Search Results - "Zhou, Sirui"

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study by Butler-Laporte, Guillaume, Nakanishi, Tomoko, Mooser, Vincent, Morrison, David R, Abdullah, Tala, Adeleye, Olumide, Mamlouk, Noor, Kimchi, Nofar, Afrasiabi, Zaman, Rezk, Nardin, Giliberti, Annarita, Renieri, Alessandra, Chen, Yiheng, Zhou, Sirui, Forgetta, Vincenzo, Richards, J Brent

“…Increased vitamin D levels, as reflected by 25-hydroxy vitamin D (25OHD) measurements, have been proposed to protect against COVID-19 based on in vitro,…”
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Melampsora spondylitis presenting with unexplained low back pain: A case report by Zhu, Weijian, Zhou, Sirui, Xu, Zhihao, Yang, Zhiying, Zhang, Jinming

“…•Spondylitis progresses rapidly in immunocompetent than immunodeficient patients.•Repeated biopsies and routine microbiological examinations are diagnostic…”
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Individuals with common diseases but with a low polygenic risk score could be prioritized for rare variant screening by Lu, Tianyuan, Zhou, Sirui, Wu, Haoyu, Forgetta, Vincenzo, Greenwood, Celia M. T., Richards, J. Brent

“…Purpose Identifying rare genetic causes of common diseases can improve diagnostic and treatment strategies, but incurs high costs. We tested whether…”
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Machine learning-based integration develops an immunogenic cell death-derived lncRNA signature for predicting prognosis and immunotherapy response in lung adenocarcinoma by Sun, Jiazheng, Guo, Hehua, Zhang, Siyu, Nie, Yalan, Zhou, Sirui, Zeng, Yulan, Sun, Yalu

“…Accumulating evidence demonstrates that lncRNAs are involved in the regulation of the immune microenvironment and early tumor development. Immunogenic cell…”
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Deciphering the heterogeneity dominated by tumor-associated macrophages for survival prognostication and prediction of immunotherapy response in lung adenocarcinoma by Sun, Jiazheng, Guo, Hehua, Nie, Yalan, Zhou, Sirui, Zeng, Yulan, Sun, Yalu

“…Tumor-associated macrophages (TAMs) are a specific subset of macrophages that reside inside the tumor microenvironment. The dynamic interplay between TAMs and…”
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Survivin inhibition attenuates EGF-induced epithelial mesenchymal transformation of human RPE cells via the EGFR/MAPK pathway by Zhu, Yusheng, Li, Teng, Zhou, Sirui, Wang, Guowei, Zhang, Huihui, Yin, Yong, Wang, Tong, Chen, Xiaodong

“…The abnormal growth factors-induced epithelial-mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells was known as a vital pathogenesis of…”
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Unraveling the regulatory cell death pathways in gastric cancer: a multi-omics study by Sun, Jiazheng, Rao, Lixiang, Zhou, Sirui, Zeng, Yulan, Sun, Yalu

“…Gastric cancer (GC) is a prevalent form of cancer worldwide and has a high death rate, with less than 40% of patients surviving for 5 years. GC demonstrates a…”
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Progress in understanding and treating idiopathic pulmonary fibrosis: recent insights and emerging therapies by Guo, Hehua, Sun, Jiazheng, Zhang, Siyu, Nie, Yalan, Zhou, Sirui, Zeng, Yulan

“…Idiopathic pulmonary fibrosis (IPF) is a long-lasting, continuously advancing, and irrevocable interstitial lung disorder with an obscure origin and…”
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De novo variants in sporadic cases of childhood onset schizophrenia by Ambalavanan, Amirthagowri, Girard, Simon L, Ahn, Kwangmi, Zhou, Sirui, Dionne-Laporte, Alexandre, Spiegelman, Dan, Bourassa, Cynthia V, Gauthier, Julie, Hamdan, Fadi F, Xiong, Lan, Dion, Patrick A, Joober, Ridha, Rapoport, Judith, Rouleau, Guy A

“…Childhood-onset schizophrenia (COS), defined by the onset of illness before age 13 years, is a rare severe neurodevelopmental disorder of unknown etiology…”
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Increased exonic de novo mutation rate in individuals with schizophrenia by Rouleau, Guy A, Girard, Simon L, Gauthier, Julie, Noreau, Anne, Xiong, Lan, Zhou, Sirui, Jouan, Loubna, Dionne-Laporte, Alexandre, Spiegelman, Dan, Henrion, Edouard, Diallo, Ousmane, Thibodeau, Pascale, Bachand, Isabelle, Bao, Jessie Y J, Tong, Amy Hin Yan, Lin, Chi-Ho, Millet, Bruno, Jaafari, Nematollah, Joober, Ridha, Dion, Patrick A, Lok, Si, Krebs, Marie-Odile

