Search Results - "Zhou, Huan"

Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation by Zhou, Huan-Xiang, Pang, Xiaodong

“…Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less specific electrostatic interactions, impart important properties to…”
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Protein Allostery and Conformational Dynamics by Guo, Jingjing, Zhou, Huan-Xiang

“…The functions of many proteins are regulated through allostery, whereby effector binding at a distal site changes the functional activity (e.g., substrate…”
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Determinants for Fusion Speed of Biomolecular Droplets by Ghosh, Archishman, Zhou, Huan‐Xiang

“…Biomolecular droplets formed through phase separation have a tendency to fuse. The speed with which fusion occurs is a direct indicator of condensate…”
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Three archetypical classes of macromolecular regulators of protein liquid–liquid phase separation by Ghosh, Archishman, Mazarakos, Konstantinos, Zhou, Huan-Xiang

“…Membraneless organelles, corresponding to the droplet phase upon liquid–liquid phase separation (LLPS) of protein or protein–RNA mixtures, mediate myriad…”
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Influence of crowded cellular environments on protein folding, binding, and oligomerization: Biological consequences and potentials of atomistic modeling by Zhou, Huan-Xiang

“…Recent experiments inside cells and in cytomimetic conditions have demonstrated that the crowded environments found therein can significantly reshape the…”
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Association of muscle wasting with mortality risk among adults: A systematic review and meta‐analysis of prospective studies by Zhou, Huan‐Huan, Liao, Yuxiao, Peng, Zhao, Liu, Fang, Wang, Qi, Yang, Wei

“…The relationship between muscle wasting and mortality risk in the general population remains unclear. Our study was conducted to examine and quantify the…”
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Determination of Condensate Material Properties from Droplet Deformation by Zhou, Huan-Xiang

“…I derive theoretical results that relate the effective spring constant, χ, of protein droplets to their material properties. χ, defined as the ratio between a…”
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Shear relaxation governs fusion dynamics of biomolecular condensates by Ghosh, Archishman, Kota, Divya, Zhou, Huan-Xiang

“…Phase-separated biomolecular condensates must respond agilely to biochemical and environmental cues in performing their wide-ranging cellular functions, but…”
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Partial mimicry of the microtubule binding of tau by its membrane binding by MacAinsh, Matthew, Zhou, Huan‐Xiang

“…Tau, as typical of intrinsically disordered proteins (IDPs), binds to multiple targets including microtubules and acidic membranes. The latter two surfaces are…”
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The effect of physical exercise on circulating brain‐derived neurotrophic factor in healthy subjects: A meta‐analysis of randomized controlled trials by Wang, Ya‐Hai, Zhou, Huan‐Huan, Luo, Qiang, Cui, Sidong

“…Objective To investigate how physical exercise (PE) would affect brain‐derived neurotrophic factor (BDNF) in randomized controlled trials (RCTs) of healthy…”
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Liquid-Liquid Phase Separation of Patchy Particles Illuminates Diverse Effects of Regulatory Components on Protein Droplet Formation by Nguemaha, Valery, Zhou, Huan-Xiang

“…Recently many cellular functions have been associated with membraneless organelles, or protein droplets, formed by liquid-liquid phase separation (LLPS)…”
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Shape recovery of deformed biomolecular droplets: Dependence on condensate viscoelasticity by Zhou, Huan-Xiang

“…A theoretical study on the shape dynamics of phase-separated biomolecular droplets is presented, highlighting the importance of condensate viscoelasticity…”
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Macromolecular regulators have matching effects on the phase equilibrium and interfacial tension of biomolecular condensates by Mazarakos, Konstantinos, Zhou, Huan‐Xiang

“…The interfacial tension of phase‐separated biomolecular condensates affects their fusion and multiphase organization, and yet how this important property…”
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Intrinsic disorder: signaling via highly specific but short-lived association by Zhou, Huan-Xiang

“…Association between signaling proteins and their cellular targets is generally thought to be highly specific (implicating a high association constant, Ka) and,…”
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Adenosine Triphosphate Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks by Kota, Divya, Prasad, Ramesh, Zhou, Huan-Xiang

“…Adenosine triphosphate (ATP) is an abundant molecule with crucial cellular roles as the energy currency and a building block of nucleic acids and for protein…”
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Why Do Disordered and Structured Proteins Behave Differently in Phase Separation? by Zhou, Huan-Xiang, Nguemaha, Valery, Mazarakos, Konstantinos, Qin, Sanbo

“…Intracellular membraneless organelles and their myriad cellular functions have garnered tremendous recent interest. It is becoming well accepted that they form…”
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From Induced Fit to Conformational Selection: A Continuum of Binding Mechanism Controlled by the Timescale of Conformational Transitions by Zhou, Huan-Xiang

“…In receptor-ligand binding, a question that generated considerable interest is whether the mechanism is induced fit or conformational selection. This question…”
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Influences of Membrane Mimetic Environments on Membrane Protein Structures by Zhou, Huan-Xiang, Cross, Timothy A

“…The number of membrane protein structures in the Protein Data Bank is becoming significant and growing. Here, the transmembrane domain structures of the…”
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Machine Learning-Enabled Pipeline for Large-Scale Virtual Drug Screening by Gupta, Aayush, Zhou, Huan-Xiang

“…Virtual screening is receiving renewed attention in drug discovery, but progress is hampered by challenges on two fronts: handling the ever-increasing sizes of…”
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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor by Lan, Jun, Ge, Jiwan, Yu, Jinfang, Shan, Sisi, Zhou, Huan, Fan, Shilong, Zhang, Qi, Shi, Xuanling, Wang, Qisheng, Zhang, Linqi, Wang, Xinquan

“…A new and highly pathogenic coronavirus (severe acute respiratory syndrome coronavirus-2, SARS-CoV-2) caused an outbreak in Wuhan city, Hubei province, China,…”
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