Search Results - "Zhou, Dezhong"

Complex polymer architectures through free-radical polymerization of multivinyl monomers by Gao, Yongsheng, Zhou, Dezhong, Lyu, Jing, A, Sigen, Xu, Qian, Newland, Ben, Matyjaszewski, Krzysztof, Tai, Hongyun, Wang, Wenxin

“…The construction of complex polymer architectures with well-defined topology, composition and functionality has been extensively explored as the molecular…”
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Highly branched  poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells by Liu, Shuai, Gao, Yongsheng, Zhou, Dezhong, Zeng, Ming, Alshehri, Fatma, Newland, Ben, Lyu, Jing, O’Keeffe-Ahern, Jonathan, Greiser, Udo, Guo, Tianying, Zhang, Fengzhi, Wang, Wenxin

“…Current therapies for most neurodegenerative disorders are only symptomatic in nature and do not change the course of the disease. Gene therapy plays an…”
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Controlled Polymerization of Multivinyl Monomers: Formation of Cyclized/Knotted Single‐Chain Polymer Architectures by Gao, Yongsheng, Newland, Ben, Zhou, Dezhong, Matyjaszewski, Krzysztof, Wang, Wenxin

“…Seventy years ago, Flory and Stockmayer predicted that the polymerization of multivinyl monomers (MVMs) would inevitably lead to insoluble cross‐linked gel…”
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Non-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system by O’Keeffe Ahern, Jonathan, Lara-Sáez, Irene, Zhou, Dezhong, Murillas, Rodolfo, Bonafont, Jose, Mencía, Ángeles, García, Marta, Manzanares, Darío, Lynch, Jennifer, Foley, Ruth, Xu, Qian, Sigen, A, Larcher, Fernando, Wang, Wenxin

“…Recent advances in molecular biology have led to the CRISPR revolution, but the lack of an efficient and safe delivery system into cells and tissues continues…”
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Engineering siRNA therapeutics: challenges and strategies by Ali Zaidi, Syed Saqib, Fatima, Faria, Ali Zaidi, Syed Aqib, Zhou, Dezhong, Deng, Wuquan, Liu, Shuai

“…Abstract Small interfering RNA (siRNA) is a potential method of gene silencing to target specific genes. Although the U.S. Food and Drug Administration (FDA)…”
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In-situ noncovalent interaction of ammonium ion enabled C–H bond functionalization of polyethylene glycols by Zhang, Zongnan, Lv, Xueli, Mu, Xin, Zhao, Mengyao, Wang, Sichang, Ke, Congyu, Ding, Shujiang, Zhou, Dezhong, Wang, Minyan, Zeng, Rong

“…The noncovalent interactions of ammonium ion with multidentate oxygen-based host has never been reported as a reacting center in catalytic reactions. In this…”
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A new developing class of gene delivery: messenger RNA-based therapeutics by Meng, Zhao, O'Keeffe-Ahern, Jonathan, Lyu, Jing, Pierucci, Luca, Zhou, Dezhong, Wang, Wenxin

“…Gene therapy has long been held as having the potential to become a front line treatment for various genetic disorders. However, the direct delivery of nucleic…”
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Construction of a novel macroporous imprinted biosensor based on quartz crystal microbalance for ribonuclease A detection by Liu, Shuai, Zhou, Dezhong, Guo, Tianying

“…A novel quartz crystal microbalance (QCM) biosensor with high selectivity and sensitivity has been developed for ribonuclease A determination. Macroporous…”
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A non-viral gene therapy for treatment of recessive dystrophic epidermolysis bullosa by Cutlar, Lara, Zhou, Dezhong, Hu, Xuejun, Duarte, Blanca, Greiser, Udo, Larcher, Fernando, Wang, Wenxin

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Intramolecular Cyclization Dominating Homopolymerization of Multivinyl Monomers toward Single-Chain Cyclized/Knotted Polymeric Nanoparticles by Gao, Yongsheng, Zhou, Dezhong, Zhao, Tianyu, Wei, Xuan, McMahon, Sean, O’Keeffe Ahern, Jonathan, Wang, Wei, Greiser, Udo, Rodriguez, Brian J., Wang, Wenxin