“…Schizophrenia is a severe psychiatric disorder that profoundly affects cognitive, behavioral and emotional processes. The wide spectrum of symptoms and…”
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Alternative splicing in lung influences COVID-19 severity and respiratory diseases by Nakanishi, Tomoko, Willett, Julian, Farjoun, Yossi, Allen, Richard J., Guillen-Guio, Beatriz, Adra, Darin, Zhou, Sirui, Richards, J. Brent

“…Alternative splicing generates functional diversity in isoforms, impacting immune response to infection. Here, we evaluate the causal role of alternative…”
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Microbes for lung cancer detection: feasibility and limitations by Zhou, Sirui, Zhu, Weijian, Guo, Hehua, Nie, Yalan, Sun, Jiazheng, Liu, Ping, Zeng, Yulan

“…As the second most common cancer in the world, the development of lung cancer is closely related to factors such as heredity, environmental exposure, and lung…”
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Genetically Decreased Circulating Vascular Endothelial Growth Factor and Osteoporosis Outcomes: A Mendelian Randomization Study by Keller‐Baruch, Julyan, Forgetta, Vincenzo, Manousaki, Despoina, Zhou, Sirui, Richards, J Brent

“…ABSTRACT Vascular endothelial growth factor (VEGF) is important for bone formation and has been associated with osteoporosis in humans. Therefore, we conducted…”
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Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis by Li, Jiao, Wang, Fei, Li, Zhen, Feng, Jingjing, Men, Yi, Han, Jinming, Xia, Jiangwei, Zhang, Chen, Han, Yilai, Chen, Teng, Zhao, Yinan, Zhou, Sirui, Da, Yuwei, Chai, Guoliang, Hao, Junwei

“…Myasthenia gravis (MG) is a chronic autoimmune disorder characterized by fluctuating muscle weakness. Despite the availability of established therapies, the…”
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The effect of angiotensin-converting enzyme levels on COVID-19 susceptibility and severity: a Mendelian randomization study by Butler-Laporte, Guillaume, Nakanishi, Tomoko, Mooser, Vincent, Renieri, Alessandra, Amitrano, Sara, Zhou, Sirui, Chen, Yiheng, Forgetta, Vincenzo, Richards, J Brent

“…Abstract Background There has been uncertainty about the safety or benefit of angiotensin-converting enzyme (ACE) inhibitors during the COVID-19 pandemic. We…”
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RSPO3 is important for trabecular bone and fracture risk in mice and humans by Nilsson, Karin H., Henning, Petra, El Shahawy, Maha, Nethander, Maria, Andersen, Thomas Levin, Ejersted, Charlotte, Wu, Jianyao, Gustafsson, Karin L., Koskela, Antti, Tuukkanen, Juha, Souza, Pedro P. C., Tuckermann, Jan, Lorentzon, Mattias, Ruud, Linda Engström, Lehtimäki, Terho, Tobias, Jon H., Zhou, Sirui, Lerner, Ulf H., Richards, J. Brent, Movérare-Skrtic, Sofia, Ohlsson, Claes

“…With increasing age of the population, countries across the globe are facing a substantial increase in osteoporotic fractures. Genetic association signals for…”
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Does vitamin D supplementation improve bone health, body composition and physical performance beyond endurance exercise in patients with type 2 diabetes: A secondary analysis of randomized controlled trial by Sun, Xiaomin, Xiao, Wenjuan, Li, Zhongying, Zhou, Sirui, Dong, Mengyue, Huang, Cong, Ma, Yan, Gou, Bo

“…This study aimed to assess the effects of a 12-week vitamin D and endurance exercise intervention on bone health, body composition and physical performance…”
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Genome-Wide Identification and Characterization of the OFP Gene Family in the Wild Strawberry Fragaria vesca by Xu, Xiao, Wang, Xinyu, Zhou, Sirui, Huang, Xumo, Liu, Pengcheng, Ma, Bojun, Chen, Xifeng

“…OVATE family proteins (OFPs) are a kind of plant-specific transcription factor, which play important roles in the growth and development of plants. Here, we…”
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Effects of Endurance Exercise and Vitamin D Supplementation on Insulin Resistance and Plasma Lipidome in Middle-Aged Adults with Type 2 Diabetes by Sun, Xiaomin, Yan, Tao, Li, Zhongying, Zhou, Sirui, Peng, Wen, Cui, Wei, Xu, Jing, Cao, Zhen-Bo, Shi, Lin, Wang, Youfa

“…(1) Background: We investigated the effects of a 12-week exercise intervention with or without vitamin D supplementation on insulin resistance and the plasma…”
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Associations between iron status and insulin resistance in Chinese children and adolescents: findings from the China Health and Nutrition Survey by Wei, Junxiang, Luo, Xiaoqin, Zhou, Sirui, He, Xin, Zheng, Jinge, Sun, Xiaomin, Cui, Wei

“…Background and Objectives: Iron homeostasis abnormalities are associated with insulin resistance (IR), but studies on such associations in children and…”
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