Search Results - "Zhou, Qiong L."

Imbalance between Neutrophil Elastase and its Inhibitor α1-Antitrypsin in Obesity Alters Insulin Sensitivity, Inflammation, and Energy Expenditure by Mansuy-Aubert, Virginie, Zhou, Qiong L., Xie, Xiangyang, Gong, Zhenwei, Huang, Jun-Yuan, Khan, Abdul R., Aubert, Gregory, Candelaria, Karla, Thomas, Shantele, Shin, Dong-Ju, Booth, Sarah, Baig, Shahid M., Bilal, Ahmed, Hwang, Daehee, Zhang, Hui, Lovell-Badge, Robin, Smith, Steven R., Awan, Fazli R., Jiang, Zhen Y.

“…The molecular mechanisms involved in the development of obesity and related complications remain unclear. Here, we report that obese mice and human subjects…”
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Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice by Ushakumari, Chinchu Jagadan, Zhou, Qiong L, Wang, Yu-Hua, Na, Sijia, Rigor, Michael C, Zhou, Cindy Y, Kroll, Max K, Lin, Benjamin D, Jiang, Zhen Y

“…Neutrophil elastase (NE) plays a pivotal role in inflammation. However, the mechanism underlying NE-mediated inflammation in obesity remains unclear. Here, we…”
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Insulin Signaling through Akt/Protein Kinase B Analyzed by Small Interfering RNA-Mediated Gene Silencing by Jiang, Zhen Y., Zhou, Qiong L., Coleman, Kerri A., Chouinard, My, Boese, Queta, Czech, Michael P.

“…Glucose homeostasis is controlled by insulin in part through the translocation of intracellular glucose transporter 4 to the plasma membrane in muscle and fat…”
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C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane by Xie, Xiangyang, Gong, Zhenwei, Mansuy-Aubert, Virginie, Zhou, Qiong L., Tatulian, Suren A., Sehrt, Daniel, Gnad, Florian, Brill, Laurence M., Motamedchaboki, Khatereh, Chen, Yu, Czech, Michael P., Mann, Matthias, Krüger, Marcus, Jiang, Zhen Y.

“…The protein kinase Bβ (Akt2) pathway is known to mediate insulin-stimulated glucose transport through increasing glucose transporter GLUT4 translocation from…”
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Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c by Czech, Michael P, Bose, Avirup, Guilherme, Adilson, Robida, Stacey I, Nicoloro, Sarah M. C, Zhou, Qiong L, Jiang, Zhen Y, Pomerleau, Darcy P

“…Insulin stimulates glucose uptake in muscle and adipocytes by signalling the translocation of GLUT4 glucose transporters from intracellular membranes to the…”
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Isoform-specific Regulation of Akt Signaling by the Endosomal Protein WDFY2 by Walz, Helena A., Shi, Xiarong, Chouinard, My, Bue, Catherine A., Navaroli, Deanna M., Hayakawa, Akira, Zhou, Qiong L., Nadler, Jonathan, Leonard, Deborah M., Corvera, Silvia

“…Recent work has led to the identification of novel endocytic compartments with functional roles in both protein trafficking and growth factor signal…”
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Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes by Zhou, Qiong L, Jiang, Zhen Y, Holik, John, Chawla, Anil, Hagan, G Nana, Leszyk, John, Czech, Michael P

“…Multiple studies have suggested that the protein kinase Akt/PKB (protein kinase B) is required for insulin-stimulated glucose transport in skeletal muscle and…”
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Identification of WNK1 as a Substrate of Akt/Protein Kinase B and a Negative Regulator of Insulin-stimulated Mitogenesis in 3T3-L1 Cells by Jiang, Zhen Y., Zhou, Qiong L., Holik, John, Patel, Shraddha, Leszyk, John, Coleman, Kerri, Chouinard, My, Czech, Michael P.

“…Insulin signaling through protein kinase Akt/protein kinase B (PKB), a downstream element of the phosphatidylinositol 3-kinase (PI3K) pathway, regulates…”
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1853-P: Neutrophils Play a Pivotal Role in Obesogenic Diet-Induced Nonalcoholic Steatohepatitis by ZHOU, QIONG L., KHAN, SHOAIB, RIGOR, MICHAEL, BEERAM, INDEEVAR, JIANG, ZHEN Y.