“…Polymerization of multifunctional monomers could produce polymers with different functionalities and novel macromolecular architectures. However, the ability…”
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Efficient gene transfection of suspension cells by highly branched poly(β-amino ester) by Che, Delu, Wang, Chenfei, Li, Zhili, Wang, Kaixuan, Sun, Shuaiwei, Zhang, Xinyue, Li, Yi, Chen, Zhengju, Guo, Lei, Hou, Yajing, Zhou, Dezhong, Geng, Songmei

“…Suspension cells play a crucial role in many biological processes. However, compared to adherent cells, it is particularly challenging to introduce exogenous…”
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A novel glutathione modified chitosan conjugate for efficient gene delivery by Li, Congxin, Guo, Tianying, Zhou, Dezhong, Hu, Yuling, Zhou, Hao, Wang, Shufang, Chen, Jiatong, Zhang, Zhengpu

“…A novel non-viral gene vector based on poly[poly(ethylene glycol) methacrylate] (PMPEG) and l-glutathione (GSH) grafted chitosan (CS) has been fabricated…”
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Highly Branched poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) for High Performance Gene Transfection by Zeng, Ming, Zhou, Dezhong, Ng, Singwei, Ahern, Jonathan O Keeffe, Alshehri, Fatma, Gao, Yongsheng, Pierucci, Luca, Greiser, Udo, Wang, Wenxin

“…The top-performing linear poly(β-amino ester) (LPAE), poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32), has demonstrated gene transfection…”
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Acrylate-Based PEG Hydrogels with Ultrafast Biodegradability for 3D Cell Culture by Li, Zhili, Zhou, Dezhong

“…Poly­(ethylene glycol) (PEG)-based hydrogels are particularly challenging to degrade, which hinders efficient cell harvesting within the gel matrix. Here,…”
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The target gene carrying validity to HePG2 cells with the brush-like glutathione modified chitosan compound by Li, Congxin, Zhou, Dezhong, Hu, Yuling, Zhou, Hao, Chen, Jiatong, Zhang, Zhengpu, Guo, Tianying

“…► Physiological stability of the glutathione and PEG modified chitosan as gene vector. ► Targeted characters to HepG2 cells probed by tracing cell uptake and…”
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miRNA delivery for skin wound healing by Meng, Zhao, Zhou, Dezhong, Gao, Yongsheng, Zeng, Ming, Wang, Wenxin

“…The wound healing has remained a worldwide challenge as one of significant public health problems. Pathological scars and chronic wounds caused by injury,…”
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Bioreducible Zinc(II)-Coordinative Polyethylenimine with Low Molecular Weight for Robust Gene Delivery of Primary and Stem Cells by Liu, Shuai, Zhou, Dezhong, Yang, Jixiang, Zhou, Hao, Chen, Jiatong, Guo, Tianying

“…To transform common low-molecular-weight (LMW) cationic polymers, such as poly­ethylen­imine (PEI), to highly efficient gene vectors would be of great…”
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Controllable C–H Alkylation of Polyethers via Iron Photocatalysis by Zhang, Zongnan, Li, Xinyang, Zhou, Dezhong, Ding, Shujiang, Wang, Minyan, Zeng, Rong

“…The efficient conversion of a C–H bond in the polyether chain to other functional groups provides great opportunities for development of novel applications in…”
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A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing by Xu, Qian, A, Sigen, Gao, Yongsheng, Guo, Linru, Creagh-Flynn, Jack, Zhou, Dezhong, Greiser, Udo, Dong, Yixiao, Wang, Fagang, Tai, Hongyun, Liu, Wenguang, Wang, Wei, Wang, Wenxin

“…[Display omitted] The injectable hydrogel with desirable biocompatibility and tunable properties can improve the efficacy of stem cell-based therapy. However,…”
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Tailoring Highly Branched Poly(β-amino ester)s for Efficient and Organ-Selective mRNA Delivery by Yong, Haiyang, Lin, Lixin, Li, Zhili, Guo, Rui, Wang, Chenfei, Liu, Shuai, Zhou, Dezhong

“…Development of mRNA therapeutics necessitates targeted delivery technology, while the clinically advanced lipid nanoparticles face difficulty for extrahepatic…”
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