Search Results - "Zhou, David W"

Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology by Tian, Fangyun, Lewis, Laura D., Zhou, David W., Balanza, Gustavo A., Paulk, Angelique C., Zelmann, Rina, Peled, Noam, Soper, Daniel, Santa Cruz Mercado, Laura A., Peterfreund, Robert A., Aglio, Linda S., Eskandar, Emad N., Cosgrove, G. Rees, Williams, Ziv M., Richardson, R. Mark, Brown, Emery N., Akeju, Oluwaseun, Cash, Sydney S., Purdon, Patrick L.

“…Ketamine produces antidepressant effects in patients with treatment-resistant depression, but its usefulness is limited by its psychotropic side effects…”
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Machine learning of EEG spectra classifies unconsciousness during GABAergic anesthesia by Abel, John H, Badgeley, Marcus A, Meschede-Krasa, Benyamin, Schamberg, Gabriel, Garwood, Indie C, Lecamwasam, Kimaya, Chakravarty, Sourish, Zhou, David W, Keating, Matthew, Purdon, Patrick L, Brown, Emery N

“…In current anesthesiology practice, anesthesiologists infer the state of unconsciousness without directly monitoring the brain. Drug- and patient-specific…”
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ICU delirium burden predicts functional neurologic outcomes by Paixao, Luis, Sun, Haoqi, Hogan, Jacob, Hartnack, Katie, Westmeijer, Mike, Neelagiri, Anudeepthi, Zhou, David W, McClain, Lauren M, Kimchi, Eyal Y, Purdon, Patrick L, Akeju, Oluwaseun, Westover, M Brandon

“…We investigated the effect of delirium burden in mechanically ventilated patients, beginning in the ICU and continuing throughout hospitalization, on…”
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Patient-Specific Classification of ICU Sedation Levels From Heart Rate Variability by Nagaraj, Sunil B., Biswal, Siddharth, Boyle, Emily J., Zhou, David W., McClain, Lauren M., Bajwa, Ednan K., Quraishi, Sadeq A., Akeju, Oluwaseun, Barbieri, Riccardo, Purdon, Patrick L., Westover, M. Brandon

“…OBJECTIVE:To develop a personalizable algorithm to discriminate between sedation levels in ICU patients based on heart rate variability. DESIGN:Multicenter,…”
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Automated tracking of level of consciousness and delirium in critical illness using deep learning by Sun, Haoqi, Kimchi, Eyal, Akeju, Oluwaseun, Nagaraj, Sunil B., McClain, Lauren M., Zhou, David W., Boyle, Emily, Zheng, Wei-Long, Ge, Wendong, Westover, M. Brandon

“…Over- and under-sedation are common in the ICU, and contribute to poor ICU outcomes including delirium. Behavioral assessments, such as Richmond…”
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Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder by Walsh, Elisa C, Lee, Johanna M, Terzakis, Kristina, Zhou, David W, Burns, Sara, Buie, Timothy M, Firth, Paul G, Shank, Erik S, Houle, Timothy T, Brown, Emery N, Purdon, Patrick L

“…Patients with autism spectrum disorder (ASD) often require sedation or general anesthesia. ASD is thought to arise from deficits in GABAergic signaling leading…”
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Percolation Model of Sensory Transmission and Loss of Consciousness Under General Anesthesia by Zhou, David W, Mowrey, David D, Tang, Pei, Xu, Yan

“…Neurons communicate with each other dynamically; how such communications lead to consciousness remains unclear. Here, we present a theoretical model to…”
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Propofol disrupts alpha dynamics in functionally distinct thalamocortical networks during loss of consciousness by Weiner, Veronica S, Zhou, David W, Kahali, Pegah, Stephen, Emily P, Peterfreund, Robert A, Aglio, Linda S, Szabo, Michele D, Eskandar, Emad N, Salazar-Gomez, Andrés F, Sampson, Aaron L, Cash, Sydney S, Brown, Emery N, Purdon, Patrick L

“…During propofol-induced general anesthesia, alpha rhythms measured using electroencephalography undergo a striking shift from posterior to anterior, termed…”
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Electrophysiological correlates of thalamocortical function in acute severe traumatic brain injury by Curley, William H., Bodien, Yelena G., Zhou, David W., Conte, Mary M., Foulkes, Andrea S., Giacino, Joseph T., Victor, Jonathan D., Schiff, Nicholas D., Edlow, Brian L.

“…Tools assaying the neural networks that modulate consciousness may facilitate tracking of recovery after acute severe brain injury. The ABCD framework…”
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Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit by Edlow, Brian L., Barra, Megan E., Zhou, David W., Foulkes, Andrea S., Snider, Samuel B., Threlkeld, Zachary D., Chakravarty, Sourish, Kirsch, John E., Chan, Suk-tak, Meisler, Steven L., Bleck, Thomas P., Fins, Joseph J., Giacino, Joseph T., Hochberg, Leigh R., Solt, Ken, Brown, Emery N., Bodien, Yelena G.

“…There are currently no therapies proven to promote early recovery of consciousness in patients with severe brain injuries in the intensive care unit (ICU). For…”
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Electroencephalogram Based Detection of Deep Sedation in ICU Patients Using Atomic Decomposition by Nagaraj, Sunil Belur, McClain, Lauren M., Boyle, Emily J., Zhou, David W., Ramaswamy, Sowmya M., Biswal, Siddharth, Akeju, Oluwaseun, Purdon, Patrick L., Westover, M. Brandon

“…Objective: This study was performed to evaluate how well states of deep sedation in 'CU patients can be detected from the frontal electroencephalogram (EEG)…”
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Automatic Classification of Sedation Levels in ICU Patients Using Heart Rate Variability by Nagaraj, Sunil B., McClain, Lauren M., Zhou, David W., Biswal, Siddharth, Rosenthal, Eric S., Purdon, Patrick L., Westover, M. Brandon

“…OBJECTIVE:To explore the potential value of heart rate variability features for automated monitoring of sedation levels in mechanically ventilated ICU…”
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Heart rate variability as a biomarker for sedation depth estimation in ICU patients by Nagaraj, Sunil B., Ramaswamy, Sowmya M., Biswal, Siddharth, Boyle, Emily J., Zhou, David W., Mcclain, Lauren M., Rosenthal, Eric S., Purdon, Patrick L., Westover, M. Brandon

“…An automated patient-specific system to classify the level of sedation in ICU patients using heart rate variability signal is presented in this paper. ECG from…”
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Structures and mechanism for the design of highly potent glucocorticoids by He, Yuanzheng, Yi, Wei, Suino-Powell, Kelly, Zhou, X Edward, Tolbert, W David, Tang, Xiaobo, Yang, Jing, Yang, Huaiyu, Shi, Jingjing, Hou, Li, Jiang, Hualiang, Melcher, Karsten, Xu, H Eric

“…The evolution of glucocorticoid drugs was driven by the demand of lowering the unwanted side effects, while keep ing the beneficial antiinflammatory effects…”
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Clustering analysis to identify distinct spectral components of encephalogram burst suppression in critically ill patients by Zhou, David W., Westover, M. Brandon, McClain, Lauren M., Nagaraj, Sunil B., Bajwa, Ednan K., Quraishi, Sadeq A., Akeju, Oluwaseun, Cobb, J. Perren, Purdon, Patrick L.

“…Millions of patients are admitted each year to intensive care units (ICUs) in the United States. A significant fraction of ICU survivors develop life-long…”
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The electroencephalogram: a missing piece in personalized anesthesia care by Purdon, Patrick L., Zhou, David W., Akeju, Oluwaseun, Brown, Emery N.

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