“…Lipid deposition, inflammatory damage, and fibrotic remodel are the hallmarks of nonalcoholic steatohepatitis (NASH). However, the molecular and cellular…”
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Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release by Zhou, Qiong L., Song, Ye, Huang, Chun-Hong, Huang, Jun-Yuan, Gong, Zhenwei, Liao, Zhangping, Sharma, Andria G., Greene, Lily, Deng, Justin Z., Rigor, Michael C., Xie, Xiangyang, Qi, Songtao, Ayala, Julio E., Jiang, Zhen Y.

“…CDP138 is a calcium- and lipid-binding protein that is involved in membrane trafficking. Here, we report that mice without CDP138 develop obesity under normal…”
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A Novel Pleckstrin Homology Domain-containing Protein Enhances Insulin-stimulated Akt Phosphorylation and GLUT4 Translocation in Adipocytes by Zhou, Qiong L., Jiang, Zhen Y., Mabardy, Allan S., Del Campo, Claudia M., Lambright, David G., Holik, John, Fogarty, Kevin E., Straubhaar, Juerg, Nicoloro, Sarah, Chawla, Anil, Czech, Michael P.

“…Protein kinase B/Akt protein kinases control an array of diverse functions, including cell growth, survival, proliferation, and metabolism. We report here the…”
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Photoactivated 3-Azioctanol Irreversibly Desensitizes Muscle Nicotinic ACh Receptors via Interactions at αE262 by Forman, Stuart A, Zhou, Qiong L, Stewart, Deirdre S

“…3-Azioctanol is a photoactivatable analogue of octanol that noncompetitively inhibits nicotinic acetylcholine receptors (nAChRs). Photolabeling studies using…”
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The n-Alcohol Site in the Nicotinic Receptor Pore Is a Hydrophobic Patch by Zhou, Qiong L, Zhou, Qing, Forman, Stuart A

“…Alcohols and volatile anesthetics inhibit peripheral nicotinic acetylcholine receptors noncompetitively, primarily via an open-channel block mechanism…”
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Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262 by Forman, Stuart A, Zhou, Qiong L, Stewart, Deirdre S

“…3-Azioctanol is a photoactivatable analogue of octanol that noncompetitively inhibits nicotinic acetylcholine receptors (nAChRs). Photolabeling studies using…”
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SiRNA-Mediated Gene Silencing of Potential Akt Substrates Reveals That GTPase Activating Protein TBC1D1 Regulates Glucose Uptake and Adiponectin Secretion in 3T3-L1 Adipocytes by Jiang, Zhen Y, Zhou, Qiong L, Holik, John, Patel, Shraddha

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Room D, 10/17/2000 9: 00 AM - 11: 00 AM (PS) Mutation of an Anesthetic-Photolabeled Residue in the nAChR Pore Alters Sensitivity to GAs by Zhou, Qiong L., Forman, Stuart A.

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Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands by Shen, Jian, Yang, Xi-cheng, Yu, Ming-cheng, Xiao, Li, Zhang, Xun-jie, Sun, Hui-jiao, Chen, Hao, Pan, Guan-xin, Yan, Yu-rong, Wang, Si-chen, Li, Wei, Zhou, Lu, Xie, Qiong, Yu, Lin-qian, Wang, Yong-hui, Shao, Li-ming

“…The homomeric α7 nicotinic receptor （α7 nAChR） is widely expressed in the human brain that could be activated to suppress neuroinflammation, oxidative stress…”
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Hybrid hierarchy storage system in MilkyWay-2 supercomputer by XU, Weixia, LU, Yutong, LI, Qiong, ZHOU, Enqiang, SONG, Zhenlong, DONG, Yong, ZHANG, Wei, WEI, Dengping, ZHANG, Xiaoming, CHEN, Haitao, XING, Jianying, YUAN, Yuan

“…With the rapid improvement of computation capability in high performance supercomputer system, the imbalance of performance between computation subsystem and…”
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Degradation of Hydrogenated Nitrile-butadiene Rubber in Aqueous Solutions of HeS or HCI by CONG Chuan-bo CUI Can-can MENG Xiao-yu LU Shao-jie ZHOU Qiong

“…The degradation of hydrogenated nitrile-butadiene rubber（HNBR） soaped in aqueous solutions of HzS and HC1 was investigated, The samples unexposed and exposed…”
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Effect of ALA-PDT on the expressions ofMMP-9, MMP-13 TIMP-1 of hypertrophic scar model in rabbit ears by ZHOU Pengjun WANG Qiong LI Zhangjun XIAO Shengxiang XU Lujie LI Yinghui MA Yunyun

“…Objective： To investigate the effect of 5-aminolevulinic （ALA）-photodynamic therapy （PDT） on the expressions of MMP-9, MMP-13 and TIMP-1 of hypertrophic scar…”
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