Search Results - "Zhou, Jujun"

Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix by Zhou, Jujun, Horton, John R., Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong

“…Clostridioides difficile infections are an urgent medical problem. The newly discovered C. difficile a denine m ethyltransferase A (CamA) is specified by all…”
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Identification and characterization of MAVS from black carp Mylopharyngodon piceus by Zhou, Wei, Zhou, Jujun, Lv, Ying, Qu, Yixiao, Chi, Mengdie, Li, Jun, Feng, Hao

“…MAVS (mitochondria antiviral signaling protein) plays an important role in the host cellular innate immune response against microbial pathogens. In this study,…”
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Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA by Zhou, Jujun, Horton, John R., Yu, Dan, Ren, Ren, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong

“…Epigenetically targeted therapeutic development, particularly for SAM-dependent methylations of DNA, mRNA and histones has been proceeding rapidly for cancer…”
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SART3 reads methylarginine-marked glycine- and arginine-rich motifs by Wang, Yalong, Zhou, Jujun, He, Wei, Fu, Rongjie, Shi, Leilei, Dang, Ngoc Khoi, Liu, Bin, Xu, Han, Cheng, Xiaodong, Bedford, Mark T.

“…Glycine- and arginine-rich (GAR) motifs, commonly found in RNA-binding and -processing proteins, can be symmetrically (SDMA) or asymmetrically (ADMA)…”
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On-Demand Activation of a Bioorthogonal Prodrug of SN-38 with Fast Reaction Kinetics and High Releasing Efficiency In Vivo by Zhou, Zhou, Feng, Shun, Zhou, Jujun, Ji, Xingyue, Long, Ya-Qiu

“…Although a myriad of bioorthogonal prodrugs have been developed, very few of them present both fast reaction kinetics and complete cleavage. Herein, we report…”
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A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2 by Horton, John R., Zhou, Jujun, Chen, Qin, Zhang, Xing, Bedford, Mark T., Cheng, Xiaodong

“…The N-terminal half of PHF2 harbors both a plant homeodomain (PHD) and a Jumonji domain. The PHD recognizes both histone H3 trimethylated at lysine 4 and…”
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Enzymatic Characterization of In Vitro Activity of RNA Methyltransferase PCIF1 on DNA by Yu, Dan, Zhou, Jujun, Chen, Qin, Wu, Tao, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong

“…PCIF1 and FTO are a pair of human mRNA cap-specific modification enzymes that have opposing activities. PCIF1 adds a methyl group to the N6-position of…”
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Extraordinary structures of orphan methyltransferases with their substrate DNA by Horton, John, Zhou, Jujun, Woodcock, Clayton, Zhang, Xing, Cheng, Xiaodong

“…Abstract only…”
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Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the Bdelloid rotifer Adineta vaga by Zhou, Jujun, Horton, John R., Kaur, Gundeep, Chen, Qin, Li, Xuwen, Mendoza, Fabian, Wu, Tao, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong

“…Much is known about the generation, removal, and roles of 5-methylcytosine (5mC) in eukaryote DNA, and there is a growing body of evidence regarding…”
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Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA by Woodcock, Clayton B, Horton, John R, Zhou, Jujun, Bedford, Mark T, Blumenthal, Robert M, Zhang, Xing, Cheng, Xiaodong

“…The recently characterized mammalian writer (methyltransferase) and eraser (demethylase) of the DNA N6-methyladenine (N6mA) methyl mark act on single-stranded…”
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Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs by Yu, Dan, Dai, Nan, Wolf, Eric J., Corrêa, Ivan R., Zhou, Jujun, Wu, Tao, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong

“…The phosphorylated RNA polymerase II CTD interacting factor 1 (PCIF1) is a methyltransferase that adds a methyl group to the N6-position of 2′O-methyladenosine…”
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Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence by Zhou, Jujun, Horton, John R., Menna, Martina, Fiorentino, Francesco, Ren, Ren, Yu, Dan, Hajian, Taraneh, Vedadi, Masoud, Mazzoccanti, Giulia, Ciogli, Alessia, Weinhold, Elmar, Hüben, Michael, Blumenthal, Robert M., Zhang, Xing, Mai, Antonello, Rotili, Dante, Cheng, Xiaodong

“…Antivirulence agents targeting endospore-transmitted Clostridioides difficile infections are urgently needed. C. difficile-specific DNA adenine…”
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Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase by Zhou, Jujun, Deng, Youchao, Iyamu, Iredia D., Horton, John R., Yu, Dan, Hajian, Taraneh, Vedadi, Masoud, Rotili, Dante, Mai, Antonello, Blumenthal, Robert M., Zhang, Xing, Huang, Rong, Cheng, Xiaodong

“…S-Adenosyl-l-methionine (SAM) analogs are adaptable tools for studying and therapeutically inhibiting SAM-dependent methyltransferases (MTases). Some MTases…”
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The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA by Hardikar, Swanand, Ren, Ren, Ying, Zhengzhou, Zhou, Jujun, Horton, John R, Bramble, Matthew D, Liu, Bin, Lu, Yue, Liu, Bigang, Coletta, Luis Della, Shen, Jianjun, Dan, Jiameng, Zhang, Xing, Cheng, Xiaodong, Chen, Taiping

“…, encoding a protein with a carboxyl-terminal cysteine-rich domain (CRD), is mutated in immunodeficiency, centromeric instability, and facial anomalies (ICF)…”
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