cellular excitability,and their abnormal activity is related to several…”
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Cellular Apoptosis and Proliferation in the Middle and Late Intrasynovial Tendon Healing Periods by Wu, Ya Fang, MD, Zhou, You Lang, MS, Mao, Wei Feng, MD, Avanessian, Bella, MD, Liu, Paul Y., MD, Tang, Jin Bo, MD

“…Purpose Cellular apoptosis might be an important molecular event in the middle or late healing periods of intrasynovial tendons, but this has not been studied…”
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M2 Macrophage Membrane‐Mediated Biomimetic‐Nanoparticle Carrying COX‐siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation by Sun, Jie, Ju, Fei, Jin, Jing, Wang, Hao Liang, Li, Zhi Jie, Sun, Yu Cheng, Chen, Qing Zhong, Yang, Qian Qian, Tan, Jun, Zhou, You Lang

“…Tendon adhesion is the most common outcome of tendon or tendon‐to‐bone healing after injury. Our group developed a hydrogel‐nanoparticle sustained‐release…”
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Non-Viral Delivery of Gene Therapy to the Tendon by Jin, Jing, Yang, Qian Qian, Zhou, You Lang

“…The tendon, as a compact connective tissue, is difficult to treat after an acute laceration or chronic degeneration. Gene-based therapy is a highly efficient…”
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Localized delivery of miRNAs targets cyclooxygenases and reduces flexor tendon adhesions by Zhou, You Lang, Yang, Qian Qian, Yan, Ying Ying, Zhu, Changlai, Zhang, Luzhong, Tang, Jin Bo

“…[Display omitted] The formation of adhesions during healing of an injured tendon remains a difficult problem in clinical practice. Local anti-inflammation gene…”
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Therapeutic strategies for flexor tendon healing by nanoparticle-mediated co-delivery of bFGF and VEGFA genes by Yang, Qian Qian, Shao, Yi Xiang, Zhang, Lu Zhong, Zhou, You Lang

“…[Display omitted] •bFGF and VEGF genes were complexed with PEI-modified PLGA nanoparticles to form complexes.•Nanoparticle/gene complexes have no apparent…”
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Promoted Interaction of Nuclear Factor-κB With Demethylated Purinergic P2X3 Receptor Gene Contributes to Neuropathic Pain in Rats With Diabetes by Zhang, Hong-Hong, Hu, Ji, Zhou, You-Lang, Qin, Xin, Song, Zhen-Yuan, Yang, Pan-Pan, Hu, Shufen, Jiang, Xinghong, Xu, Guang-Yin

“…Painful diabetic neuropathy is a common complication of diabetes produced by mechanisms that as yet are incompletely defined. The aim of this study was to…”
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Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system by Jie Li, Zhi, Bing Luo, Chun, Liang Wang, Hao, Sun, Jie, Qian Yang, Qian, Lang Zhou, You

“…Tendon adhesion is one of the sequelae of tendon injury and can lead to disability in severe cases. Metformin is a commonly used antidiabetic drug. Some…”
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CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism of ceRNA and promotes the growth of malignant glioma by Huang, Xiang, Wang, Ziheng, Song, Mengruo, Huan, He, Cai, Zishu, Wu, Bing, Shen, Jianhong, Zhou, You Lang, Shi, Jinlong

“…Circular RNA (circRNA) is one of non-coding RNA with specific circular structure, which has been found to be involved in regulating a series of malignant…”
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Autophagy-related gene expression classification defines three molecular subtypes with distinct clinical and microenvironment cell infiltration characteristics in colon cancer by Zhu, Shajun, Wu, Qiong, Zhang, Bo, Wei, Huagen, Li, Ben, Shi, Wei, Fang, Miao, Zhu, Shengze, Wang, Lei, Lang Zhou, You, Dong, Yulin

“…•Three autophagy-related molecular subtypes with distinct clinical outcomes were determined in colon cancer.•Three autophagy subtypes presented significant…”
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M2 Macrophage Membrane‐Mediated Biomimetic‐Nanoparticle Carrying COX‐siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation (Small 33/2023) by Sun, Jie, Ju, Fei, Jin, Jing, Wang, Hao Liang, Li, Zhi Jie, Sun, Yu Cheng, Chen, Qing Zhong, Yang, Qian Qian, Tan, Jun, Zhou, You Lang

“…Targeted Delivery Systems Jun Tan, You Lang Zhou, and co‐workers construct successfully an M2M@PLGA/COX‐siRNA delivery system and measure its targeting…”
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The promising novel biomarkers and candidate small molecule drugs in lower‐grade glioma: Evidence from bioinformatics analysis of high‐throughput data by Zhang, Bo, Wu, Qiong, Xu, Ran, Hu, Xinyi, Sun, Yidan, Wang, Qiuhong, Ju, Fei, Ren, Shiqi, Zhang, Chenlin, Qi, Fuwei, Ma, Qianqian, Wang, Ziheng, Zhou, You Lang

“…Overall survival of patients with low‐grade glioma (LGG) has shown no significant improvement over the past 30 years, with survival averaging approximately 7…”
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Epigenetic upregulation of acid-sensing ion channel 1 contributes to gastric hypersensitivity in adult offspring rats with prenatal maternal stress by Wang, Hong-Jun, Xu, Xue, Zhang, Ping-An, Li, Meng, Zhou, You-Lang, Xu, Yu-Cheng, Jiang, Xing-Hong, Xu, Guang-Yin

“…Functional dyspepsia is a common functional gastrointestinal disorder. Gastric hypersensitivity (GHS) is a hallmark of this disorder, but the cellular…”
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